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分类

• {SNA} Acids & Bases, Amine Monomers, Bases, Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Materials Science, Monomers, Organic Bases, Polymer Science, Staudinger Ligation, Synthetic Reagents, Tertiary Amines
• {SNA} Acids & Bases, Amine Monomers, Bases, Chemical Biology, Chemical Synthesis, Conjugation Chemistry: Azides, Alkynes and Other Reagents, Monomers, Organic Bases, Polymer Science, Staudinger Ligation, Synthetic Reagents, Tertiary Amines,
• {SNA} Acids & Bases,

产品应用

• An anti-fade reagent shown to scavenge free-radicals due to flurochrome excitation.

相关文献及参考

• Short: II/25D
• Merck: 14,9669
• Merck: 14,9669 Beilstein: 23,V,3,487
• In conjunction with palladium acetate and PEG-400 provides a reusable catalyst system for the Suzuki-Miyaura cross-coupling reaction of boronic acids: J. Org. Chem., 70, 5409 (2005).
• Forms a stable crystalline complex with H2O2, useful as an equivalent to "anhydrous" H2O2: reaction with TMS chloride gives bis(TMS) peroxide, a useful OH+-equivalent, e.g. in the conversion of aryllithiums to phenols: Synthesis, 633 (1986).
• Forms crystalline complexes with organolithium compounds: J. Am. Chem. Soc., 87, 3276 (1965), which show enhanced reactivity, e.g. in the high yield ɑ-metallation of thioanisole by n-BuLi: J. Org. Chem., 31, 4097 (1966).
• Dabco is a registered trademark of Air Products and Chemicals Inc.
• For further illustrative example, see: Org. Synth., 75, 106 (1997). Complete reaction often takes several days at ambient temperature, while heating causes lower yields. However, it is greatly accelerated by microwave irradiation: Synlett, 444 (1994). Superior results with reduced reaction times can be achieved in aqueous medium: J. Org. Chem., 66, 5413 (2001). The use as reaction medium of tetramethylene sulfone: Tetrahedron Lett., 45, 1183 (2004), or PEG-400: Tetrahedron Lett., 45, 5865 (2004) has also been advocated. Lithium perchlorate was found to increase the reaction rate dramatically: Tetrahedron Lett., 40, 1539 (1999), as was a catalytic amount of a metal triflate, particularly La or Sm; conventional Lewis acids were ineffective: J. Org Chem., 63, 7183 (1998). For asymmetric Baylis-Hillman reaction using (1S,2R)-(-)-10,2-Camphorsultam, A15897, as chiral auxiliary, see: J. Am. Chem. Soc., 119. 4317 (1997). See also 3-Quinuclidinol, B21503. For more recent discussion and comparison of different catalysts, see: J. Org. Chem., 692 (2003). In a reinterpretaion of the mechanism, a hemiacetal interemediate has been proposed: J.
• {uni_ha

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(5),67,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete.  (VEB
   Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
   Rep.)  V.1-    1955-  Volume(issue)/page/year: 20,393,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(5),67,1980

其他信息

• 易溶于水，水中溶解度: 46 g/100ml (26 C)， 溶于丙酮、苯及乙醇等常规有机溶剂，溶于戊烷、已烷、庚烷等直链烃类；暴露在空气中易吸湿潮解并结块，能吸收空气中的CO2 并发黄。
• 用途三:主要用作聚氨酯发泡（硬泡、软泡）催化剂。可以直接使用，也可以配成A―33后使用。还有用作农药生产的引发剂（如六氨吡啶的引发剂），以及无氰电镀添加剂。该产品呈强碱性、低毒，有刺激性，使用时应穿戴防护用品。
• 方法一:将1，2-二氯乙烷和氨水送入管式反应器中，于150-250℃、392kPa压力下进和热压氨化反应。反应液以碱中和得到混合游离胺，经浓缩除去氯化钠，然后将粗吕减压蒸馏，收集不同馏分进行分离。在获得该品同时，并联产乙二胺、二亚乙基三胺、三亚乙基四胺、四亚乙基五胺和多亚乙基多胺。从生产六水哌嗪的母液中经分馏可得该品，第生产100t六水哌嗪可得六水三亚乙基二胺约3-4t。
• 三乙烯二胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30184062 三乙烯二胺 250g 79.6元 2011/04/16 D0134 1,4-二氮杂二环[2.2.2]辛烷 1,4-Diazabicyclo[2.2.2]octane 25G 190元 2011/04/16 D0134 1,4-二氮杂二环[2.2.2]辛烷 1,4-Diazabicyclo[2.2.2]octane 500G 1320元
• MSDS 信息:1,4-Diazabicyclo[2.2.2]octane(280-57-9).msds
• TCI Shanghai:1,4-二氮杂二环[2.2.2]辛烷 1,4-Diazabicyclo[2.2.2]octane,>;98.0%(T)(280-57-9)
• MOL 文件:280-57-9.mol
• 上游原料:乙二胺 --> 氯乙烷 --> 二乙烯三胺 --> 哌嗪(六水) --> 三乙烯四胺 --> 多乙烯多胺 --> 四亚乙基五胺
• 用途二:用于制取聚氨酯类泡沫塑料的催化剂和石油添加剂。
• Alfa Aesar:1,4-二偶氮双环［2.2.2］辛烷,98% 1,4-Diazabicyclo[2.2.2]octane, 98%(280-57-9)
• 下游产品:双二苯基磷酰联萘 --> 5-溴嘧啶-2-羧酸 --> 苯磺隆 --> 1,1'-联萘-2,2'-双二苯膦 --> 双二苯基磷酰联萘 --> 脱氢乙酸 --> S-(-)-1,1'-联萘-2,2'-双二苯膦 --> R-(+)-1,1'-联萘-2,2'-双二苯膦 --> 2-溴甲基丙烯酸乙酯 --> 2-氯-3-氟异烟酸 --> 3-氟吡啶-2-羧酸 --> 5-溴-2-氰基嘧啶
• Sigma Aldrich:280-57-9(sigmaaldrich)
• 蒸气压:2.9 mm Hg ( 50 °C)
• F:3
• Acros Organics:1,4-二叠氮双环[2.2.2]辛烷/三乙烯二胺 1,4-Diazabicyclo[2.2.2]octane, 97%(280-57-9)
• 用途一:可用于聚氨酯泡沫体、弹性体及涂料等多种制品的生产
• 海关编码:29335920
• 敏感性:Hygroscopic