o-Anisidine 邻甲氧基苯胺

CAS 90-04-0 MFCD00007688

化学结构图

90-04-0
SMILES: COC1CCCCC1N

化学属性

Mol. FormulaC7H9NO
Mol. Weight123
Refractive index1.5730 to 1.5770
Boiling Point225
Density1.092
Melting Point3-6
Flash Point111°C(lit.)
TSCAYes
SolubilitySolubility in water: 13 g/L (20°C) Solubility in other solvents: Soluble in dilute mineral acid Miscible with alcohol and ether Soluble in acetone and benzene
Stability对光敏感

别名和识别编码

Chemical Nameo-Anisidine
CAS Number90-04-0
Alfabeta NameANISIDINE O-
MDL NumberMFCD00007688
Synonym 2-METHOXYANILINE 邻茴香胺 o-Aminoanisole o-Methoxyaniline 2-甲氧基苯胺/邻茴香胺 2-氨基苯甲醚 2-Methoxybenzenamine o-Aminomethoxybenzene o-Methoxyphenylamine 2-methoxy-benzenamine 2-甲氧基苯胺 鄰-甲氧苯胺 2-AMINOANISOLE 1-Amino-2-methoxybenzene O-METHOXYANILINE 2-氨基苯甲醚 2-甲氧基苯胺 o-Anisidine O-AMINOANISOLE 原亚锑酸盐 A-ESTER VINYL SULPHONE 1-AMINO-2-METHOXYBENZENE 1-Amino-2-methoxybenzene; 2-Aminoanisole; 2-Methoxyaniline 2-methoxy-aniline 2-Methoxyaminobenzol 邻甲氧基苯胺 O-ANISIDINE Benzenamine, 2-methoxy- 2-Aminoanisole 2-Methoxyaniline
PubChem Substance ID7000
EC Number201-963-1
Beilstein Registry Number386210
Reaxys-RN386210
Merck Number667
Chemical Name Translation邻甲氧基苯胺
LabNetwork Molecule IDLN00173828
InChIInChI=1S/C7H9NO/c1-9-7-5-3-2-4-6(7)8/h2-5H,8H2,1H3
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分类

  • {SNA} A,
  • A, A-B, AM to AQ, Alpha Sort, Alphabetic, Amines, Analytical Standards, Analytical/Chromatography, Aromatics, Aryl Amines MAK III, Category 2, Chemical Class, Chromatography, Environmental Standards, Food & Beverage Standards, Food Dyes, Food Residue Analysis, Method Specific, Oeko-Tex Standard 100, Volatiles/ Semivolatiles
  • {SNA} A-B, A-C, Additional Standards, All alphabetical sorted, Alpha Sort, Amines, Analytical Standards,
  • {SNA} Amines,

产品应用

  • 显微微晶分析检验氰化物。络合指示剂滴定汞。有机合成。

相关文献及参考

  • Short: II/27B
  • Short: II/5
  • Beilstein:13(3)754

安全信息

Warnings 危化品目录(2015) IRRITANT
GHS Symbol
WGK Germany3
Hazard statements
  • H301+H311+H331
  • H350 May cause cancer 可能致癌
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes T T,Xi
RTECSBZ5410000
Precautionary statements
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P308+P313
  • P332+P313
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P302+P350
  • P337+P313
  • P403+P233
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P301+P310+P330
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P304+P340+P311
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P305+P351+P338+P337+P313
  • P308+P311
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
Signal word
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R45 May cause cancer 可能致癌
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
UN Number
Storage condition Refrigerator 储存温度2-8°C,充氩保存 储存温度2-8℃ 密封避光保存。 Light Sensitive 0-10°C 0-10
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 870 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Blood - normocytic anemia
   Blood - other changes
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,63,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 422 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Blood - normocytic anemia
   Blood - other changes
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,63,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
   Instituta.  (Leningrad, Russia) V.1-145, 1949-82.  Discontinued.

