N-(Trimethylsilyl)Imidazole N-(三甲基硅基)咪唑
CAS 18156-74-6 MFCD00005280
化学结构图
SMILES: C[Si](C)(C)N1C=NC=C1
化学属性
| Mol. Formula | C6H12N2Si |
|---|---|
| Mol. Weight | 140 |
| Boiling Point | 93-94 |
| TSCA | T |
| Density | 0.956 |
| Refractive index | 1.4740 to 1.4780 |
| Flash Point | 5°C(lit.) |
| Melting Point | -42°C |
| Solubility | 分解 |
别名和识别编码
| Chemical Name | N-(Trimethylsilyl)Imidazole |
|---|---|
| CAS Number | 18156-74-6 |
| Alfabeta Name | TRIMETHYLSILYLIMIDAZOLE 1()- |
| MDL Number | MFCD00005280 |
| Synonym | 1-(Trimethylsilyl)-1H-imidazole 1-(Trimethylsilyl)imidazole 1-(三甲基硅基)咪唑 N-(Trimethylsilyl)imidazole N-三甲基硅烷基咪唑 NSC 139860 TMSI TSIM Trimethylimidazosilane |
| Beilstein Registry Number | 606148 |
| EC Number | 242-040-3 |
| PubChem Substance ID | 87576564 |
| Reaxys-RN | 606148 |
| Chemical Name Translation | N-(三甲基硅基)咪唑 |
| Wiswesser Line Notation | T5N CNJ A-SI-1&1&1 |
| LabNetwork Molecule ID | LN00117274 |
| InChIKey | YKFRUJSEPGHZFJ-UHFFFAOYSA-N |
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分类
- {SNA} Building Blocks, C3 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Imidazoles, Organometallic Reagents, Organosilicon, Others
- {SNA} Building Blocks, C3 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Imidazoles
- {uni_hamburg} no charge; nitrogen heterocycle; aromatic; 5ring; 1fragment
- Heterocycles
- Pharmaceuticals
- {SNA} Alcohols, Analytical Reagents, Analytical/Chromatography, Derivatization Reagents,
- {SNA} Alcohols, Derivatization Reagents, Derivatization Reagents GC, GC Derivatization Reagents, by Application, Reagents for Silylation, Silylation Reagents, 分析/色谱, 分析试剂
- {SNA} Building Blocks,
产品应用
- 甲硅烷基化试剂，在氨基存在的条件下保护羟基基团。抗菌素中间体。
相关文献及参考
- Beilstein: 23,V,4,456
- Short: III/35F
- Powerful silylating agent (see Appendix 4) for a wide range of functional groups. O-Silylation in the presence of TBAF (0.02 equiv.) occurs under very mild conditions: Tetrahedron Lett., 35, 8409 (1994).
- Shin, H. et al.: Chromatographia, 63, 77 (2006); Birkemeyer, C. et al.: J. Chrom., 993, 89 (2003);
安全信息
- R11 Highly flammable 非常易燃
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S33 Take precautionary measures against static discharges 对静电采取预防措施；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S37 Wear suitable gloves 戴适当手套；
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
GHS Symbol
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241+P242+P243
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P332+P313+P362+P364
- P303+P361+P353
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P370+P378
- P403+P235
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H319 Causes serious eye irritation 严重刺激眼睛
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1000 mg/kg/I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,495,1975
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 750 mg/kg TOXIC EFFECTS : Immunological Including Allergic - decreased immune response REFERENCE : StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 Volume(issue)/page/year: 27MAY1975
其他信息
- 水中分解。
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