CAS 57-13-6 MFCD00008022-Urea 尿素 -LabNovo

Urea 尿素

CAS 57-13-6 MFCD00008022

化学结构图

SMILES: NC(N)=O

化学属性

Mol. Formula	CH4N2O
Mol. Weight	60
Density	1.335
Melting Point	132-135 °C
TSCA	Yes
Solubility	Soluble in water, alcohol, methanol, glycerol, benzene, and conc. HCl. Practically insoluble in chloroform, ether
Refractive index	n20/D 1.40
Appearance	powder
Boiling Point	332.48 °C at 760 mmHg

别名和识别编码

Chemical Name	Urea
Synonym	Urea {LY} Urea {} {LY} Urea {} {} {LY} Urea {} {} {} {LY} Urea {} {} {} {} {LY} Urea {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urea {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number	635724
PubChem Substance ID	1176
CAS Number	57-13-6
EC Number	200-315-5
MDL Number	MFCD00008022
Reaxys-RN	635724
Merck Number	9867
Chemical Name Translation	尿素
Wiswesser Line Notation	ZVZ
LabNetwork Molecule ID	LN00195939
InChI	InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
Canonical SMILES	NC(N)=O

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产品应用

校准仪器和装置；评价方法；工作标准；质量保证/质量控制

安全信息

RTECSYR6250000

WGK Germany1

Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Signal word Warning

GHS Symbol

Safety Statements

S37 Wear suitable gloves 戴适当手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R38 Irritating to skin 刺激皮肤

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P302+P352
P305+P351+P338+P337+P313
P332+P313
P337+P313

Hazard statements

H316 Causes mild skin irritation 会轻微的刺激皮肤

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {

Hazard Codes Xn,Xi Xn

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 821 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 3(5-6),149,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 394 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Blood - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 3(5-6),149,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8471 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitari

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle
   Pathologie.  (Berlin, Ger.) V.254-263, 1966-69.  For publisher information,
   see NSAPCC.  Volume(issue)/page/year: 257,296,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 567 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 30(3),43,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5300 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
   Behavioral - antipsychotic
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 13,749,1977

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 13 gm/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 265 mmol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 628 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,155,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 50 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   25,980,1965

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 16 gm/L/24H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 gm/kg/5D (Continuous)
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 52,877,1987

TYPE OF TEST            : DNA dama

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,28,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrauterine
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 6 gm/kg
SEX/DURATION            : female 18 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 12,372,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   OBGNAS Obstetrics and Gynecology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1953- Volume(issue)/page/year:
   43,765,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraplacental
SPECIES OBSERVED        : Human - woman
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   BJCPAT British Journal of Clinical Practice.  (Medical News Group, 1 Bedford
   St., London WC2E 9HD, UK)  V.10(10)-    1956- Volume(issue)/page/ye

其他信息

Alfa Aesar:尿素,ACS,99.0-100.5% Urea, ACS, 99.0-100.5%(57-13-6)
食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称允许使用该种添加剂的食品中文名称添加剂功能最大允许使用量（g/kg）最大允许残留量（g/kg）尿素食品食品工业用加工助剂 / 一般应在制成最后成品之前出去，有规定食品中残留量的除外
方法二:其制备方法是将经过净化的氨与二氧化碳按摩尔比2.8～4.5混合进入合成塔，塔内压力为13.8～24.6 MPa，温度为180～200℃，反应物料停留时间为25～40min，得到含过剩氨和氨基甲酸铵的尿素溶液，经减压降温，将分离出氨和氨基甲酸铵后的脲液蒸发到99.5％以上，然后在造粒塔造粒得到尿素成品。
所属类别二:农药中间体: 杀菌剂中间体: 脂肪族类杀菌剂
所属类别三:食品添加剂: 小麦粉、淀粉改质剂: 酵母养料
方法三:尿素中哺乳动物体内蛋白质代谢的最终产物。1922年，在德国实现了用
毒性:GRAS(FDA§184.1923，2000)。 LD 50 14300mg/kg(大鼠，经口)。可以使用，胶姆糖胶中不超过3%不致有毒(FAO/WHO，2001)。
用途六:酵母食料；胶姆糖组织改进剂。GB2760-90列为加工助剂。用于含醇饮料、明胶制品、葡萄酒、酵母发酵性焙烤制品。
含量分析:准确称取试样约0.5g，溶于10%硫酸液中并定容至l00ml。取该液5.0ml放入长颈燃烧瓶中，加硫酸试液(TS-240)l0ml，小心加热至不再蒸发出气体。小心煮沸10min，冷却后小心加水40ml。再冷却后放入一蒸汽蒸馏器中。加10mol/LNaOH液50ml，在将蒸汽送经混合液的条件下，小心蒸馏1h。将馏出液约50ml收集于盛有40mL 4%(W/V)硼酸液的收集瓶中。加甲基红/甲烯蓝试液(TS-150)0.25ml，用0.1mol/L盐酸滴定。同时作一空白滴定。每毫升0.1 mol/L盐酸相当于尿素(CH 4 N 2 O)3.003mg。
尿素价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 10023218 脲;尿素;碳酰二胺 500g 12.4元 2011/08/23 100232193 脲;尿素;碳酰二胺 25kg/袋 420元 2011/08/23 10023228 脲;尿素;碳酰二胺 500g 11元
鉴别试验:溶解性易溶于水，溶于乙醇(OT-42)。硝酸沉淀试验试样0.1g溶于水，加浓硝酸1ml。应有白色结晶性沉淀产生。呈色反应于试管中取试
用途三:用于分离氮的氧化物和亚硝酸及色层分析，也用作生物培养剂
方法一:用二氧化碳和氨在高温、高压下合成氨基甲酸铵，经分解、吸收转化后，结晶，分离、干燥而成。
Acros Organics:尿素 Urea, DNAse, RNAse and Protease free, for molecular biology, 99.5%(57-13-6)
下游产品:4-苯基-2-羟基嘧啶-5-羧酸 --> 2-羟基嘧啶-5-羧酸乙酯 --> 粘合剂 104T/C --> 霜脲氰 --> 餐具洗洁精 --> 卡巴胆碱 --> 缩二脲 --> 活性黑KN-BN --> 二氯异氰尿酸钠(C3Cl2N3NaO3) --> 5-尿嘧啶甲酸乙酯 --> 颜料黄 65 --> 2,6-二氯-4,8-二哌啶子基嘧啶并[5,4-D]嘧啶 --> 可降解纺织染整整理剂 --> 1,5-二氢嘧啶并[5,4-D]嘧啶-2,4,6,8-(3H,7H)-四酮 --> 直接耐晒黑G --> 氨基模塑料 --> 冲施肥 --> 呋喃西林 --> 烯丙基脲 --> ZR-01 阻燃剂 --> 1-苯基氨基脲 --> 2,4-二氯噻吩并[3,2-D]嘧啶 --> 2,4-二氯噻吩并[3
图谱信息:尿素(57-13-6)质谱(MS) 尿素(57-13-6)红外图谱(IR1) 尿素(57-13-6)核磁图( 1 HNMR) 尿素(57-13-6)Raman光谱尿素(57-13-6)红外图谱(IR2)