• 原料直供
• 试剂商城
• 直接询价

分类

• Pharmaceuticals
• Intermediates & Fine Chemicals
• {SNA} Building Blocks, C10 to C11, Carbonyl Compounds, Chemical Synthesis, Esters, Organic Building Blocks

产品应用

• Intermediate in the production of Flumequine

相关文献及参考

• Sato, M., et al.: J. Med. Chem., 52, 4869 (2009),
• Has been used for the protection of the amino group of ɑ-amino acids, allowing clean esterification by O-alkylation. The protecting group can be removed using bromine in chloroform: Synthesis, 544 (1989):
• Stable equivalent of the ɑ-formylmalonate, valuable synthetic building block, particularly in heterocyclic syntheses. Review: Adv. Het. Chem., 54, (1992).
• For N-protection of aminoglycosides prior to O-acetylation, see: J. Carbohydr. Chem., 14, 1133 (1995). Chlorine in chloroform at 0oC was used for deprotection.
• Can be converted to the unstable diethyl methylenemalonate by catalytic reduction and elimination of ethanol on distillation, see: Org. Synth. Coll., 4, 298 (1963).

安全信息

GHS Symbol

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NDRC** National Defense Research Committee, Office of Scientific Research
   and Development, Progress Report.  Volume(issue)/page/year: 30101,11,1945

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2227 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 60,1810,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 925 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - other changes
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 1,37,1990

其他信息

• 用途一:一种分子中含有多种活性基团的重要有机原料，能与多种物质进行缩聚和环化缩合，现主要用于合成氟哌酸
• Acros Organics:乙氧基亚甲基丙二酸二乙酯 Diethyl ethoxymethylenemalonate, 99+%(87-13-8)
• 方法一:将原甲酸三乙酯、醋酐、丙二酸二乙酯和无水氧化锌的混合物搅拌加热，在102-115℃保温2.5h，在115-127℃保温7h，再补加部分醋酐和原甲酸三乙酯，继续升温至127-145℃保温2h，145-155℃保温2h。然后将反应物冷至室温，过滤。滤液减压蒸馏，收集108-110℃（33Pa）馏分，得成品，收率50-60%。
• 乙氧基甲叉丙二酸二乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 E0255 乙氧基亚甲基丙二酸二乙酯 Diethyl Ethoxymethylenemalonate 25ML 102元 2014/06/02 E0255 乙氧基亚甲基丙二酸二乙酯 Diethyl Ethoxymethylenemalonate 500ML 650元 2010/06/21 114345000 乙氧基甲叉丙二酸二乙酯 Diethyl ethoxymethylenemalonate 99+% 500 GR 904元
• 海关编码:29189090
• Intermediate for the production of Flumequine.
• Alfa Aesar:乙氧亚甲基丙二酸二乙酯,98+% Diethyl ethoxymethylenemalonate, 98+%(87-13-8)
• 上游原料:原甲酸三乙酯 --> 丙二酸二乙酯
• TCI Shanghai:乙氧基亚甲基丙二酸二乙酯 Diethyl Ethoxymethylenemalonate,>;98.0%(GC)(87-13-8)
• 图谱信息:乙氧基甲叉丙二酸二乙酯(87-13-8)质谱(MS) 乙氧基甲叉丙二酸二乙酯(87-13-8)红外图谱(IR1) 乙氧基甲叉丙二酸二乙酯(87-13-8)核磁图( 1 HNMR)
• MSDS 信息:Diethyl ethoxymethylenemalonate(87-13-8).msds
• Sigma Aldrich:87-13-8(sigmaaldrich)
• 下游产品:氟哌酸 --> 甲草胺 --> 洛美沙星 --> 乳清酸 --> 2-三氟甲基-4-氯嘧啶-5-羧酸乙酯 --> 2-甲基巯基-4-氨基嘧啶-5-甲酸乙酯 --> 4-氯-2-甲硫基嘧啶-5-羧酸乙酯 --> 5,6,7,8-四氢吡啶并[4,3-D]嘧啶-4(3H)-酮 --> 左氧氟沙星 --> 7-三氟甲基-4-硫醇喹啉 --> 1,4-二氢-2-甲巯基-4-氧代-5-嘧啶甲酸乙酯 --> 7-溴-3,4-二氢-4-羰基喹啉-3-羧酸 --> 7-(三氯甲基)-4-羟基喹啉 --> 氟罗沙星 --> 2-甲基-4-羟基嘧啶-5-羧酸乙酯 --> 萘啶酸 --> 2-苯基-4-羟基嘧啶-5-羧酸 --> 3,4-二氢-8-羟基-4-羰基喹啉-3-羧酸 --> 7-溴-3,4-二氢-4-羰基喹啉-3-羧酸乙酯 --> 4-羟基-8-甲氧基喹啉-3-羧酸 --> 6-氯-1,2,4-三唑并[4,3-B]哒嗪 --> 2-苯基-4-羟基嘧啶-5-羧酸乙酯 --> 癸氧喹酯 --> 4-羟基-8-甲氧基喹啉-3-羧酸乙酯
• MOL 文件:87-13-8.mol
• 用途二:有机合成原料，用于医药、染料等产品制造。