Potassium Bis(Trimethylsilyl)Amide 双(三甲基硅烷基)氨基钾
CAS 40949-94-8 MFCD00010330
化学结构图
SMILES: C[Si](C)(C)N([K])[Si](C)(C)C
化学属性
| Mol. Formula | [(CH3)3Si]2NK |
|---|---|
| Mol. Weight | 199.48 |
| Density | 0.798 g/mL at 25 °C |
| Refractive index | 1.4920 |
| Flash Point | -14°(6°F) |
| TSCA | No |
| Boiling Point | 66° |
| Vapor Density | 3.2 (vs air) |
| Vapor Pressure | 54 mmHg ( 25 °C) |
| Stability | 对湿度敏感 |
| Danger-Level | 甲类 |
| pH | -:A |
| Redox | - |
别名和识别编码
| Chemical Name | Potassium Bis(Trimethylsilyl)Amide |
|---|---|
| Synonym | 六甲基二硅氮烷 钾盐 溶液 双(三甲基硅基)氨基钾, 20% W/W, 0.91M IN THF 双(三甲基硅烷基)氨基钾 溶液 Potassium hexamethyldisilazide 六甲基二硅基胺基钾 溶液 六甲基二硅基胺基钾 溶液 六甲基二硅氮烷 钾盐 溶液 |
| MDL Number | MFCD00010330 |
| PubChem Substance ID | 3251421 |
| Beilstein Registry Number | 4006754 |
| EC Number | 424-100-2 |
| CAS Number | 40949-94-8 |
| Alfabeta Name | POTASSIUMBISTRIMETHYLSILYLAMIDE () |
| Chemical Name Translation | 双(三甲基硅烷基)氨基钾 |
| Reaxys-RN | 4006754 |
| LabNetwork Molecule ID | LN00163929 |
| InChI | InChI=1S/C6H18NSi2.K/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1 |
| InChIKey | IUBQJLUDMLPAGT-UHFFFAOYSA-N |
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分类
- {SNA} 12 Principles Aligned Products, 25mL Sure/Seal Reagents, Acids & Bases, Bases, Chemical Synthesis, Greener Alternative Products, Orga
- {SNA} Acids & Bases,
- {SNA} Chemical Synthesis, Organometallic Reagents, Organosilicon, Others
- {SNA} 12 Principles Aligned Products, 25mL Sure/Seal Reagents, Acids &
产品应用
- ⑴.常温常压条件下为液体。
- ⑵.非亲核性强碱。
- ⑶.医药中间体，主要用于合成头孢抗生素的生产。
- 非亲核性强碱。
相关文献及参考
- Also used in the Wittig reaction, to give Li salt-free product distribution for selective (Z)-alkene formation: J. Org. Chem., 45, 4260 (1980). Has also been used with 18-crown-6 for selective formation of (Z)-ɑß-unsaturated esters from phosphonates: Tetrahedron Lett., 24, 4405 (1983).
- Sterically hindered strong base, compare Sodium bis(trimethylsilyl)amide, L13352 and Lithium bis(trimethylsilyl)amide, L15012. Used in the generation of K enolates, preferred to their Li or Na counterparts in some reactions, see e.g.: Tetrahedron Lett., 32, 1779 (1991); J. Am. Chem. Soc., 109, 6881 (1987); 111, 1063 (1989).
安全信息
GHS Symbol
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P403+P233
- P305+P351+P338+P310
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P330+P331+P310
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P370+P378
- P304+P340
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P301+P310
- P301+P310+P331
- P273 Avoid release to the environment. 避免释放到环境中。
- P308+P311
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H302 Harmful if swallowed 吞食有害
- H351 Suspected of causing cancer 怀疑致癌
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
- H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
- H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- R14 Reacts violently with water 遇水会猛烈反应
- R11 Highly flammable 非常易燃
- R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
- R48/20
- R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
- R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
- R34 Causes burns 会导致灼伤
- R19 May form explosive peroxides 可能生成易爆的过氧化物质
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用（指明具体的消防器材种类，如果用水增加危险，注明“禁止用水”
- S30 Never add water to this product 切勿将水加入该产品中；
- S20 When using do not eat or drink 使用时，不得进食，饮水；
- S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
- S33 Take precautionary measures against static discharges 对静电采取预防措施；
- S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
- S8 Keep container dry 保持容器干燥；
其他信息
- ⑴.储存于阴凉、干燥、通风良好的专用库房内，远离火种、热源。 ⑵.出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。 ⑶.操作时穿戴合适的防护服、手套并使用防护眼镜或者面罩。 ⑷.未经政府许可禁止排入地下水，水道或者污水系统。
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