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• {Chemicalbook} 农药中间体: 杀虫剂中间体: 有机磷类杀虫剂

相关文献及参考

• Aldrich MSDS 1 , 1795:C / Corp MSDS 1 (2), 3494:A / FT-IR 1 (1), 910:A / FT-IR 2 (1), 1544:D / FT-NMR 1 (1), 1465:C / IR-Spectra (2), 486:A / IR-Spectra (3), 548:B / NMR-Reference 2 (2), 862:B / RegBook 1 (1), 1093:A / Sax 6 , 2674 / Sigma FT-IR 1 (2), 958:B / Structure Index 1 , 168:C:9 / Vapor Phase 3 , 838:B
• Beil. 1 ,IV,1256
• Fieser 1 ,1233 / Fieser 2 ,439 / Fieser 3 ,315 / Fieser 4 ,541 / Fieser 5 ,717 / Fieser 7 ,393 / Fieser 9 ,490 / Fieser 11 ,570 / Fieser 12 ,536
• Short: II/2 Title: Magnetic Properties of Coordination and Organometallic Transition Metal Compounds Author: König, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/2 Year: 1966 ISBN: 3-540-03593-1 ISBN: 978-3-540-03593-0 Internet Resource: DOI:10.1007/b19948 RefComment: 170 figs., XII, 578 pages. Hardcover Abstract: The data compiled refer to susceptibility measurements (susceptibility, Curie-constants, magnetic moments, transition temperatures) and ESR-measurements (g-factors and other parameters of the applied spin Hamiltonian). In volume II/2 the literature from 1899 up to 1964 has been considered. Volume II/8 supplements volume II/2, taking into account the data on magnetic susceptibilities and ESR parameters published in the p eriod 1964 to 1968. The following subvolumes II/10,II/11, II/12 supplement data up to 1974.
• Short: II/25C Title: Structure Data Of Free Polyatomic Molecules: Molecules containing Three or Four Carbon Atoms Author: Graner, G.; Hirota, E.; Iijima, T.; Kuchitsu, K.; Ramsay, D.A.; Vogt, J.; Vogt, N. Editor: Kuchitsu, K. Source: Landolt-Börnstein, New Series Volume: II/25C Year: 2001 Keyword: Free Polyatomic Molecules; Carbon Atoms; Molecules ISBN: 3-540-66774-1 ISBN: 978-3-540-66774-2 Internet Resource: DOI:10.1007/b71431 RefComment: VIII, 481 pages. Hardcover Abstract: This volume c

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ALBRW* Albright & Wilson Inc.  (P.O. Box 26229, Richmond, VA 23260-6229)
   Volume(issue)/page/year: #OPB-3,1984

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   34,286,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   34,286,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ENVRAL Environmental Research.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1967-  Volume(issue)/page/year: 9,1,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1640 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Specific Developmental Abnormalities - homeostasis
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   72,119,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1640 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   72,119,1984

