Epichlorohydrin 环氧氯丙烷
CAS 106-89-8 MFCD00005132
化学结构图
SMILES: ClCC1CO1
化学属性
| Mol. Formula | C3H5ClO |
|---|---|
| Mol. Weight | 93 |
| Density | 1.183 |
| Refractive index | 1.4360 to 1.4400 |
| Boiling Point | 115-117 |
| Melting Point | -57 |
| Flash Point | 32°C(lit.) |
| TSCA | Yes |
| Autoignition Point | 779 °F |
| Vapor Density | 3.2 (vs air) |
| Vapor Pressure | 13.8 mmHg ( 21.1 °C) |
| Solubility | 微溶于水，可混溶于醇、醚、四氯化碳、苯。 |
| Danger-Level | 甲类 |
别名和识别编码
| Chemical Name | Epichlorohydrin |
|---|---|
| Synonym | Oxirane, 2-(chloromethyl) 3-环氧丙烷 2-(chloromethyl)oxirane {Chem { 3-Chloro-1,2-propylene oxide (chloromethyl)ethyleneoxide alpha-Epichlorohydrin RCRA waste number U041 3-chloro-1,2-epoxypropane 1-Cloro-2,3-epossipropano dl-α-Epichlorohydrin (±)-环氧氯丙烷 ALPHA-EPICHLOROHYDRIN 1-Chloor-2,3-epoxy-propaan gamma-Chloropropylene oxide (+/-)-2-(CHLOROMETHYL)OXIRANE {Ch 1,2-Epoxy-3-chloropropane 1-CHLORO-2,3-EPOXYPROPANE {uni_hambur (±)-2-(氯甲基)环氧乙烷 1-氯-2,3-环氧丙烷 氯甲代氧丙环 (Chloromethyl)-oxirane EPICHLOROHYDRIN Epicloridrina (Chloromethyl)ethylene oxide (DL)-alpha-Epichlorohydrin 1-Chloro-2,3-epoxypropane |
| CAS Number | 106-89-8 |
| EC Number | 203-439-8 |
| Beilstein Registry Number | 79785 |
| MDL Number | MFCD00005132 |
| PubChem Substance ID | 7835 |
| Reaxys-RN | 79785 |
| Merck Number | 3611 |
| Chemical Name Translation | 环氧氯丙烷 |
| Wiswesser Line Notation | T3OTJ B1G |
| LabNetwork Molecule ID | LN00194743 |
| InChI | InChI=1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} 2000/60/EC, Additional Standards, Alpha Sort, Analytical Standards, Chromatography, E, E-L, Environmental Standards, European Community: ISO, DIN and DL 152, Food and Cosmetic Component Standards, Method and Regulation Specific, Organic Pollutant Standards, Standards for Personal Care and Cosmetic Products, Volatile & Semivolatile Standards, Volatiles/ Semivolatiles, neats, prohibited substances (EU-REGULATION No 1223/2009), 分析/色谱
- {SNA} 2000/60/EC, Alpha Sort, Analytical Standards, Analytical/Chromatography, Chromatography, E-L, Envi
产品应用
- 有机合成的原料;有机溶剂（树脂、树胶、纤维素醚等的溶剂）;也用作增塑剂、表面活性剂等
相关文献及参考
- Short: II/14a
- Merck:14,3611 Beilstein:17,6
- Reaction with primary amines provides a one-step route to 3-azetidinols: J. Org. Chem., 55, 2920 (1990):
- Merck:14,3611
- The preparation of glycidyl ethers, often carried out in two steps, via the ring-opened chlorohydrin ether and subsequent ring-closure with base, can be achieved as a single step, under phase-transfer conditions: Synthesis, 117 (1983). For extension to diglycidyl ethers of diols, see: Synthesis, 649 (1985).
- For use as an acid scavenger in bromination reactions, see: J. Am. Chem. Soc., 95, 4419 (1973).
