Hyodeoxycholic acid 猪去氧胆酸

CAS 83-49-8 MFCD00003681

化学结构图

83-49-8
SMILES: CC(CCC(=O)O)C1CCC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C

化学属性

Mol. FormulaC24 H40 O4
Mol. Weight392.57
Melting Point200-201
TSCANo
Density1.128
Appearance 本品能抑制胆酸的形成及溶解脂肪，降低血中胆固醇和甘油三酯。 本品是由猪胆汁中提取的一种胆烷酸，为白色或略带微黄色粉末，臭且微腥、味苦。Mp 197℃(分解)。略溶于醇，在丙酮中微溶，在乙醚、氯仿中极微溶，几乎不溶于水。

别名和识别编码

Chemical NameHyodeoxycholic acid
CAS Number83-49-8
Synonym 3alpha,6alpha-Dihydroxy-5beta-cholan-24-oic acid 3α,6α-Dihydroxy-5β-cholan-24-oic acid 5-BETA-CHOLANIC ACID-3-ALPHA, 6-ALPHA-DIOL 5BETA-CHOLAN-24 OIC ACID-3ALPHA,6ALPHA-DIOL 6-alpha-hydroxylithocholicacid 7-Deoxyhyocholic acid 7-deoxyhyocholicacid Alpha-Hyodeoxycholic Acid Hyodeoxycholic acid a-Hyodeoxycholic Acid alpha-Hyodeoxycholic Acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00003681
PubChem Substance ID5283820
EC Number201-483-2
Merck Number14,4857
Chemical Name Translation猪去氧胆酸
Beilstein Registry Number3218394
LabNetwork Molecule IDLN01285032
InChIInChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
Canonical SMILESC[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} Bile acids and Derivatives, Biochemicals and Reagents, Lipids, Sterol Lipids
  • Steroids
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • {SNA} Bile acids and Derivatives, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, H, Sterol Lipids, 生物活性小分子, 细胞生物学, 脂类
  • {Chemicalbook} 生物化学品: 脂类: 固醇及类固醇类
  • {SNA} Bile acids and Derivatives, Bioactive Small Molecule Alphabetical Index, H, Sterol Lipids, 生化试剂, 生物活性小分子, 细胞生物学, 脂类

产品应用

  • 降血脂、降低血中胆固醇、降低转氨酶等。

相关文献及参考

  • [2]. Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27(9):3805-17.
  • Abadie, C., et al.: Biochem. J., 299, 725
  • Merck: 14,4857
  • Merck: 14,4857 Beilstein: 10,III,1631
  • [1]. Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41.
  • [1]. Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J Med Chem. 2008 Mar 27;51(6):1831-41.
  • [2]. Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB J. 2013 Sep;27(9):3805-17.

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSFZ2050000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition +4°C 2-8°C, protect from light 4℃ {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {ALD} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Signal word Warning
GHS Symbol 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 5600 umol/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   60,192,1987

Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激

其他信息

  • 用途三:用于降低血中胆固醇。
  • 图谱信息:猪去氧胆酸(83-49-8)核磁图( 13 CNMR) 猪去氧胆酸(83-49-8)红外图谱(IR1) 猪去氧胆酸(83-49-8)质谱(MS) 猪去氧胆酸(83-49-8)红外图谱(IR2)
  • Sigma Aldrich:83-49-8(sigmaaldrich)
  • Alfa Aesar:二羟基胆烷酸,98% Hyodeoxycholic acid, 98%(83-49-8)
  • 用途二:适用于Ia和Ib型高血脂症、动脉粥样硬化症。对百日咳杆菌、白喉杆菌、金黄色葡萄球菌等有一定的抑菌作用。也适用于胆道炎，胆囊炎、胆石症和其他非阻塞性胆汁郁积，可加速胆囊造影剂排出肝脏以有助于显影。能促进肠道脂肪分解和脂溶性维生素的吸收，可用于肝胆疾患引起的消化不良。可用作消炎药，治疗慢性支气管炎、小儿病毒性呼吸道炎症。偶可引起肠胃不适，轻度腹泻等。
  • 用途四:降血脂、降低血中胆固醇、降低转氨酶等。
  • 猪去氧胆酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 B20506 二羟基胆烷酸, 98% Hyodeoxycholic acid, 98% 5g 497元 2010/05/25 B20506 二羟基胆烷酸, 98% Hyodeoxycholic acid, 98% 25g 1596元 2010/05/25 B20506 二羟基胆烷酸, 98% Hyodeoxycholic acid, 98% 100g 5656元
  • MOL 文件:83-49-8.mol
  • TCI Shanghai:猪去氧胆酸 Hyodeoxycholic Acid,>;98.0%(T)(83-49-8)
  • MSDS 信息:Hyodeoxycholic acid(83-49-8).msds
  • 方法一:以新鲜猪胆汁为原料 猪胆汁酸的制备 取新鲜猪胆汁，加饱和石灰水上清液加热至沸制备胆红素钙盐，母液趁热加盐酸酸化至刚果红变蓝，析出结合猪胆汁酸的黑色胶状沉淀，除去乳状液，收集沉淀物，加自来水冲洗后变硬变脆，得猪胆汁酸。 猪胆汁[饱和石灰水]→[pH11-12, 100℃]母液[HCl]→沉淀物[水]→猪胆汁酸 粗品的制备 取粗制猪胆汁酸，加1.5倍质量的氢氧化钠，加9倍量体积的水，加热16h以上，冷却，静置分层，倾出上层淡黄色液体，沉淀物加少量水溶解，加稀盐酸或硫酸(2：1)酸化至刚果红试纸变蓝，取出析出物，过滤，水洗至中性，呈金黄色，真空干燥，得粗品。 猪胆汁酸[NaOH, 水]→[>;16h]皂化液[HCl]→粗品 异去氧胆酸成品的制备 取粗品，加5倍量乙酸乙酯，加150-200g/L活性炭，加热搅拌回流溶解，放冷，过滤，滤渣加3倍量乙酸乙酯回流，过滤，合并两次滤液，加200g/L无水硫酸钠，过滤，得滤液。浓缩至原体积的1/5-1/3，放冷，析出晶体，抽滤，得结晶，用乙酸乙酯洗涤，真空干燥，得异去氧胆酸成品。 粗品[乙酸乙酯，活性炭]→滤液[无水Na2SO4]→滤液→结晶[乙酸乙酯]→异去氧胆酸成品。
  • 用途一:能降低血中胆固醇，治疗和预防冠心病、高血压等
  • 上游原料:乙酸乙酯 --> 硫酸钠 --> 刚果红试纸 --> 碱性橙 2 --> 胆红素 --> 直接红 28 --> 胆酸钠

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Sterol Lipids - Lipids
  5. Bile acids and Derivatives - Sterol Lipids
  1. Life Science 生命科学
  2. Biochemistry / Glyco-Chemistry
  3. Steroids
  1. Medical Research Areas
  2. GPCR & G Protein
  3. GPCR19  (G蛋白偶联受体19)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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