Piperidine 哌啶(易制毒)

CAS 110-89-4 MFCD00005979

化学结构图

110-89-4
SMILES: c1ccncc1

化学属性

Mol. FormulaC5H11N
Mol. Weight85.15
Refractive indexn20/D 1.452(lit.)
Boiling Point106 °C(lit.)
Density0.862 g/mL at 20 °C(lit.)
Melting Point-13 °C (lit.)
Flash Point3°(37°F)
TSCAYes
Vapor Density3 (vs air)
Vapor Pressure23 mmHg ( 20 °C)
SolubilityMISCIBLE

别名和识别编码

Chemical NamePiperidine
Synonym HEXAHYDROPYRIDINE 聚丙烯(无规共聚) Pentamethyleneimine AKOS BBS-00003659 六氢吡啶 hexahydropyridinepentamethyleneimine Hexazane azacyclohexane PENTAMETHYLENEIMINE Pyridine, hexahydro- Pentamethyleneamine Pentamethylenimine Cypentil 1-Oxa-4-azacyclohexane; Azacyclohexane; Cyclopentimine; Hexahydropyridine; Pentamethyleneimine PIP PIPERIDINE PPR hexahydro-pyridin 一氮六环 Cyclopentimine Piperidin 派盯 Ⅲ型聚丙烯 hexahydroazine Hexahydropyridine 一氮六圜 Pentamethylenimin {Chemica PIPERIDINE ON RASTA RESIN 哌啶
CAS Number110-89-4
PubChem Substance ID8082
EC Number203-813-0
Beilstein Registry Number102438
MDL NumberMFCD00005979
Merck Number14,7468
Chemical Name Translation哌啶(易制毒)
Wiswesser Line NotationT6MTJ
InChIInChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
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分类

  • {SNA} Building Blocks, C5 to C7, Chemical Synthesis, Heterocyclic Building Blocks, Humulus lupulus (Hops), Nutrition Research, Phytochemicals by Plant (Food/Spice/Herb), Piperidines
  • {SNA} Acids & Bases, Bases, Building Blocks, C5 to C7, Chemical Synthesis,

相关文献及参考

  • Merck 14 ,7468
  • Beil. 20 ,V,2,3
  • Fieser 1 ,886 / Fieser 2 ,332 / Fieser 4 ,393 / Fieser 6 ,472 / Fieser 7 ,293
  • Aldrich MSDS 1 , 1500:B / Corp MSDS 1 (2), 2845:A / FT-IR 1 (1), 358:C / FT-IR 2 (1), 558:B / FT-NMR 1 (1), 563:B / IR-Spectra (2), 189:F / IR-Spectra (3), 210:G / NMR-Reference 2 (1), 314:A / RegBook 1 (1), 381:E / Sax 6 , 2236 / Sigma FT-IR 1 (2), 853:C / Structure Index 1 , 54:C:3
  • Base catalyst in the Doebner modification of the Knoevenagel condensation; see Malonic acid, A11526.
  • Widely used for cleavage of Fmoc protecting groups: J. Org. Chem., 52, 1197 (1987); Tetrahedron Lett., 34, 6135 (1993). See Appendix 6.
  • For preparation of the piperidine enamine of cyclooctanecarboxaldehyde, and its subsequent use in the synthesis of spirohexadienones, see: Org. Synth. Coll., 7, 473 (1990).

安全信息

GHS Symbol
WGK Germany1
Hazard Codes F,T F;T T,F
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H331 Toxic if inhaled 吸入中毒
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H311+H331
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSTM3500000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P304+P340+P310
  • P370+P378
  • P403+P235
  • P303+P361+P353
Signal word Danger
UN Number 2401 UN2401 UN 3286 3/PG 2
Risk Statements
  • R34 Causes burns 会导致灼伤
  • R23/24 Toxic by inhalation and in contact with skin 吸入及皮肤接触都有毒
  • R11 Highly flammable 非常易燃
  • R10 Flammable 易燃
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R52 Harmful to aquatic organisms 对水生生物有害
  • R24 Toxic in contact with skin 与皮肤接触有毒
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Storage condition Store in dark! Air Sensitive
Packing GroupI
Hazard Class8
Restrict 易制毒 {} 易制毒化学品
Warnings 危化品目录(2015) 危险化学品
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPMRAB Japanese Journal of Medical Sciences, Part 4:  Pharmacology. (Tokyo,
   Japan)  V.1-16, 1926-43. For publisher information, see JJPAAZ.
   Volume(issue)/page/year: 7,128,1933

