Bicine N-二（2-羟乙基）甘氨酸

CAS 150-25-4 MFCD00004295

化学结构图

150-25-4
SMILES: O=C(O)CN(CCO)CCO

化学属性

Mol. FormulaC6H13NO4
Mol. Weight163.17
Density1.06 g/mL at 20 °C
Melting Point190 °C
SolubilitySoluble in water (1M) at 20 °C, ethanol (slightly), ether (slightly), and chloroform (slightly).
TSCAYes
Stability易吸湿
Boiling Point290.25 °C at 760 mmHg

别名和识别编码

Chemical NameBicine
Synonym Bicine {LY} Bicine {} {LY} Bicine {} {} {LY} Bicine {} {} {} {LY} Bicine {} {} {} {} {LY} Bicine {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bicine {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00004295
PubChem Substance ID8761
Beilstein Registry Number1769362
CAS Number150-25-4
EC Number205-755-1
Reaxys-RN1769362
Merck Number1201
Chemical Name TranslationN-二（2-羟乙基）甘氨酸
Wiswesser Line NotationQV1N2Q2Q
LabNetwork Molecule IDLN00192333
InChIInChI=1S/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)
Canonical SMILESO=C(O)CN(CCO)CCO
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分类

  • {SNA} Alphabetical, BioUltra Buffers, Zwitterionic, 生化试剂, 生物缓冲液
  • {SNA} BioXtra Buffers, Buffers / Buffers Salts, Buffers A to Z, Core Bioreagents, Good’s Buffers, Life Science Reagents for Western Blotting, Research Essentials, 生化试剂, 生物缓冲液
  • {SNA} BioXtra Buffers, Biological Buffers, Buffers / Buffers Salts, Buffers A to Z, Core Bioreagents, Good’s Buffers, Life Science Reagents for Western Blotting, Research Essentials
  • {SNA} Buffers A to Z,
  • {SNA} Crystallization and Renaturation Screening Kit Components, Peptide Analysis and Characterization, Peptides, 生

产品应用

  • 生物缓冲剂低温生化工作中推荐buffer。用在制备稳定的底物溶液，用于血清鸟嘌呤酶测定。也是用途非常广泛的一种Buffer,用于酶反应缓冲液，电泳缓冲液，工作浓度从3-100mM。

相关文献及参考

  • 2. S. Ito Clin. Chim. Acta 115 , 135, (1981)
  • Merck:14,1201 Beilstein: 4,IV,2390
  • Merck:14,1201
  • Biological buffer, pK a = 8.35 at 20 o : Biochemistry, 5, 467 (1966).

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSMB9700000
Signal word Warning
GHS Symbol
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1540 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   REPMBN Revue d'Epidemiologie, Medecine Sociale et Sante Publique.  (Masson
   Editeur, 120 Blvd. Saint-Germain, F-75280 Paris Cedex O6, France)  V.1-
   1953-  Volume(issue)/page/year: 10,391,1962

Hazard statements

其他信息

  • N,N-二羟乙基甘氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw020011 N,N-二羟乙基甘氨酸（BICINE） 100g 150元 2011/04/16 B0484 N,N-二(2-羟乙基)甘氨酸[生物研究用Good's缓冲液中的成分] N,N-Di(2-hydroxyethyl)glycine [Good's buffer component for biological research] 25G 262元 2011/04/16 B0484 N,N-二(2-羟乙基)甘氨酸[生物研究用Good's缓冲液中的成分] N,N-Di(2-hydroxyethyl)glycine [Good's buffer component for biological research] 500G 1970元
  • 图谱信息:N,N-二羟乙基甘氨酸(150-25-4)红外图谱(IR2) N,N-二羟乙基甘氨酸(150-25-4)质谱(MS) N,N-二羟乙基甘氨酸(150-25-4)Raman光谱 N,N-二羟乙基甘氨酸(150-25-4)红外图谱(IR1)
  • 用途二:生物缓冲剂低温生化工作中推荐buffer。用在制备稳定的底物溶液，用于血清鸟嘌呤酶测定。也是用途非常广泛的一种Buffer,用于酶反应缓冲液，电泳缓冲液，工作浓度从3-100mM。
  • MSDS 信息:N,N-Bis(2-hydroxyethyl)glycine(150-25-4).msds
  • 外观性质:白色晶体粉末。熔点: 190-192℃ pH range 7.6 - 9.0 pKa (25 °C) 8.3
  • 用途一:在生化研究中用作缓冲剂
  • MOL 文件:150-25-4.mol
  • F:3-10
  • Bicine is a zwitterionic amino acid buffer, active in the pH 7.6-9.0 range (pKa of 8.26 at 25°C). Recommended buffer for low temperature biochemical work. Bicine is used for the preparation of stable substrate solution for serum guanase determination. The use of bicine in a thin layer ion exchange chromatography method for protein resolution has been published. Bicine has been utilized in peptide and protein crystallization. A kinetic study of a quaternary transition-state analogue complex of creatine kinase used bicine in the reaction buffer. A multiphasic buffer system for SDS-PAGE of proteins and peptides that incorporates bicine has been described.
  • Acros Organics:N-二（2-羟乙基）甘氨酸 Bicine, for analysis, 99+%(150-25-4)
  • Sigma Aldrich:150-25-4(sigmaaldrich)
  • TCI Shanghai:N,N-二-(2-羟乙基)甘氨酸[生物研究用Good's缓冲液中的成分] N,N-Di(2-hydroxyethyl)glycine [Good's buffer component for biological research],>;98.0%(T)(150-25-4)
  • Alfa Aesar:N,N-二(2-羟乙基)甘氨酸,99% BICINE, 99%(150-25-4)
  • 海关编码:29225000

系列性分类

  1. Life Science 生命科学
  2. Biological Buffers 生理缓冲剂
  3. Buffers A to Z - Biological Buffers
  1. Life Science 生命科学
  2. Biological Buffers 生理缓冲剂
  3. BioUltra Buffers - Biological Buffers
  1. Life Science 生命科学
  2. Biological Buffers 生理缓冲剂
  3. BioUltra Buffers - Biological Buffers
  4. Alphabetical - BioUltra Buffers
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Peptides - Biochemicals and Reagents
  4. Peptide Analysis and Characterization - Peptides
  5. Crystallization and Renaturation Screening Kit Components - Peptide Analysis and Characterization
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C6 - Carboxylic Acids
  1. Life Science 生命科学
  2. Proteomics 蛋白质组学
  3. Protein Structural Analysis - Proteomics
  4. X-Ray Crystallography - Protein Structural Analysis
  5. Optimization Reagents - X-Ray Crystallography
  1. Research Essentials 基础科研
  2. Core Bioreagents - Research Essentials
  3. Life Science Reagents for Western Blotting - Core Bioreagents
  4. Buffers / Buffers Salts - Life Science Reagents for Western Blotting

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