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• 试剂商城
• 直接询价

分类

• {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Phosphonates/Phosphinates, Phosphorus Compounds

产品应用

• 常用作肽合成的偶联剂、苯酚的磷酸化试剂；还可用于羧酸荧光衍生化的活化剂，可通过 HPLC 分离活化剂。

相关文献及参考

• Strecker reaction with aldehydes or ketones in the presence of amines or ammonia gives goodyields ofɑ-amino nitriles: Tetrahedron Lett., 4663 (1979). Pre-formed enamines give the same products: Synthesis, 716 (1979).
• Phosphorylating agent for phenols: Synth. Commun., 27, 3035 (1997).
• Activates carboxylic acids towards nucleophiles:
• Beil. 3 ,IV,260
• Thiol esters can be formed under similar conditions: J. Org. Chem., 39, 3302 (1974).
• Beilstein: 3,IV,260
• Promotes the formation of amides and esters from amines or alcohols in the presence of, e.g. triethylamine : Tetrahedron, 32, 2211 (1976). The reaction is applicable to peptide synthesis, since little racemization has been observed: J. Am. Chem. Soc., 97, 7174 (1975). The extent of racemization in comparison with other methods has been studied: Chem. Pharm. Bull., 30, 3147 (1982). See Appendix 6. With 2 equivalents of reagent in the absence of a nucleophile, an intermediate 1-(1,1-dicyano)phosphate is formed, leading, on treatment with acid, to the homologated ɑ-hydroxy acid: Tetrahedron Lett., 39, 9209 (1998).
• Can also be used to activate carboxylic acids for the C-acylation of active methylene compounds: J. Org. Chem., 43, 3631 (1978). In the presence of Lewis acids, active methylene compounds such as dimethyl malonate react with the cyanophosphonate itself. The product can be converted to a uracil derivative by reaction with phenyl isocyanate: Chem. Pharm. Bull., 42, 1919 (1994):

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JCSOA9 Journal of the Chemical Society.  (London, UK)  1926-65.  For
   publisher information, see JCPRB4.  Volume(issue)/page/year: -,699,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JCSOA9 Journal of the Chemical Society.  (London, UK)  1926-65.  For
   publisher information, see JCPRB4.  Volume(issue)/page/year: -,699,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PAREAQ Pharmacological Reviews.  (Williams & Wilkins, 428 E. Preston St.,
   Baltimore, MD 21202) V.1-    1949-  Volume(issue)/page/year: 11,636,1959

其他信息

• 图谱信息:氰基磷酸二乙酯(2942-58-7)质谱(MS) 氰基磷酸二乙酯(2942-58-7)红外图谱(IR1)
• 下游产品:膦甲酸钠
• 用途二:多肽缩合剂[1]，酚羟基磷酸化试剂[2]，含羧基化合物进行HPLC分析时制备荧光衍生物时的活化剂。
• Acros Organics:氰基磷酸二乙酯 Diethyl cyanophosphonate, 93%(2942-58-7)
• Sigma Aldrich:2942-58-7(sigmaaldrich)
• Hazard Note:Irritant
• 用途一:有机合成中间体。
• 上游原料:溴氰 --> 磷酸二乙酯
• 氰基磷酸二乙酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 C1242 氰基磷酸二乙酯 Diethyl Cyanophosphonate 25G 1350元 2014/06/02 C1242 氰基磷酸二乙酯 Diethyl Cyanophosphonate 5G 404元 2010/06/21 224290050 氰基磷酸二乙酯 Diethyl cyanophosphonate 93% 5 GR 450元
• TCI Shanghai:氰基磷酸二乙酯 Diethyl Cyanophosphonate,>;93.0%(GC)(2942-58-7)
• F:10-13-21
• 方法一:将过量的溴化氰滴入磷酸二乙酯中，反应液逐渐变热。反应毕，减压蒸馏，收集104-105℃（2.53kPa）馏分，得氰基磷酸二乙酯。收率65%。
• Alfa Aesar:腈基磷酸二乙酯,tech.90% Diethyl cyanophosphonate, tech. 90%(2942-58-7)
• MSDS 信息:DEPC(2942-58-7).msds
• 敏感性:Moisture Sensitive
• MOL 文件:2942-58-7.mol