2,5-Dimethoxy-2,5-dihydrofuran 2,5-二甲氧基-2,5-二氢呋喃

CAS 332-77-4 MFCD00003220

化学结构图

332-77-4
SMILES: COC1C=CC(OC)O1

化学属性

Mol. FormulaC6H10O3
Mol. Weight130.14
Refractive index1.4320 to 1.4360
Boiling Point158-160°C at 760 mmHg
Density1.073
Flash Point47°C(lit.)
TSCAYes
Melting Point<-40 °C

别名和识别编码

Chemical Name2,5-Dihydro-2,5-dimethoxyfuran
Synonym 2,5-Dimethoxy-2,5-dihydrofuran {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,5-Dimethoxy-2,5-dihydrofuran {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00003220
CAS Number332-77-4
PubChem Substance ID78974
EC Number206-367-5
Beilstein Registry Number113225
Reaxys-RN113225
Chemical Name Translation2,5-二甲氧基-2,5-二氢呋喃
InChIKeyWXFWXFIWDGJRSC-UHFFFAOYSA-N
LabNetwork Molecule IDLN00222547
InChIInChI=1S/C6H10O3/c1-7-5-3-4-6(8-2)9-5/h3-6H,1-2H3
Canonical SMILESCOC1C=CC(OC)O1
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分类

  • {uni_hamburg} no charge; oxygen heterocycle; alicycle; 5ring; 1fragment
  • {SNA} Building Blocks, C4 to C7, Chemical Synthesis, Furans, Heterocyclic Building Blocks

产品应用

  • 重要医药中间体，可以合成消化系统药物阿托品硫酸盐、氢溴酸山莨菪碱等药物；经过盐酸水解、加氢可以制备重要精细石油化工中间体丁二醛。另外还可以催化加氢得到2，5-二甲氧基四氢呋喃。

相关文献及参考

  • Synthetic equivalent (cyclic acetal) of the unstable maleic dialdehyde.
  • Beilstein:17(5)5,73
  • Short: EINECS
  • Short: III/35E

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Signal word
UN Number UN3271
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P301+P317
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P317
  • P330 Rinse mouth. 漱口
  • P337+P317
  • P370+P378
  • P403+P235
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Risk Statements
  • R10 Flammable 易燃
Safety Statements
Packing GroupIII
Hazard Class3
Hazard Codes
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • Sigma Aldrich:332-77-4(sigmaaldrich)
  • 方法一:由呋喃经醚化、还原而得。反应在电解槽中进行。将甲醇和溴化铵加入电解槽内搅拌，至溴化铵溶解。将溶液降温至0℃时，加入呋喃，将电解槽密闭继续冷却至-5℃以下，开通电解电路输入电流，操作正常后逐渐将电压调至15V左右，电流至40-45A，电解温度控制在0-5℃。电解结束后，停止搅拌，将电解液吸至甲醇回收锅，进行碱化。然后加热驱除氨气，蒸出甲醇，至气相温度达65℃时甲醇回收完毕。冷却，过滤，滤液进行分馏，收集152-164℃的正沸点馏分，即得2,5-二甲氧基二氢呋喃。
  • TCI Shanghai:2,5-二甲氧基-2,5-二氢呋喃(顺反异构体混合物) 2,5-Dimethoxy-2,5-dihydrofuran (cis- and trans- mixture),>;98.0%(GC)(332-77-4)
  • 图谱信息:2,5-二甲氧基-2,5-二氢呋喃(332-77-4)质谱(MS) 2,5-二甲氧基-2,5-二氢呋喃(332-77-4)红外图谱(IR1) 2,5-二甲氧基-2,5-二氢呋喃(332-77-4)核磁图( 13 CNMR)
  • 2,5-二甲氧基-2,5-二氢呋喃价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 D1759 2,5-二甲氧基-2,5-二氢呋喃(顺反异构体混和物) 2,5-Dimethoxy-2,5-dihydrofuran (cis- and trans- mixture) 500G 3400元 2011/04/16 D1759 2,5-二甲氧基-2,5-二氢呋喃(顺反异构体混和物) 2,5-Dimethoxy-2,5-dihydrofuran (cis- and trans- mixture) 25G 400元 2010/05/25 B25028 2,5-二氢-2,5-二甲氧基呋喃, cis + trans, 99% 2,5-Dihydro-2,5-dimethoxyfuran, cis + trans, 99% 1kg 4480元
  • MSDS 信息:2,5-Dihydro-2,5-dimethoxyfuran(332-77-4).msds
  • 下游产品:2,5-二甲氧基四氢呋喃 --> 6-乙酰氧基托品酮 --> 丁二醛 --> 6-乙酰氧基托品 --> 哒嗪
  • 海关编码:29321900
  • Alfa Aesar:2,5-二氢-2,5-二甲氧基呋喃,cis+trans,99% 2,5-Dihydro-2,5-dimethoxyfuran, cis + trans, 99%(332-77-4)
  • 上游原料:4-氯苯甲醛 --> 溴化铵
  • 用途一:该品是合成法生产阿托品硫酸盐、山莨菪碱氢溴酸盐的中间体。2,5-二甲氧基二氢呋喃用盐酸水解生成2-羟基-1,4-丁二醛；加氢再水解可得丁二醛。
  • 2,5-二甲氧基-2,5-二氢呋喃价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1759 2,5-二甲氧基-2,5-二氢呋喃(顺反异构体混和物) 2,5-Dimethoxy-2,5-dihydrofuran (cis- and trans- mixture) 25G 331元 2011/04/16 D1759 2,5-二甲氧基-2,5-二氢呋喃(顺反异构体混和物) 2,5-Dimethoxy-2,5-dihydrofuran (cis- and trans- mixture) 500G 3400元 2010/05/25 B25028 2,5-二氢-2,5-二甲氧基呋喃, cis + trans, 99% 2,5-Dihydro-2,5-dimethoxyfuran, cis + trans, 99% 1kg 4480元
  • MOL 文件:332-77-4.mol

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Furans 呋喃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Furans 呋喃
  5. C4 to C7 - Furans