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 690 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 412,155,1998

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1200 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 333 ug/plate
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,63,1982

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1250 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/pag

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 38 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1

Restrict 危险品

其他信息

  • 职业标准:TW
  • {
  • 毒性分级:中毒
  • {Chemical
  • MSDS 信息:邻甲氧基苯胺(90-04-0).msds
  • MOL 文件:90-04-0.mol
  • Sigma Aldrich:90-04-0(si
  • Acros Organics:邻氨基苯甲醚 o-Anisidine, 99+%(90-04-0)
  • 检测方法:GC,NMR
  • {Chemicalb
  • 露置空气中变成棕色。能随水蒸气挥发。溶于稀
  • 敏感性:Light Sensitive
  • 用途四:显微微晶分析检验氰化物。络合指示剂滴定汞。有机合成。
  • Alfa Aesar:邻茴香胺,99% o-Anisidine, 99%(90-04-0)
  • 方法一:由邻硝基苯甲醚还原而得,邻硝基苯甲醚可由邻硝基氯甲苯氧基化得到[91-23-6],还原剂可采用硫化钠或铁粉。另外,也可由邻硝基苯酚经甲基化、还原来制取邻甲氧基苯胺。原料消耗定额:邻硝基氯苯1301kg/t、甲醇(98%)395kg/t、硫化钠(60%)1128kg/t、烧碱(96%)457kg/t。
  • 能随水蒸气挥发。溶于稀矿酸、乙醇和乙醚、丙酮、苯,微溶于水。有毒。有致癌可能性。有刺激
  • 用途三:可用于制取偶氮染料、冰染染料及色酚AS-OL等染料以及愈创木酚、安痢平等医药。还可制取香兰素等。
  • 职业标准:TWA 0
  • 下游产品:香兰素 --> 愈创木酚 --> 4,8-二羟基喹啉-2-甲酸 --> 萘酚AS-BI磷酸盐 --> 5-溴-8-甲氧基-2-甲基喹啉 --> 2-甲氧基-4-硝基苯胺 --> 2-甲氧基苯硫酚 --> 耐晒猩红RC --> 邻甲氧基-N-乙酰乙酰苯胺 --> 2-乙酰氨基苯甲醚 --> 1-(2-甲氧苯基)哌嗪 --> 1-(2-甲氧基苯基)哌嗪氢溴酸盐 --> 3,4-二氢-8-羟基-4-羰基喹啉-3-羧酸 --> 分散橙 29 --> 2'-甲基乙酰乙酰苯胺 --> N-(4-氨基-2-甲氧基苯基)乙酰胺 --> 3-羟基-N-(2-甲氧基苯基)-2-萘甲酰胺 --> 3,8-二甲基-1,10-菲罗啉 --> 4-羟基-8-甲氧基喹啉-3-羧酸 --> 4-氯-2-氨基苯甲醚 --> 2-氟苯甲醚 --> 天狼黄 --> 直接耐晒黄 G --> 红色基 ITR --> 2-甲氧基苯基异氰酸酯 --> 4-羟基-8-甲氧基喹啉-3-羧酸乙酯 --> 2-甲氧基-4-硝基乙酰苯胺 --> 活性黄KE-4RN --> 耐晒红B盐 --> 直接铜盐灰 GRL --> 2-甲氧基氰苯 --> 桃红色基ITR --> 色酚 AS-CA
  • 用途一:用作染料、香料及医药中间体
  • 用途二:用作测定汞的络合指示剂,偶氮染料中间体及杀菌剂
  • 上游原料:氢氧化钠 --> 甲醇 --> 铁粉 --> 硫化钠 --> 邻氯硝基苯 --> 2-硝基苯酚
  • 图谱信息:邻甲氧基苯胺(90-04-0)质谱(MS) 邻甲氧基苯胺(90-04-0)红外图谱(IR2) 邻甲氧基苯胺(90-04-0)核磁图( 1 HNMR) 邻甲氧基苯胺(90-04-0)核磁图( 13 CNMR) 邻甲氧基苯胺(90-04-0)红外图谱(IR1)
  • 急性毒性:口服-大鼠 LD50: 2000 毫克/公斤; 口服-小鼠 LD50: 1400 毫克/公斤
  • 外观性质:浅黄色油状液体。
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • TCI Shanghai:2-甲氧基苯胺 o-Anisidine,>;98.0%(GC)(T)(90-04-0)
  • 邻甲氧基苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80080580 邻甲氧基苯胺 50ml 38元 2011/08/23 80080526 邻甲氧基苯胺 100ml 72元 2011/04/16 A0486 邻茴香胺 o-Anisidine 500ML 632元

系列性分类