N-Aminoethylpiperazine N-氨乙基哌嗪

CAS 140-31-8 MFCD00005971

化学结构图

140-31-8
SMILES: NCCN1CCNCC1

化学属性

Mol. FormulaC6H15N3
Mol. Weight129.21
Refractive index1.4950 to 1.5010
Boiling Point222°C(lit.)
Density0.985
Flash Point93°C(lit.)
TSCAYes
Melting Point-19°C
Vapor Density4.4 (vs air)
Vapor Pressure0.05 mmHg ( 20 °C)
Solubility可溶
Appearance 无色透明液体。沸点218-222℃，相对密度0.985（20℃），折光率1.5000（20℃），闪点93℃。

别名和识别编码

Chemical NameN-Aminoethylpiperazine
CAS Number140-31-8
Alfabeta NamePIPERAZINYLETHANAMINE 21()---
MDL NumberMFCD00005971
Synonym 氨乙基哌嗪, N-（2-氨乙基）哌嗪, 氨基乙基对二氮己环 AKOS BBS-00004342 {Chemicalbook} N-AMINOETHYLPIPERAZINE 1-(2-aminoethyl)-piperazin 2-Piperazinoethylamione 1-(2-AMINOETHYL)PIPERAZINE 1-胺乙基六氫吡【口+井】 N-氨基乙基哌嗪 N-(2-AMINOETHYL)PIPERAZINE N-(2-Aminoethyl)piperazine 1-(2-Aminoethyl)piperazine; 1-Piperazineethanamine; 2 Piperazine, 1-(2-aminoethyl)- N-AEP Usaf do-46 {uni_hambu 氨基乙基哌嗪 4-(2-Aminoethyl)piperazine N-(2-氨乙基)哌嗪 1-(2-Aminomethyl)piperazine Aminoethylpiperazine 1-Aminoethylpiperazine 2-piperazin-1-ylethylamine AEP AMINOETHYLPIPERAZINE 氮乙基哌嗪 1-aminoethylpiperazine 1-2-Aminoethyl piperazine 2-Piperazinylethylamine D.E.H. 39 2-PIPERAZIN-1-YL-ETHYLAMINE {uni_ 1-Piperazineethylamine 1-Piperazine ethanamine TIMTEC-BB SBB004229 N-Aminoethylpiperazine USAF DO-46 1-Piperazineethanamine 氨基乙基对二氮己环 1-(2-Aminoethyl)-piperazin 2-PIPERAZINOETHYLAMINE 2-(1-Piperazinyl)ethylamine 2-Piperazinoethylamin 2-(1- N-(2-AMINOETHYL)PIPERAZIN N-(beta-Aminoethyl)piperazine Ancamine AEP N-氨乙基哌嗪 1-(β-Aminoethyl)piperaz {Chemicalboo 2-(1-哌嗪基)乙胺 1-2-氨乙基哌嗪 N-氨乙基哌嗪(AEP) 1-(2-Aminoethyl) piperazine N-(Aminoethyl)piperazine 2-(1-Piperazino)ethylamine N-(β-Aminoethyl)piperazine 1-Piperazinaminoethan 2-piper {Chemicalbook
PubChem Substance ID87561957
EC Number205-411-0
Beilstein Registry Number23(3/4)298
Reaxys-RN104363
Chemical Name TranslationN-氨乙基哌嗪
Wiswesser Line NotationT6M DNTJ D2Z
LabNetwork Molecule IDLN00176273
InChIInChI=1S/C6H15N3/c7-1-4-9-5-2-8-3-6-9/h8H,1-7H2
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分类

  • {SNA} Building Blocks, C4 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines
  • Building Blocks, C4 to C8, Chemical Synthesis, Heterocyclic Building Blocks, Piperazines
  • {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 6RingOnly; 6ring; 1fragment

产品应用

  • 用在各种反应中，用于研究缓蚀、生物活性和各种金属配体对催化的影响.

相关文献及参考

  • Short: IV/13A1
  • 3. Tetrahedron 48 , 1999, (1992)
  • Beilstein:23(3/4)298

安全信息

Warnings 危化品目录(2015) IRRITANT
GHS Symbol
WGK Germany2
Hazard Codes C
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H312 Harmful in contact with skin 皮肤接触有害
  • H227 Combustible liquid 可燃液体
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTK8050000
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P304+P340
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P304+P340+P310
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P403+P235
  • P301+P330+P331
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P303+P361+P353+P310+P363
Signal word Danger Warning
UN Number UN2815 2815 UN 2815 8/PG 3
Risk Statements
  • R34 Causes burns 会导致灼伤
  • R52/53
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Storage condition Air Sensitive
Packing GroupIII
Hazard Class8/6.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 880 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 6/13/1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2140 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 6/13/1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 320,31,1994

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 uL/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 4,390,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 125 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 320,31,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1680 mg/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 51(10),66,1986

Restrict 危险品

其他信息

  • 用途一:医药中间体。
  • 毒性分级:中毒
  • 灭火剂:雾状水、干粉、二氧化碳、抗醇泡沫
  • Alfa Aesar:N-(2-氨乙基)哌嗪,98% 1-(2-Aminoethyl)piperazine, 98%(140-31-8)
  • 爆炸物危险特性:与空气混合可爆
  • 方法一:该品是二氯乙烷和氨反应生产乙二胺类产品时的副产品。原料消耗定额：二氯乙烷2100kg/t、液氨620kg/t、烧碱（42%）4143kg/t。
  • Sigma Aldrich:140-31-8(sigmaaldrich)
  • 刺激数据:皮肤-兔子 5 毫克/24小时 重度; 眼睛-兔子 20 毫克/24小时 中度
  • 海关编码:29335995
  • 急性毒性:口服-大鼠 LD50: 2110 毫克/公斤; 腹注-小鼠 LD50: 250 毫克/公斤
  • N-氨乙基哌嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0304 N-(2-氨乙基)哌嗪 N-(2-Aminoethyl)piperazine 25ML 152元 2014/06/02 A0304 N-(2-氨乙基)哌嗪 N-(2-Aminoethyl)piperazine 500ML 355元 2010/06/21 400760025 N-氨乙基哌嗪 1-(2-Aminoethyl)piperazine 99% 2.5 KG 2401元
  • MSDS 信息:2-Piperazin-1-ylethylamine(140-31-8).msds
  • 蒸气密度:4.4 (vs air)
  • TCI Shanghai:1-(2-氨乙基)哌嗪 N-(2-Aminoethyl)piperazine,>;99.0%(GC)(140-31-8)
  • 类别:腐蚀物品
  • 图谱信息:N-氨乙基哌嗪(140-31-8)红外图谱(IR1)
  • 可燃性危险特性:遇热, 近火, 遇火星或遇强氧化剂易燃; 遇热分解有毒氧化氮气体
  • 下游产品:乙二胺 --> N-苄氧羰基-3-氨基丙醛
  • 敏感性:Air Sensitive
  • MOL 文件:140-31-8.mol
  • Acros Organics:氨乙基哌嗪 1-(2-Aminoethyl)piperazine, 97%(140-31-8)
  • 上游原料:碳酸钾 --> 氨 --> 哌嗪 --> 二氯乙烷 --> 2-氯乙胺盐酸盐
  • 用途二:用于各种腐蚀抑制、生物活性和金属配体对分析的效果等方面的研究。
  • 储运特性:库房通风低温干燥; 与酸分开存放
  • 蒸气压:0.05 mm Hg ( 20 °C)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Oxazolines/Oxazolidines 恶唑啉/恶唑烷
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperazines 哌嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Piperazines 哌嗪
  5. C4 to C8 - Piperazines