Choline Chloride 氯化胆碱

CAS 67-48-1 MFCD00011721

化学结构图

67-48-1
SMILES: C[N+](C)(C)CCO.[Cl-]

化学属性

Mol. FormulaC5H14ClNO
Mol. Weight139.62
Density1.205
Melting Point302-305 °C
TSCAYes
SolubilitySoluble in water (500 mg/ml), alcohol, ethanol (28 mg/ml at 25 °C), DMSO (28 mg/ml at 25 °C), and methanol.
Appearance 白色吸湿性结晶，无味，有鱼腥臭。Mp240℃。10%水溶液pH5-6，在碱液中不稳定。本品易溶于水和乙醇，不溶于乙醚、石油醚、苯和二硫化碳。低毒，LD 50 (大鼠，经口)3400 mg/kg。
Stability对湿度敏感

别名和识别编码

Chemical NameCholine Chloride
CAS Number67-48-1
Synonym Choline (chloride) {LY} Choline (chloride) {} {LY} Choline (chloride) {} {} {LY} Choline (chloride) {} {} {} {LY} Choline (chloride) {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Choline (chloride) {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number200-655-4
Beilstein Registry Number3563126
MDL NumberMFCD00011721
PubChem Substance ID6209
Merck Number2206
Reaxys-RN3563126
Chemical Name Translation氯化胆碱
Wiswesser Line NotationQ2K1&1&1 &Q &G
LabNetwork Molecule IDLN00196636
InChIInChI=1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1
Canonical SMILESOCC[N+](C)(C)C.[Cl-]
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分类

  • {uni_hamburg} no charge; alcohol; 2fragments; ionic
  • {SNA} Bioactive Small Mole
  • {SNA} Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Artemisia vulgaris, Aspalathus linearis (Rooibos tea), Boswellia carterii, Cell Culture, Chamaemelum nobile (Chamomile tea), Cichorium intybus (Chicory), Citrus aurantium (Seville orange), Companion Products and Reagents, Curcuma longa (Turmeric), Elettaria Cardamomum (Cardamom), Euphorbia sp, Ginkgo biloba, Hordeum vulgare (Barley), Humulus lupulus (Hops), Hypericum perforatum (St John's wort), Insect Platform, Linum usitatissimum (Flax), Nutrition Research, Ocimum basilicum (Basil),
  • {SNA} Analytical Standards,
  • {
  • {SNA} Amino Acid Library Collection,

产品应用

  • Choline acetyltransferase substrate
  • A source of methyl groups for methyl-transfer reactions.
  • Biochem/physiol Actions Acyl group acceptor

相关文献及参考

  • Hartung, C., et al.: Toxicol. Appl. Pharmacol., 12, 486 (1968),
  • Short: III/31a
  • Short: III/10a
  • Sitaram, N., et al.: Life Sci., et al.: 22, 1555 (1978),
  • Merck: 14,2206 Beilstein:4(2)722
  • Merck: 14,2206
  • Short: III/5a

安全信息

Signal word
GHS Symbol
WGK Germany1
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H303 May be harmfully swallowed 吞食可能有害
RTECSKH2975000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition Store at room temperature, keep dry and cool {LY} Store at room temperature, keep dry and cool {} {LY} Store at room temperature, keep dry and cool {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} { {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry an
Hazard Codes Xi 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3400 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - chromodacryorrhea
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 58,87,1945

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 735 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 6,477,1914/1915

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 51,281,1942

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 53 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 ug/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,1,1985

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 500 ug/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7,1,1985