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 4(2-3),345,1980

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6000 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 15,116,1979

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 8020 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,155,1988

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 5050 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 mg/m3/24H
SEX/DURATION            : female 4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 14,40,1975

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/m3/24H
SEX/DURATION            : female 4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 14,40,1975

其他信息

  • 下游产品:2-氯-6-甲基-3-吡啶甲腈 --> 6-溴-3-丁酰-2H-苯并吡喃-2-酮 --> 5-甲基-4-异恶唑磺酰氯 --> 2-氨基-5-硝基嘧啶 --> 米诺地尔 --> 四硫化双五亚甲基秋兰姆 --> 咳安定 --> 3-乙酰氨基香豆素 --> 6-氯-2-氧代-2H-苯并吡喃-3-羧酸 --> 芥子酸 --> 3-乙酰基-7-羟基-苯并吡喃-2-酮 --> 2,4,5-三甲氧基肉桂酸 --> 盐酸地芬尼多 --> 5-溴-2-氟肉桂酸 --> 4-乙氧基肉桂酸 --> 哌啶戊醇 --> 1,2,3,5-四氢-8-硫杂-5,7-二氮-环戊基[A]茚-4-酮 --> 7-羟基-2-氧代-2H-苯并吡喃-3-甲酸甲酯 --> 3-(三氟甲氧基)肉桂酸 --> 对氟肉桂酸 --> 3,5-二甲氧基肉桂酸 --> 3,4-(亚甲二氧)肉桂酸 --> 2-氨基环戊并[B!噻吩-3-甲酸乙酯 --> 丁香醛 --> 1-(2-氨乙基)哌啶 --> 2,3-萘基二缩醛 --> 2-氨基-6-甲基-4,5,6,7-四氢-1-苯并噻吩-3-甲酰胺 --> 3-(3-甲基-2-噻吩)丙烯酸 --> 2-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯 --> 2-氨基-5,6-二氢-4H-环戊烯并噻吩-3-甲酸甲酯 --> 甲苯哌丙酮 --> 磷酸苯丙哌林
  • FEMA:2908
  • 使用限量:FEMA(mg/kg):饮料3.0;糖果5.0;焙烤食品0.05~5.0;调味料0.05;汤(料)0.05。 适度为限(FDA,§172.515,2000)。
  • 可燃性危险特性:遇明火、高温、氧化剂易燃; 受热分解有毒氧化氮气体
  • 用途五:哌啶又称六氢吡啶,是杀菌剂苯锈啶和植物生长调节剂甲哌鎓的中间体。
  • 急性毒性:口服- 大鼠 LD50: 400 毫克/ 公斤; 口服- 小鼠 LD50: 30 毫克/ 公斤
  • 所属类别三:食品添加剂: 食用香料(增香剂): 天然等同香料和人造香
  • 用途四:六氢吡啶又称哌啶,是植物生长调节剂甲哌鎓的中间体。
  • {Chemicalb
  • 蒸气密度:3 (vs air)
  • 所属类别一:农药中间体: 杀菌剂中间体: 其他
  • 灭火剂:干粉、干砂、二氧化碳、泡沫
  • Alfa Aesar:哌啶,99% Piperidine, 99%(110-89-4)
  • 图谱信息:六氢吡啶(110-89-4)核磁图( 13 CNMR) 六氢吡啶(110-89-4)质谱(MS) 六氢吡啶(110-89-4)核磁图( 1 HNMR) 六氢吡啶(110-89-4)红外图谱(IR1)
  • 蒸气压:23 mm Hg ( 20 °C)
  • Sigma Aldrich:110-89-4(sigmaaldrich)
  • F:3-34
  • 类别:易燃液体
  • 六氢吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 AW29080701 哌啶;一氮六环; 胡椒环; 环五甲亚胺; 哌哔定; 六氢吡啶; 氮杂环己烷 sample 589元 2011/08/23 80104219 哌啶(易制毒-2) kg 155.5元 2011/08/23 80104216 哌啶(易制毒-2) 100ml 27元
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量(g/kg) 最大允许残留量(g/kg) 哌啶 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • 用途六:哌啶用于制造局部麻醉药、止痛药、杀菌剂、润湿剂、环氧树脂固化剂、橡胶硫化促进剂等。
  • 上游原料:钠 --> 氢 --> 哌啶盐酸盐
  • 参考质量标准:FCC,1996 含量 ≥98.0% 折射率 l.450~1.454 相对密度 0.858~0.862
  • 用途二:在有机合成中用作缩合剂及溶剂

系列性分类