CAS 88-73-3 MFCD00007061-2-Chloronitrobenzene 2-硝基氯苯 -LabNovo

2-Chloronitrobenzene 2-硝基氯苯

CAS 88-73-3 MFCD00007061

化学结构图

SMILES: O=[N+]([O-])c1ccccc1Cl

化学属性

Mol. Formula	C6H4ClNO2
Mol. Weight	158
Autoignition Point	500 °F
Vapor Density	5.4 (vs air)
Boiling Point	246°C(lit.)
Vapor Pressure	0.04 mmHg ( 25 °C)
Density	1.348 g/mL at 25 °C(lit.)
Melting Point	31-33 °C(lit.)
Flash Point	126°(258°F)
TSCA	Yes
Solubility	0.43 G/L (20 ºC)
Stability	对湿度敏感

别名和识别编码

Chemical Name	2-Chloronitrobenzene
MDL Number	MFCD00007061
CAS Number	88-73-3
Synonym	1-CHLORO-2-NI 1-Chlor-2-nitrobenzen 1-Chlor-2-nitrobenzol 1-Chloro-2-nitrobenzene 1-Chloro-2-nitrobenzene; 2-Chloro-1-nitrobenzene; o-Chloronitrobenzene; 2-CNB 1-NITRO-2-CHLORINE BENZENE 1-Nitro-2-chlorbenzol 1-Nitro-2-chlorobenzene 1-chloro-2-nitro- 1-chloro-2-nitro-benzene 1-chloro-2-nitroaniline 1-chloro-2-nitrobenzene 1-氯-2-硝基苯 1-氯-2-硝基苯/邻硝基氯苯 2-CHLORONITROBENZENE 2-Chlornitrobenzol 2-Chloro-1-nitrobenzene 2-Chloro-nitrobenzene 2-Chloronitrobenzene 2-Chluoronitrobenzene 2-NITROCHLOROBENZENE 2-Nitrochlorobenzene 2-chloronitrobenezene 2-chloronitrobenzene 2-cnb 2-氯硝基苯 2-硝基氯化苯 2-硝基氯苯 o-Chlornitrobenzol o-Chloronitro benzene o-Chloronitrobenz o-Nitrochlorbenzol o-chloronitrobenzene Chloro-o-nitrobenzen Chloro-o-nitrobenzene Nitrochlorobenzene, o- Nitrochlorobenzene, ortho O-NITROCHLOROBENZENE ONCB ORTHO NITROCHLOROBENZENE Ortho Nitrochlorobenzene [ONCB] benzene, 1-chloro-2-nitro- benzene,1-chloro-2-nitro- chloro-1nitro-2benzene o-Chloronitrobenzene o-Nitrochlorobenzene o-nitrochlorobenzene,[liquid] {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {ALD}
Beilstein Registry Number	5,241
PubChem Substance ID	87565382
EC Number	201-854-9
Merck Number	2151
Reaxys-RN	509273
Chemical Name Translation	2-硝基氯苯
Wiswesser Line Notation	WNR BG
LabNetwork Molecule ID	LN00226683

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产品应用

重要的有机合成中间体，主要用于制造邻硝基苯酚、邻氯苯胺、邻氨基苯甲（乙）醚、邻硝基苯胺以及促进剂和偶氮染料等。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H301+H311

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

RTECSCZ0875000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302
P304 IF INHALED: 如果吸入
P305 IF IN EYES: 如果进入眼睛
P308 IF exposed or concerned: 如果接触或涉及
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S20 When using do not eat or drink 使用时，不得进食，饮水；
S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S38 In case of insufficient ventilation wear suitable respiratory equipment 通风不良时，佩带适当的呼吸器；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Packing GroupII

UN Number 1578 UN 1578 6.1/PG 2 UN1578

Risk Statements

R22 Harmful if swallowed 吞咽有害
R24 Toxic in contact with skin 与皮肤接触有毒
R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
R33 Danger of cumulative effects 有累积作用的危险
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R52 Harmful to aquatic organisms 对水生生物有害
R52/53
R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用
R62 Possible risk of impaired fertility 有削弱生殖能力的危险

Hazard Codes T

Storage condition 密封保存。充氩保存

Hazard Class6.1

Warnings 危化品目录(2015)

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(2),325,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(2),325,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Gastrointestinal - tumors
   Endocrine - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 2(2),325,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   7,609,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB214-270

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 268 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB214-270

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,92,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 205 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 116,217,1983

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 4500 ppb/6H
SEX/DURATION            : male 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NIH-93-3382

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 18 ppm/6H
SEX/DURATION            : male 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NIH-93-3382