- Short: II/2
安全信息
GHS Symbol
- H226 Flammable liquid and vapour 易燃液体和蒸气
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H350 May cause cancer 可能致癌
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H301+H311+H331
- H331 Toxic if inhaled 吸入中毒
- H311 Toxic in contact with skin 皮肤接触中毒
- H301 Toxic if swallowed 吞食有毒
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P304+P340+P310
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P403+P233
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P330+P331+P310
- P303+P361+P353
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P301+P310
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P308+P311
- R45 May cause cancer 可能致癌
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R10 Flammable 易燃
- R34 Causes burns 会导致灼伤
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 60 gm/kg/81W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors REFERENCE : GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For pu
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 42525 mg/kg/81W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors REFERENCE : NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 32,270,1981
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5150 mg/kg/2Y-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Endocrine - tumors REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 36,325,1985
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 85050 mg/kg/81W-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors REFERENCE : NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 32,270,1981
TYPE OF TEST : TC - Toxic concentratio
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - urine volume increased REFERENCE : AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946- Volume(issue)/page/year:
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,64,1982
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,63,1948
TYPE OF TEST : LDLo - Lowest published lethal dose RO
TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 72 gm/m3/9M TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1-
TYPE OF TEST : LC50
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 1 uL/plate REFERENCE : PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981- Volume(issue)/page/year: 1,387,1981
TYPE OF TEST : Mutation test systems - not
{hTYPE OF TEST : Gene conversion and mitotic recombination TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 65 mmol/L REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 18,1337,1980
TYPE OF TEST : Sperm Morphology ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 50 mg/kg REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 53,71,1983
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Mold - Neurospora crassa DOSE/DURATION : 150 mmol/L REFERENCE : STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972- Volume(issue)/page/year: 11,223,1979
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 10 umol/L/24H REFERENCE : STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972- Volume(issue)/page/year: 11,223,1979
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 300 umol/L REFERENCE : SinJF# P
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 1200 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 9,87,1982
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 288 mg/kg SEX/DURATION : male 23 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 12,54,1991
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 180 mg/kg SEX/DURATION : male 12 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 226,87,1970
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 75 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paterna
其他信息
- 有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、三氯乙烯和四氯化碳等混溶，微溶于水，在20℃时，水中溶解度60g/L (10°C)。该品与水形成共沸物含水29%。不能与石油烃混溶。
- 中毒:环氧氯丙烷主要经呼吸道进入人体，也可经皮肤吸收。有强烈的刺激作用及致敏作用，并有轻度麻醉及原浆毒作用。高浓度液体和蒸气对眼和呼吸道粘膜有强烈刺激作用，可引起眼刺痛、流泪、咽干、咳嗽、喘息性支气管炎以及肝肾损害，严重患者可引起粘膜坏死脱落性气管炎、支气管周围炎、肺水肿和急性肾脏损害。液体污染皮肤，可出现灼伤、大疱形成及湿疹。长期吸入低浓度的蒸气，可引起四肢肌肉酸痛、腓肠肌压痛、腿软无力、全身乏力及头晕、失眠、多梦等。严重者可发生多发性神经炎。
- 方法一:其制备方法是以丙烯为原料，在500℃氯化生成氯丙烯，氯丙烯在25～35℃温度下，与次氯酸反应，得到2，3-二氯丙醇和1，2-二氯丙醇，然后将该混合物加入20％石灰
- 方法二:工业上主要用丙烯氯化法制取。丙烯和氯气进行高温氯化得到烯丙基氯，再经次氯酸化制取二氯丙醇，进而皂化制得环氧氯丙烷。原料消耗定额：丙烯（100%）640kg/t、氢氧化钠（100%）150kg/t、氯气2070kg/t、副产D-D混剂140kg/t、氢氧化钙（100%）1020kg/t。
- 常规方法:因氯化铁或氯化锡等能促进环氧氯丙烷自聚反应的发生，故宜贮存在干燥清洁的镀锌桶中，每桶2
- 防护措
- 有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、三氯乙烯和四氯化碳等混溶，微溶于水，在20℃时，水中溶解度60g/L (10°C)。该品与水形成共沸物，含水28%。不能与石油烃混溶。
- 图谱信息:环氧氯丙烷(106-89-8)核磁图( 13 CNMR) 环氧氯丙烷(106-89-8)质谱(MS) 环氧氯丙烷(106-89-8)红外图谱(IR2) 环氧氯丙烷(106-89-8)核磁图( 1 HNMR) 环氧氯丙烷(106-89-8)Raman光谱 环氧氯丙烷(106-89-8
- TCI Shanghai:环氧氯丙烷 Epichlorohydrin,>;99.0%(GC)(106-89-8)
- 有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、三氯乙烯
- 概述:环氧氯丙烷为无色油状液体，有刺激性如醚和氯仿的气味，易燃，易挥发，有毒性和麻醉性。相对密度1.1812，熔点-25.6℃
- 有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、三氯乙烯和四氯化碳等混溶，微溶于水，在20℃时，水中溶解度60g/L (10°C)。该品与水形成共沸物含水31%。不能与石油烃混溶。
- 爆炸物危险特性:与空气混合可爆
- 有类似氯仿的气味。易挥发。不稳定。能与乙醇、乙醚、氯仿、
- 用途一:用作有机合成的原料，也用作溶剂、增塑剂、表面活性剂等
- MSDS 信息:3-氯-1,2-环氧丙烷(106-89-8).msds
- MOL 文件:106-89-8.mol
- 职业标准:TWA 10 毫克/ 立方米；STEL 20 毫克/立方米
- 可燃性危险特性:遇明火、高温、氧化剂较易燃; 燃烧产生有毒氯化物烟雾
- {ALD
- 用途二:用作有机溶剂
- 类别:易燃液体
- 用途五:环氧氯丙烷是合成甘油中间体，也是环氧树脂、硝化甘油炸药、玻璃钢、电绝缘制品的主要原料。并用作纤维素酯、树脂和纤维素醚的混剂。也是生产表面活性剂、医药、农药、涂料、胶粘剂、离子交换树脂、增塑剂、甘油衍生物、缩水甘油衍生物以及氯醇橡胶的原料。以环氧氯丙烷与双酚A为主要原料制取的各类环氧树脂具有粘合性高、收缩性小、耐化学腐蚀、稳定性好等特点，广泛用作涂料、粘合剂、增强材料和浇铸材料等。以环氧氯丙烷为原料生产的氯醇橡胶是橡胶的新品种，在一般油和普通溶剂中不易膨胀，在低温无增塑剂存在下具有较大的挠性，具有优于丁腈、氯丁和丁基橡胶的某些特有的功能。
- {Chem
- 急性毒性:口服- 大鼠 LD50: 90 毫克/ 公斤; 口服- 小鼠 LD50: 195 毫克/ 公斤
京ICP备2020036287号