4-Aminomorpholine 4-氨基吗啉

CAS 4319-49-7 MFCD00006174

化学结构图

4319-49-7
SMILES: NN1CCOCC1

化学属性

Mol. FormulaC4H10N2O
Mol. Weight102.14
Density1.059
Refractive index1.4750 to 1.4800
Boiling Point168°C at 760 mmHg
Flash Point58°C
TSCANo
SolubilityMISCIBLE
Appearance 无色透明。沸点168℃，相对密度1.059，折光率1.4772，闪点58℃。

别名和识别编码

Chemical Name4-Aminomorpholine
Synonym N-Aminomorpholine {LY} N-Aminomorpholine {} {LY} N-Aminomorpholine {} {} {LY} N-Aminomorpholine {} {} {} {LY} N-Aminomorpholine {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Aminomorpholine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N-Ami
CAS Number4319-49-7
EC Number224-347-4
Beilstein Registry Number27,8
MDL NumberMFCD00006174
PubChem Substance ID20315
Alfabeta NameAMINOMORPHOLINE 4-
Reaxys-RN103145
Chemical Name Translation4-氨基吗啉
Wiswesser Line NotationT6N DOTJ AZ
InChIKeyMKQLBNJQQZRQJU-UHFFFAOYSA-N
LabNetwork Molecule IDLN00180067
InChIInChI=1S/C4H10N2O/c5-6-1-3-7-4-2-6/h1-5H2
Canonical SMILESNN1CCOCC1
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {uni_hamburg} no charge; oxygen heterocycle; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; ether; 1fragment
  • {SNA} Building Blocks, C4 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Morpholines/Thiomorpholines

相关文献及参考

  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: III/20a Title: Nuclear Quadrupole Resonance Spectroscopy Data: Nuclei D ... Cl Author: Chihara, H.; Nakamura, N. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: III/20a Year: 1988 Keyword: NQR ISBN: 3-540-18161-X ISBN: 978-3-540-18161-3 Internet Resource: DOI:10.1007/b31153 RefComment: IX,677 pages. Hardcover Abstract: Nuclear Quadrupole Resonance Spectroscopy has become a standard method for structural research in molecular and solid state physics as well as for different branches of chemistry. The volumes cover data for more than 8,000 substances in the solid state. Data for free molecules have been published in volumes II/14 and II/15 of the New Series. The tables are arranged according to the atomic number of the elements.

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P330+P331
  • P301+P330+P331+P310
  • P302+P352
  • P303+P361+P353
  • P304+P312
  • P304+P340
  • P305+P351+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSQD7300000
Packing GroupIII
UN Number 1993 2733
Hazard Codes 3 Xn,F,Xi
Warnings IRRITANT
Hazard Class3/8 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella
   Postale 227, 27100 Pavia, Italy)  V.44-   1989-  Volume(issue)/page/year:
   45,223,1990

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 3 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 91,199,1981

Storage condition -20°C, protect from light {LY} -20°C, protect from light {} {LY} -20°C, protect from light {} {} {LY} -20°C, protect from light {} {} {} {LY} -20°C, protect from light {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

  • Alfa Aesar:4-氨基吗啉,98% 4-Aminomorpholine, 98%(4319-49-7)
  • Sigma Aldrich:4319-49-7(sigmaaldrich)
  • 图谱信息:N-氨基吗啉(4319-49-7)红外图谱(IR1) N-氨基吗啉(4319-49-7)质谱(MS)
  • TCI Shanghai:N-氨基吗啉 4-Aminomorpholine,>;98.0%(GC)(T)(4319-49-7)
  • MSDS 信息:4-Aminomorpholine(4319-49-7).msds
  • 上游原料:二氯乙醚
  • N-氨基吗啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0832 4-氨基吗啉 4-Aminomorpholine 5ML 280元 2014/06/02 A0832 4-氨基吗啉 4-Aminomorpholine 25ML 878元 2010/06/21 104110250 N-氨基吗啉 N-Aminomorpholine 97% 25 GR 2042元
  • 下游产品:吗多明 --> (4-吗啉基亚硝基氨基)乙腈 --> 5-氨基-3-(4-吗啉基)-1,2,3-恶二唑盐酸盐
  • 方法一:由二氯二乙醚与水合肼环合而得。将二氯二乙醚，水合肼及乙醇加入反应罐，搅拌下缓慢升温，回流2h。在保持回流的同时，4h内分批加入氢氧化钠。然后冷却至10℃过滤，弃去滤渣。滤液在常压下回收乙醇至回收量为投料的量的90%。反应液冷却至40-50℃，再加氢氧化钠。搅拌至氢氧化钠溶解后继续搅拌30min。冷却至10-15℃，甩滤，滤渣弃去。滤液用甲苯提取2次（第二次提取液在下批反应中套用）。减压回收甲苯后，收集70-80℃（6.67kPa）馏分。含量20%以上为正沸物，即4-氨基吗啉。
  • MOL 文件:4319-49-7.mol
  • Acros Organics:N-氨基吗啉 N-Aminomorpholine, 97%(4319-49-7)
  • Hazard Note:Harmful
  • 海关编码:29349990
  • 用途一:医药中间体。用于生产吗导敏。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoxazoles 异恶唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Morpholines/Thiomorpholines 吗啉/硫吗啉
  5. C4 to C10 - Morpholines/Thiomorpholines