Furan 呋喃

CAS 110-00-9 MFCD00003222

化学结构图

110-00-9
SMILES: c1ccoc1

化学属性

Mol. FormulaC4H4O
Mol. Weight68
Refractive index1.4190 to 1.4240
Boiling Point31°C
Density0.94
Flash Point-35°C(lit.)
TSCAYes
Melting Point-85.6°C
Vapor Density2.35 (vs air)
Vapor Pressure1672 mmHg ( 55 °C)
Solubility不溶于水，溶于丙酮、苯，易溶于乙醇、乙醚等多数有机溶剂。

别名和识别编码

Chemical NameFuran
MDL NumberMFCD00003222
CAS Number110-00-9
Synonym tetrole Oxole Furan (phase II) NCI-C56202 一氧二烯五环,氧杂茂 oxacyclopentadiene Divinylene oxide Furfuran Tetrole 氧化环戊二烯 呋喃 Oxacyclopentadiene furan 1,4-Epoxy-1,3-butadiene oxole C4H4O (furan) Furane 二亚乙烯基氧化物 Axole RCRA waste number U124
PubChem Substance ID8029
EC Number203-727-3
Beilstein Registry Number17(5)1,291
Reaxys-RN103221
Merck Number4296
Chemical Name Translation呋喃
Wiswesser Line NotationT5OJ
LabNetwork Molecule IDLN00195280
InChIInChI=1S/C4H4O/c1-2-4-5-3-1/h1-4H
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {uni_hamburg} no charge; oxygen heterocycle; aromatic; 5ring; ether; 1fragment
  • {SNA} Building Blocks, C4 to C7, Chemical Synthesis, Furans, Heterocyclic Building Blocks

产品应用

  • 用作有机合成原料和溶剂。

相关文献及参考

  • Short: II/19b
  • Lithiation occurs at the 2-position. For the formation of furfuryl propargyl ethers and their subsequent base catalyzed intramolecular Diels-Alder cyclization to isobenzofuran derivatives, see: J. Org. Chem., 60, 6168 (1995). 2,5-Dilithiation can be effected with n-BuLi - TMEDA: J. Chem. Soc., Perkin 1, 887 (1977), or n-BuLi - KO-t-Bu: Synthesis, 316 (1988). A Barbier-type reaction has been reported in which furan is reacted with a lithium carboxylate in the presence of Li metal and t-butyl chloride with sonication: J. Org. Chem., 60, 8 (1995), providing an easy access to 2-furyl ketones.
  • Short: II/14a
  • Merck:14,4296 Beilstein:17(5)1,291
  • Diels-Alder cycloadditions of furans with reactive dienophiles, followed by dehydration of the resulting 7-oxabicyclo[2.2.1]heptenes generate benzenes, often with unusual substitution patterns; review: Heterocycles, 22, 875 (1984). Adducts of furans with alkynes can be deoxygenated to give aromatics, by reduction with a low-valent Ti reagent: Synthesis, 787 (1984).
  • Short: II/24B
  • Merck:14,4296

安全信息

GHS Symbol
WGK Germany3
Hazard Codes F+,T F+;T
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H331 Toxic if inhaled 吸入中毒
  • H302 Harmful if swallowed 吞食有害
  • H350 May cause cancer 可能致癌
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H224 Extremely flammable liquid and vapour 极端易燃液体和蒸气
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P308+P313
  • P332+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P403+P233
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P303+P361+P353
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
Signal word Danger {} {} {} {} {} {} {} {} {} {} {TCI}
RTECSLT8524000
UN Number 2389 UN2389
Risk Statements
  • R12 Extremely flammable 极端易燃
  • R48/22
  • R19 May form explosive peroxides 可能生成易爆的过氧化物质
  • R45 May cause cancer 可能致癌
  • R52/53
  • R38 Irritating to skin 刺激皮肤
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Storage condition Air & Light Sensitive 密封2-8°C保存
Packing GroupI
Hazard Class3
Warnings 危化品目录(2015) 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4160 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-402,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1040 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Liver - angiosarcoma
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-402,1993

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 234 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - nausea or vomiting
   Blood - hemorrhage
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 26,281,1926

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/m3/1H
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   40,310,1979

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Blood - hemorrhage
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 26

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 184 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   13,89,1981

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 3500 ug/disc
REFERENCE :
   DFSCDX Developments in Food Science.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1978- Volume(issue)/page/year:
   13,353,1986

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1139 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12,85,1988

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 825 nmol/plate
REFERENCE :
   DFSCDX Developments in Food Science.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1978- Volume(issue)/page/year:
   13,353,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3900 mg/kg
SEX/DURATION            : male 13 week(s) pre-mating
                          female 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-402,1993

Restrict 危险品

其他信息

  • 久贮或见光易变棕色,易变质。对碱液稳定，遇矿酸或加热蒸发能树脂化。极易溶于乙醇和乙醚，不溶于水。易燃。半数致死量(大鼠，腹腔)5200mg/kg。其蒸气有麻醉性。能从皮肤吸收。有致癌可能性。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Coumarins 香豆素
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Furans 呋喃
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. F - Alphabetic
  5. FM - FZ - F
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Furans 呋喃
  5. C4 to C7 - Furans