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• 试剂商城
• 直接询价

分类

• {SNA} Building Blocks, C4 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines
• {SNA} Additio
• {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
• {SNA} Analytical Standards,
• {SNA} Additional Standards, Alpha Sort, Analytical Standards, Chemical Class, Chromatography, Environmental Standards, Heterocyclics, M, M-P, Nitrogen containing,
• {SNA} Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Chemical Class, Chromatography,

产品应用

• 有机合成、制药、合成纤维等的中间体。

相关文献及参考

• For preparation of a reagent for the high-yield reduction of esters to aldehydes, see Sodium bis(2-methoxyethoxy)­aluminum hydride, A13292. Similarly, addition of the hydrochloride to Lithium aluminum hydride, A18116, gives a complex which can reduce carboxylic acids to aldehydes: J. Org. Chem., 49, 2279 (1984).
• Short: III/20a
• Beilstein: 23,V,1,82
• The N-lithio-derivative effects the O-alkyl cleavage of aromatic ortho-alkoxyaldehydes or ketones, without the need for carbonyl protection: Synth. Commun., 18, 191 (1988).
• Short: III/38B

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2830 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1490 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   23,95,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1450 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - changes in motor activity (specific assay)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   To

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2740 mg/m3/2H
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - muscle contraction or spasticity
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 11,123,1969

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其他信息

• 蒸气密度:3.5 (vs air)
• N-甲基哌嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30201818 N-甲基哌嗪 500ml 139元 2011/04/16 M0553 N-甲基哌嗪 1-Methylpiperazine 25ML 153元 2011/04/16 M0553 N-甲基哌嗪 1-Methylpiperazine 500ML 895元
• Hazard Note:Flammable/Toxic/Corrosive/Store under nitrogen
• {Chem
• {
• 下游产品:佐匹克隆 --> 2-(4-甲基哌嗪-1-基)嘧啶-5-甲醛 --> 2-(4-甲基哌嗪-1-基)嘧啶-5-甲酰胺 --> 2-(4-甲基哌嗪-1-基)嘧啶-5-胺 --> 2-(4-甲基哌嗪-1-基)嘧啶-5-甲醇 --> 2-(4-甲基哌嗪-1-基)嘧啶-5-甲酰氯 --> 2-(4-甲基哌嗪-1-基)嘧啶-5-甲酸 --> 2-(4-甲基哌嗪-1-基)嘧啶-5-甲腈 --> 3-(4-甲基哌嗪-1-基甲基)苯甲酸 --> 2-(4-甲基哌嗪-1-基)嘧啶-5-甲酸乙酯 --> 4-(4-甲基哌嗪-1-基甲基)苯胺 --> (2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-基)甲胺 --> 2-肼基-1-(4-甲基哌嗪-1-基)乙酮 --> 3-肼基-1-(4-甲基哌嗪-1-基)-1-丙酮 --> 氯环嗪 --> 2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-甲醛 --> 左氧氟沙星 --> 2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-甲酰胺 --> (2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-基)甲醇 --> 2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-胺 --> 2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-甲腈 --> 4-(4-甲基哌嗪)苯胺 --> 2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-甲酸 --> 1-甲基-4-(4-硝基苯基)哌嗪 --> 2-(4-甲基哌嗪-1-基)-6-三氟甲基嘧啶-4-甲酸乙酯 --> 4-甲基-1-哌嗪乙酸 --> 氯氮平 --> 1-甲基-4-(3'-硝基苯基)哌嗪 --> 1-金刚烷乙胺 --> 1-氨基-4-甲基哌嗪 --> 4-甲基-1-甲酰基哌嗪 --> 3-(4-甲基哌嗪-1-基)苯胺 --> 阿齐利特 --> 1-甲基哌嗪盐酸盐
• 海关编码:29335995
• 图谱信息:N-甲基哌嗪(109-01-3)红外图谱(IR2) N-甲基哌嗪(109-01-3)红外图谱(IR1) N-甲基哌嗪(109-01-3)质谱(MS) N-甲基哌嗪(109-01-3)核磁图( 13
• Alfa Aesar:N-甲基哌嗪,98% 1-Methylpiperazine, 98+%(109-01-3)
• 有氨样气味。有吸湿性。能与水混溶，易溶于乙醇、乙醚和丙酮。易燃。有毒。有腐蚀性。
• {Che
• Sigma Aldrich:109-01-3(sigmaaldrich)
• 用途二:有机合成中间体。在医药工业中用
• 方法一:由六水哌嗪经甲基化反应而得。将六水哌嗪及盐酸加入反应锅中，加热至45℃，滴加甲酸和甲醛的混合液。加毕，在50℃左右反应2-3h，再升温回流，至二氧化碳气体不再逸出为止。冷却至80℃，加入盐酸，加热蒸酸至干。稍冷后加入甲醇，加热回流30min，趁热过滤（滤渣为哌嗪二盐酸盐）。滤液回收甲醇至尽，残液加入氢氧化钠溶液至pH=14，蒸馏，得含水甲基哌嗪。加苯加热回流带水至尽，分馏，收集132-140℃馏分，得无水甲基哌嗪。收率约50%。
• Acros Organics:N-甲基哌嗪 1-Methylpiperazine, 99+%(109-01-3)
• TCI Shanghai:N-甲基哌嗪 1-Methylpiperazine,>;98.0%(GC)(109-01-3)
• 敏感性:Hygroscopic
• 上游原料:甲醇 --> 二氧化碳 --> 哌嗪 --> 哌嗪(六水) --> 哌嗪二盐酸盐
• 用途一:用于制取抗菌类药物甲哌利福霉素