2-Mesitylenesulfonyl chloride 2,4,6-三甲基苯磺酰氯
CAS 773-64-8 MFCD00007434
化学结构图
SMILES: Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1
化学属性
| Mol. Formula | C9H11ClO2S |
|---|---|
| Mol. Weight | 218.70 |
| Density | 1.422 |
| Melting Point | 55-57°C |
| Flash Point | >110°(230°F) |
| TSCA | No |
| Boiling Point | 303.1°C at 760 mmHg |
| Solubility | 不溶 |
| Stability | 对湿度敏感 |
别名和识别编码
| Chemical Name | 2-Mesitylenesulfonyl chloride |
|---|---|
| Synonym | 2-Mesitylenesulfonyl chloride {LY} 2-Mesitylenesulfonyl chloride {} {LY} 2-Mesitylenesulfonyl chloride {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {} {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Mesitylenesulfonyl chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Mesitylenesulfonyl |
| CAS Number | 773-64-8 |
| EC Number | 212-257-8 |
| Beilstein Registry Number | 1107601 |
| MDL Number | MFCD00007434 |
| PubChem Substance ID | 87572184 |
| Reaxys-RN | 1107601 |
| Chemical Name Translation | 2,4,6-三甲基苯磺酰氯 |
| Wiswesser Line Notation | WSGR B1 D1 F1 |
| InChIKey | PVJZBZSCGJAWNG-UHFFFAOYSA-N |
| LabNetwork Molecule ID | LN00194080 |
| InChI | InChI=1S/C9H11ClO2S/c1-6-4-7(2)9(8(3)5-6)13(10,11)12/h4-5H,1-3H3 |
| Canonical SMILES | CC1=C(S(=O)(Cl)=O)C(C)=CC(C)=C1 |
信息真实价格透明
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
- {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfonyl Halides, Sulfur Compounds
产品应用
- 多核苷酸合成中的偶联剂
相关文献及参考
- The indole nitrogen, e.g. in tryptophan residues, may also be protected as the Mts amide, stable to dilute alkali, hydrazine hydrate, TFA, 4N HCl in dioxane, or HBr in AcOH, but cleaved by MsOH, or TfOH in TFA: Chem. Pharm. Bull., 32, 2660 (1984). See Appendix 6.
- Reagent for protection of the guanidino function of arginine residues as mesitylenesulfonyl (Mts) derivatives in peptide synthesis: J. Chem. Soc., Chem. Commun., 482 (1978); Chem. Pharm. Bull., 26, 3752 (1978); Int. J. Pept. Prot. Res., 14, 169 (1979). Deprotection can be effected with triflic acid in TFA in the presence of thioanisole as a
- Selective reagent for sulfonylation of carbohydrates: J. Chem. Soc., Perkin 1, 1373 (1974).
- Reagent for protection of the guanidino function of arginine residues as mesitylenesulfonyl (Mts) derivatives in peptide synthesis: J. Chem. Soc., Chem. Commun., 482 (1978); Chem. Pharm. Bull., 26, 3752 (1978); Int. J. Pept. Prot. Res., 14, 169 (1979). Deprotection can be effected with triflic acid in TFA in the presence of thioanisole as a cation scavenger: J. Chem. Soc., Chem. Commun., 1063 (1980).
- For reviews of the use of hindered sulfonyl chlorides as condensing agents for the formation of the phosphate link of oligonucleotides, see: Angew. Chem. Int. Ed., 11, 451 (1972); Synthesis, 222 (1975); Chem. Rev., 77, 183 (1977). For reviews of oligonucleotide synthesis by the phosphotriester method, see: Heterocycles, 7, 1197 (1977); Tetrahedron, 34, 3143 (1978). Compare 2,4,6-Triisopropylbenzenesulfonyl chloride, A11458.
