2(5H)-Furanone 2(5H)-呋喃酮

CAS 497-23-4 MFCD00005376

化学结构图

497-23-4
SMILES: O=C1C=CCO1

化学属性

Mol. FormulaC4H4O2
Mol. Weight84.07
Refractive index1.4680 to 1.4720
Boiling Point203.7°C at 760 mmHg
Density1.185
Melting Point4-5°C
Flash Point87.3°C
TSCANo
Stability对热、光线和空气敏感

别名和识别编码

Chemical Name2(5H)-Furanone
CAS Number497-23-4
Alfabeta NameFURANONE H25()-
MDL NumberMFCD00005376
Synonym 2(5H)-Furanone {LY} 2(5H)-Furanone {} {LY} 2(5H)-Furanone {} {} {LY} 2(5H)-Furanone {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2(5H)-Furanone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID10341
EC Number207-839-3
Beilstein Registry Number383585
Reaxys-RN383585
Chemical Name Translation2(5H)-呋喃酮
LabNetwork Molecule IDLN00171454
InChIInChI=1S/C4H4O2/c5-4-2-1-3-6-4/h1-2H,3H2
Canonical SMILESO=C1OCC=C1
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分类

  • {SNA} Building Blocks, Carbonyl Compounds, Chemical Synthesis, Lactones, Organic Building Blocks
  • {SA} Building Blocks, C4 to C7, Chemical Synthesis, Furans, Heterocyclic Building Blocks
  • {SNA} Building Blocks, C4 to C7, Chemical Synthesis, Furans, Heterocyclic Building Blocks
  • {uni_hamburg} no charge; oxygen heterocycle; alicycle; 5ring; ester; lactone; 1fragment

产品应用

  • 一种多功能试剂,用于Michael加成反应和Michael-Aldol 反应。

相关文献及参考

  • Short: EINECS
  • Short: III/35E
  • Beilstein:17,249
  • Short: II/14a
  • Reaction with lithiated o-methylbenzophenone derivatives gives fused tricyclic products which are readily converted to arylnaphthofuranone lignans: J. Chem. Soc., Perkin 1, 3013 (1995):

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSLU3453000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Signal word Warning {} {} {} {} {} {} {TCI}
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 2 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   ACENA7 Acta Endocrinologica (Copenhagen).  (Periodica, Skolegade 12 E,
   DK-2500 Valby, Denmark) V.1-    1948-  Volume(issue)/page/year: 123,571,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 2 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Endocrine - changes in luteinizing hormone
REFERENCE :
   ACENA7 Acta Endocrinologica (Copenhagen).  (Periodica, Skolegade 12 E,
   DK-2500 Valby, Denmark) V.1-    1948-  Volume(issue)/page/year: 123,571,1990

其他信息

  • 2(5H)-呋喃酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1078 γ-巴豆酸内酯 gamma-Crotonolactone 5ML 882元 2014/06/02 C1078 γ-巴豆酸内酯 gamma-Crotonolactone 25ML 2960元 2010/05/25 L13142 2(5H)-呋喃酮, 98% 2(5H)-Furanone, 98% 25g 8120元
  • Alfa Aesar:2(5H)-呋喃酮,98% 2(5H)-Furanone, 98%(497-23-4)
  • 海关编码:29322980
  • MOL 文件:497-23-4.mol
  • 用途一:常用试剂,用于Michael加成反应和Michael-Aldol 反应。
  • TCI Shanghai:γ-巴豆酸内酯 gamma-Crotonolactone,>;93.0%(GC)(497-23-4)
  • Sigma Aldrich:497-23-4(sigmaaldrich)
  • Hazard Note:Irritant
  • F:8-10
  • MSDS 信息:Furan-2(5H)-one(497-23-4).msds
  • Chiral urea compounds catalyzed hetero-Michael addition reaction of 2(5H)-furanone (γ-crotonolactone) to pyrrolidine.The quorum sensing inhibition activity by 2(5H)-furanone was studied using bioindicator strains.

系列性分类


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