其他信息

  • TCI Shanghai:氯化胆碱 Choline Chloride,>;98.0%(T)(67-48-1)
  • {Chem
  • 参考质量标准二:氮含量9.8%-10.1%，氯含量25.2%-25.6%；检测水溶解试验、三甲胺、铵盐、重金属和灼烧残渣等杂质含量。
  • 所属类别一:饲料添加剂: 维生素添加剂
  • Acros Organics:氯化胆碱 Choline chloride, 99%(67-48-1)
  • 微有鱼腥臭，具咸苦味。易潮解。易溶于水及醇，水溶液几乎呈中性，不溶于醚、石油醚、苯及二硫化碳。在碱性中不稳定。
  • {Chemica
  • 方法三:（1）连续法制备氯化胆碱溶液的三甲胺盐酸盐与一定量的环氧乙烷分别用泵连续送入反应器，反应物在反应器内的停留时间为1-1.5h。反应在搅拌下进行，生成物连续引出，使反应器内的液面保持稳定。反应器引出的氯化胆碱粗产品进入汽提塔，从塔底获得60-80%氯化胆碱液体产品。（2）三甲胺盐酸盐与环氧乙烷反应，然后加有机酸中和并浓缩，制取氯化胆碱。（3）氯乙醇与三甲胺反应制取氯化胆碱。
  • B族维生素:胆碱是人类和动物体内必不可少的基本组成部分，通常被称为B族维生素或维生素B4,是动物机体内维持生理机能所必需的低分子有机化合物，动物体内可以合成，但常需要在饲料中添加，是一种使用量最大的维生素。它在动物体内可以调节脂肪的代谢与转化，预防肝脏和肾脏中的脂肪沉积及其组织变性，促进氨基酸的再形成，提高氨基酸的利用率，节省部分蛋氨酸。 氯化胆碱是目前是最常用最经济人工合成形式的胆碱，是一种水溶性维生素产品，是生物组织中乙酰胆碱、卵磷酯和神经磷酯的组成部分，它可以节约蛋氨酸。是畜、禽、鱼类所需的重要物质，它在动物体内可以调节脂肪的代谢与转化，可以预防肝脏中沉积及其组织变性作为一种甲基的供体，可促进氨基酸的再形成，提高氨基酸的利用率。主要用于添加剂混合到动物的饲料中。在使用过程中，除防止其吸湿潮解外，还要注意的是所有的饲料都一直以添加氯化胆碱做为最后一道工序，因为它对其他维生素有破坏作用，特别是有金属元素存在时，对维生素A、D、K的破坏较快，因此在多维制剂中不应加入胆碱，日常使用添加后的配合饲料应尽快使用。试验表明氯化胆碱对鸡禽类尤为重要。它合成的氨基酸和卵磷脂输送到鸡禽体内各部，能防止脂肪在肝、肾蓄积，加速鸡禽的生长提高产蛋率和孵化率。
  • 参考质量标准三
  • 方法一:(1)环氧乙烷法。由三甲胺与)环氧乙烷反应而得。 将三甲胺乙醇溶液加入反应锅，在
  • F:3-9
  • 下游产品:卡巴胆碱 --> 饲料添加剂
  • MSDS 信息:2-Hydroxy-N,N,N-trimethylethanaminium chloride(67-48-1).msds
  • 参考质量标准一:GBl0818—89 70%的水溶液： 含量/% ≥70.0 PH 6.5～8.0 乙二醇/% ≤0.5 氯乙醇(以Cl - 计)/% ≤0.2 三甲胺 合格 重金属(Pb)/% ≤0.002 灼烧残渣/% ≤0.2 50%的粉剂： 含量/% ≥50.0 加热减量/% ≤4.0 细度(过0.841 mm筛)/% ≥95.0
  • Alfa Aesar:氯化胆碱,98+% Choline chloride, 98+%(67-48-1)
  • 用途一:用于治疗脂肪肝和肝硬化，也用作饲料添加剂，能刺激卵巢多产蛋、产仔及禽畜、鱼类等增重
  • 方法二:氯乙醇和三甲胺甲醇溶液经加热反应、减压浓缩、重结晶制得。
  • 含量分析:精确称取试样约300mg放于250ml锥形烧瓶中，加50ml冰醋酸，在蒸汽浴上加热至完全溶解。冷却后加10ml醋酸汞试液(TS-137)和2滴龙胆紫试剂，用0.1mol/L高氯酸的冰醋酸溶液滴定至绿色终点。同时进行空白试验并作必要校正。每Ml0.1mol/L高氯酸相当于13.96 mg氯化胆碱(C5 H14ClNO)。
  • 所属类别三:食品添加剂: 营养强化剂（营养增补剂）: 维生素
  • Sigma Aldrich:67-48-1(sigmaaldrich)
  • 敏感性:Hygroscopic

系列性分类

  1. Application Areas 应用领域分类
  2. Detergents 去污剂洗净剂
  3. BioUltra Detergents - Detergents
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. C-CH - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Phase Transfer Catalysts 相转移催化剂
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Libraries - Metabolomics
  4. Amino Acid Library - Metabolic Libraries
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Glycerolipid Metabolism - Metabolic Pathways
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Chemical Classification - Nutrition Research
  4. Other Biochemical - Phytochemicals by Chemical Classification
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Allium sativum (Garlic) - Phytochemicals by Plant (Food/Spice/Herb)
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Phase Transfer Catalysts 相转移催化剂
  4. Ammonium Salts - Phase Transfer Catalysts
  1. Life Science 生命科学
  2. Metabolomics 代谢组学
  3. Metabolic Pathways - Metabolomics
  4. Metabolites and Cofactors on the Metabolic Pathways Chart - Metabolic Pathways
  5. TCA - Metabolites and Cofactors on the Metabolic Pathways Chart
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Quaternary Ammonium Compounds 季铵化合物
  1. Functional Group 官能团索引
  2. quaternary ammonium salt
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Libraries
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Libraries
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Lipids
  5. Polyunsaturated
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Libraries
  5. Carbohydrate Library
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Libraries
  6. Carbohydrate Library
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Cofactor
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Metabolomics
  4. Metabolic Pathways
  5. Metabolites and Cofactors on the Metabolic Pathways Chart
  6. Porphyrin
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Lipids
  6. Polyunsaturated
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  7. Cholesterol
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Metabolomics
  5. Metabolic Pathways
  6. Metabolites and Cofactors on the Metabolic Pathways Chart
  7. Porphyrin