- Short: III/20b
- Short: EINECS
安全信息
Signal word
Danger
GHS Symbol
WGK Germany3
Safety Statements
- S22 Do not breathe dust 不要吸入粉尘；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
- R29 Contact with water liberates toxic gas. 遇水释放出有毒气体
- R34 Causes burns 会导致灼伤
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
- P234 Keep only in original container. 只保留在原来的容器中。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331
- P301+P330+P331+P310
- P303+P361+P353+P310+P363
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
- P405 Store locked up. 上锁保管。
- P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSDB8930000
Packing GroupII
UN Number
3261
UN 3261 8/PG 2
UN3096
Storage condition
2-8°C, sealed storage, away from moisture
{LY} 2-8°C, sealed storage, away from moisture
Moisture Sensitive
Store at RT.
Store at room temperature
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Hazard Codes
8
C
Hazard Class8
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02913
其他信息
- MOL 文件:773-64-8.mol
- 上游原料:均三甲苯
- 用途一:氨基酸分子内酯化和环合试剂，用于其他有机合成。
- Sigma Aldrich:3453-83-6(sigmaaldrich)
- MOL 文件:3453-83-6.mol
- Acros Organics:2,4,6-三甲基苯磺酰氯 2-Mesitylenesulfonyl chloride, 99%(773-64-8)
- MSDS 信息:Mesitylenesulfonyl chloride(773-64-8).msds
- TCI Shanghai:2,4,6-三甲基苯磺酰氯 2-Mesitylenesulfonyl Chloride,>;99.0%(T)(773-64-8)
- 海关编码:29309070
- 图谱信息:2-甲基磺酰氯(3453-83-6)质谱(MS) 2-甲基磺酰氯(3453-83-6)核磁图( 1 HNMR) 2-甲基磺酰氯(3453-83-6)核磁图( 13 CNMR) 2-甲基磺酰氯(3453-83-6)红外图谱(IR2) 2-甲基磺酰氯(3453-83-6)红外图谱(IR1)
- Alfa Aesar:荚-2-磺酰氯,98+% Mesitylene-2-sulfonyl chloride, 99%(773-64-8)
- Sigma Aldrich:773-64-8(sigmaaldrich)
- 图谱信息:2,4,6-三甲基苯磺酰氯(773-64-8)红外图谱(IR1) 2,4,6-三甲基苯磺酰氯(773-64-8)红外图谱(IR2) 2,4,6-三甲基苯磺酰氯(773-64-8)质谱(MS) 2,4,6-三甲基苯磺酰氯(773-64-8)核磁图( 1 HNMR) 2,4,6-三甲基苯磺酰氯(773-64-8)红外图谱(IR3)
- 下游产品:2-[(氨基氧基)磺酰]-1,3,5-三甲基苯 --> 4-甲基-2-(1H-吡唑-2-基)喹啉
- Hazard Note:Corrosive
- F:10-21
- 方法一:在搅拌下将30g（0.25mol）均三甲苯在0.5h内滴加到冷至0℃的80g（0.69mol）氯磺酸中，继续搅拌0.5h。将反应混合物倾入碎冰中，得50g2,4,6-三甲基苯磺酰氯，收率92%。
- TCI Shanghai:2,4,6-三甲苯基磺酸 Mesitylenesulfonic Acid Dihydrate,>;78.0%(T)(3453-83-6)
- 敏感性:Moisture Sensitive
- 2-甲基磺酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0068 均三甲苯磺酸二水合物 Mesitylenesulfonic Acid Dihydrate 500G 5570元 2014/06/02 M0068 均三甲苯磺酸二水合物 Mesitylenesulfonic Acid Dihydrate 25G 665元
- 2,4,6-三甲基苯磺酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0071 2-磺酰氯基均三甲苯 2-Mesitylenesulfonyl Chloride 25G 569元 2014/06/02 M0071 2-磺酰氯基均三甲苯 2-Mesitylenesulfonyl Chloride 500G 5280元 2010/06/21 125591000 2,4,6-三甲基苯磺酰氯 2-Mesitylenesulfonyl chloride 99% 100 GR 1743元
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