Restrict 危险品

其他信息

能溶于醇、醚和苯，不溶于水。中
方法一:由氯苯经混酸硝化，得到混合硝基氯苯。三种异构体的含量大体是：对硝基氯苯占65%，邻硝基氯苯占30%，间硝基氯苯占1%。工艺过程如下：先将配制好的混酸（含硝酸30%，硫酸56%，水14%）加入硝化锅内。维持温度40-55℃下，慢慢加入氯苯，加毕升温至80℃，搅拌反应2h。静置分层，将上层混合硝基氯苯用水洗、碱洗，水洗后静置分出，于真空加热至100℃干燥，得混合硝基氯苯。然后在结晶器内，将上述干燥后的混合硝基氯苯逐渐降温到15℃，即有大量的对硝基氯苯集于管壁，经加热熔化，收入贮槽，真空精馏，除去氯苯后即得对硝基氯苯。从结晶器下部放出的母液内含对硝基氯苯约35%，邻硝基氯苯64%及少量间硝基氯苯，供进一步分离。将此物精馏分出的粗邻硝基氯苯，再于结晶器内，采用降低结晶器内温度到15℃使之结晶的办法，即得成品。原料消耗定额：对硝基氯苯、氯苯1150kg/t、硝酸672kg/t、硫酸（92.5%）632kg/t。
急性毒性:口服- 大鼠 LD50: 268 毫克/ 公斤; 口服- 小鼠 LD50: 135 毫克/ 公斤
Sigma Aldrich:88-73-3(si
用途三:邻硝基氯苯是重要的有机合成中间体，可衍生多种中间体。在染料工业中用于制黄色基GC，橙色基GR等；在助剂方面用于制造橡胶促进剂M及DM等；在香料工业中用于香草醛的合成；农药工业用于生产托布津和甲基托布津、多菌灵；它也是苯并三氮唑类紫外线吸收剂的原料。也是医药的重要中间体。
Alfa Aesar:1-
{Chemica
图谱信息:邻氯硝基苯(88-73-3)Raman光谱邻氯硝基苯(88-73-3)核磁图( 1 HNMR) 邻氯硝基苯(88-73-3)质谱(M
职业标准:TWA 1 毫克/ 立方米; STEL 2 毫克/ 立方米
Acros Organics:1-氯-2-硝基苯 1-Chloro-2-nitrobenzene, 99+%(88-73-3)
用途四:重要的有机合成中间体，主要用于制造邻硝基苯酚、邻氯苯胺、邻氨基苯甲（乙）醚、邻硝基苯胺以及促进剂和偶氮染料等。
邻氯硝基苯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 800345
常规方法:参见“对硝基氯苯”。
用途二:是农药(如多菌灵)、染料、医药的重要中间体，也可作橡胶促进剂M的原料
用途五:重要的
MOL 文件:88-73-3.mol
防护措施:参见“对硝基氯苯”。
图谱信
下游产品:1,2-苯二胺 --> 邻甲基苯胺 --> 4-硝基氯苯 --> 邻甲氧基苯胺 --> 2-巯基苯并噻唑 --> 2-氯苯胺 --> 愈创木酚 --> 2,4-二硝基氯苯 --> 2-氨基苯酚 --> 2-硝基苯胺 --> 2-硝基苯酚 --> 颜料黄 12 --> 2-氨基苯硫醇 --> 多潘立酮 --> 2-氨基-4-磺酰胺基苯酚 --> 2-氟苯胺 --> 2-氨基苯磺酸 --> N-甲基邻苯二胺盐酸盐 --> 2-巯基苯并咪唑 --> 邻氨基苯乙醚 --> 2-氯-6-硝基甲苯 --> 2-(4-甲基苯基)苯并噻唑 --> N-甲基-2-硝基苯胺 --> 1-氟-2-硝基苯 --> 分散黄M-FL --> 双(2-硝基苯基)二硫化物 --> 敌菌灵 --> 2-硝基苯甲醚 --> 2-氟苯酚 --> 4-氯
{C
海关编码:29049085
Alfa Aesar:1-氯-2-硝基苯,99% 1-Chloro-2-nitrobenzene, 99%(88-73-3)
上游原料:氢氧化钠 --> 盐酸 --> 硫酸 --> 硝酸 --> 二甲基亚砜 --> 氯化亚铜 --> 氯苯 --> 4-硝基氯苯 --> 2-硝基苯胺 --> 3-硝基氯苯 --> 亚硝酸钾
能溶于醇、醚和苯，不溶于水。中等毒，半数致死量(大鼠，经口)288mg/kg。有刺激性。

2-Chloronitrobenzene 2-硝基氯苯

CAS 88-73-3 MFCD00007061

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