其他信息

• 方法一:亚磷酸三甲酯的合成主要分直接法和间接法两大类。 (1)直接酯化法 以有机碱为缚酸剂，由三氯化磷和甲醇在惰性溶剂中进行反应制得。根据缚酸剂的不同，又分为氨法、叔胺一氨法、氨基甲酸铵法等，目前以叔胺一氨法为常用的方法。 PCl 3 +CH 3 OH+C 6 H 5 N(CH 3 ) 2 [二甲苯]→(CH 3 O) 3 P+C 6 H 5 N(CH 3 ) 2 ·HCl C 6 H 5 N(CH 3 ) 2 ·HCl+NH 3 →C 6 H 5 N(CH 3 ) 2 +NH 4 Cl 以叔胺(如N，N-二甲基苯胺)为缚酸剂，将甲醇和溶剂邻二氯苯按比例混配，搅拌并冷却至5℃以下，滴加三氯化磷(溶于二甲苯中，含量为33％左右)，控制反应温度不超过25℃，并用氨控制pH=6。滴完后用氨中和至pH=8～9，然后真空蒸馏，最终得到亚磷酸三甲酯产品，含量为95%，收率85%(以三氯化磷计)。生成的叔胺盐酸盐用氨解析出，得到副产物氯化铵，经处理可作农用肥料。 国内对亚磷酸三甲酯合成工艺进行了许多研究和改进，如安徽省化工研究院开发的新工艺以三乙胺为缚酸剂，液碱为中和剂，在溶剂中直接连续合成。整个工艺(包括合成、水洗、分层、脱水干燥、精馏等工序)均实现连续化，降低了劳动强度，提高了产品质量，具有明显的社会效益和经济效益。 (2)间接法(即酯交换法) 先由三氯化磷与苯酚进行反应合成亚磷酸三苯酯，再在碱性催化剂存在下与甲醇进行酯交换，得到亚磷酸三甲酯。 PCl 3 +3C 6 H 5 OH(过量)→(C
• 上游原料:甲醇钠 --> N,N-二甲基苯胺 --> 邻二氯苯 --> 亚磷酸三苯酯
• 爆炸物危险特性:与空气混合可爆炸
• 储运特性:包装完整、轻装轻放; 库房通风、远离明火、高温、与氧化剂分开存放; 防潮
• 下游产品:三唑酮 --> 草甘膦 --> 敌敌畏 --> 杀虫畏 --> 6-溴异喹啉 --> 6-甲基异喹啉 --> 亚磷酸
• 用途一:亚磷酸三甲酯是一种重要的有机磷中间体，可用于合成有机磷杀虫剂敌敌畏、久效磷、磷胺、速灭磷、百治磷、杀虫畏等，也可合成其他中间体如O，O-二甲基磷酰氯、O，O-二甲基硫(醇)代磷酸盐等，此外，还用于其他有机合成、化纤阻燃、离子薄膜、医药工业等方面。
• 常规方法:铁桶或塑料桶包装。贮于阴凉干燥仓库。贮存时需用氮气保护，以防自动氧化生成磷酸三甲酯。按有毒化学品规定贮运。
• 毒性分级:中毒
• F:10-
• 防护措施:无色透明液体，有刺激性臭味。易燃。相对密度1.0520（25/5℃）。流动点
• 方法二:1.酯交换法先将苯酚与三氯化磷反应，生成亚磷酸三苯酯，然后在甲醇钠存在下与甲醇进行酯交换生成亚磷酸三甲酯。粗酯经蒸馏脱除残余甲醇及苯酚，成为成品。原料消耗定额：苯酚（凝固点≥40℃）237kg/t、三氯化磷（96%）1396kg/t、甲醇（98%）855kg/t、甲醇钠（27-31%）83kg/t。2.叔胺-氨法是以二甲苯为溶剂，甲醇和三氯化磷在N，N-二甲基苯胺存在下进行酯化反应，生成亚磷酸三甲酯。再经水洗、脱水、精馏得成品。原料消耗定额：甲醇（95%）1025kg/t、
• 方法二:1.酯交换法先将苯酚与三氯化磷反应，生成亚磷酸三苯酯，然后在甲醇钠存在下与甲醇进行酯交换生成亚磷酸三甲酯。粗酯经蒸馏脱除残余甲醇及苯酚，成为成品。原料消耗定额：苯酚（凝固点≥40℃）237kg/t、三氯化磷（96%）1396kg/
• 图谱信息:三甲氧基磷(121-45-9)红外图谱(IR1) 三甲氧基磷(121-45-9)核磁图( 13 CNMR) 三甲氧基磷(121-45-9)质谱(MS) 三
• 灭火剂:泡沫、二氧化碳、砂土
• 蒸气压:17 mm Hg ( 20 °C)
• MOL 文件:121-45-9.mol
• 可燃性危险特性:遇明火、高温、强氧化剂可燃; 受热分解有毒氧化磷气体
• Alfa Aesar:亚磷酸三甲酯,99% Trimethyl phosphite, 99%(121-45-9)
• Sigma Aldrich:121-45-9(sigmaaldrich)