Retinol acetate 维生素A醋酸酯

CAS 127-47-9 MFCD00019413

化学结构图

127-47-9
SMILES: CC(=O)OC/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C

化学属性

Mol. FormulaC22H32O2
Mol. Weight328
Melting Point57-58 °C
TSCAYes
Refractive index1.547-1.555
Solubility可溶
Density0.968
Appearance solid or viscous liquid
Stability对光敏感

别名和识别编码

Chemical NameRetinol acetate
Synonym All-trans-retinol acetate 乙酸维生素A 凝胶 乙酸维生素A Myvak RETINYL ACETATE all-trans-Retinyl acetate Retinol acetate 维生素 A 乙酸酯 乙酸维生素 A 维生素A油醋酸酯 ALL-TRANS VITAMIN A ACETATE 视黄醇乙酸酯 Davitan A 650 维生素A乙酸酯/视黄醇乙酸酯 乙酸维生素A 凝胶, POWDER, 500,000 I.U./G 维生素A醋酸酯 1.0MLU/G TRANS-RETINOL ACETATE Vitamin A acetate Myvax 维生素A标准品 3,7-Dimethyl-9-(2,6,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol acetate 维生素 A 醋酸酯 醋酸维生素 A
CAS Number127-47-9
PubChem Substance ID638034
EC Number204-844-2
Beilstein Registry Number1915439
MDL NumberMFCD00019413
Merck Number14,10013
Chemical Name Translation维生素A醋酸酯
Wiswesser Line NotationL6UTJ A1 B1U1Y1&U2U1Y1&U2OV1 C1 C1
LabNetwork Molecule IDLN00195136
InChIInChI=1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+
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分类

  • {SNA} Bioactives and Supplements for Stem Cell Expansion, Bioactives/Supplements, Cell Biology, General Stem Cell Biology, Nutrition Research, Stem Cell Biology, Stem Cell Differentiation, Stem Cell Expansion, Vitamin A,
  • {SNA} Cell Biology, Nutrition Research, Vitamin A, Vitamins
  • {SNA} Cell Biology, Nutrition Research,
  • {SNA} Analytical Standards,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards,
  • {SNA} Analytical Standar
  • {SNA} Nutrition Research,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards

产品应用

  • 维生素A 油醋酸酯能够维持人体正常代谢,能够维持细胞膜的稳定和发育、维持生殖系统的正常功能,对视觉的形成、缓和组织的角化、增强细胞的免疫能力有明显的作用.

相关文献及参考

  • Merck: 14,10013 Beilstein: 6,IV,4135
  • Merck: 14,10013

安全信息

GHS Symbol
WGK Germany2
Hazard Codes T Xn
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H315 Causes skin irritation 会刺激皮肤
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSVH6825000
Precautionary statements
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R38 Irritating to skin 刺激皮肤
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
  • R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用
Storage condition 避光、防潮、隔氧2-8°C保存. Light & Air Sensitive & Hygroscopic 2-8°C 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51800 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 74,715,1985

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 95 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Endocrine - thyroid tumors
   Skin and Appendages - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 74,715,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAADDB Journal of the American Academy of Dermatology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63141)  1979-
   Volume(issue)/page/year: 6,652,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 432 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3878202

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 umol/L
REFERENCE :
   ONCOBS Oncology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 
     1967-  Volume(issue)/page/year: 44,356,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 100 umol/L
REFERENCE :
   ONCOBS Oncology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 
     1967-  Volume(issue)/page/year: 44,356,1987

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 65600 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 100 umol/L
REFERENCE :
   ONCOBS Oncology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 
     1967-  Volume(issue)/page/year: 44,356,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Mammary gland
DOSE/DURATION           : 3 umol/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 70,949,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Embryo
DOSE/DURATION           : 65600 ug/L
REFERENCE :
   SNSHBT Senshokutai.  Chromosome.  (Sensyokutai Gakkai, Kaokusai Kirisutokyo
   Daigaku, Mitaka, Tokyo-to, Japan)  No.1-    1946-    Adopted new numbering
   in 1976.  Volume(issue)/page/year: (20),574,1980

TYPE OF TES

{

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 826 mg/kg
SEX/DURATION            : female 12-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 18,277,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1205 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 310 mg/kg
SEX/DURATION            : female 10-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 480 mg/kg
SEX/DURATION            : female 6-19 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - viability

其他信息

  • F:1-8-10
  • Alfa Aesar:乙酸维生素A凝胶,powder,500,000I.U./g Vitamin A acetate in gelatin, powder, 500,000 I.U./g(127-47-9)
  • Acros Organics:维他命A乙酸酯 all-trans-Retinyl acetate, 1.5 million IU/g, in sunflower oil, USP/EP, stab.(127-47-9)
  • 用途三:维生素A 油醋酸酯能够维持人体正常代谢,能够维持细胞膜的稳定和发育、维持生殖系统的正常功能,对视觉的形成、缓和组织的角化、增强细胞的免疫能力有明显的作用.
  • 维生素 A 醋酸酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 K9513901 维生素A乙酸酯（-20℃） 1g 234元 2010/06/21 346321000 维生素 A 醋酸酯 all-trans-Retinyl acetate , 1.5 million IU/g, in sunflower oil, USP/EP, stab. 100 GR 1077元 2010/05/25 A16237 乙酸维生素A 凝胶, powder, 500,000 I.U./g Vitamin A acetate in gelatin, powder, 500,000 I.U./g 500g 3710元
  • 用途一:能透皮吸收，抗角质化，刺激胶原蛋白和弹性蛋白的生长，增加表皮及真皮的厚度。增强皮肤弹性，有效消除皱纹，促进皮肤更新，保持皮肤活力。用于眼霜、保湿霜、修护霜、香波、护发素等
  • 用途二:用于维生素A缺乏症
  • MSDS 信息:all-trans Vitamin A acetate(127-47-9).msds
  • Sigma Aldrich:127-47-9(sigmaaldrich)
  • 建议用法:建议在油相中加入维生素 A 醋酸酯（127-47-9），添加量为0.1～1%，应加入适量抗氧剂——BHT，温度宜在60℃左右，溶解即可。
  • 外观:淡黄色结晶；在空气中易氧化，遇光易变质。
  • 显亮黄到淡红色的油溶液.水溶性soluble。室温放置时析出结晶,遇酸、空气、光易氧化。产品在20℃以下保存,原装瓶可保存12个月.如果原装瓶已开瓶使用,剩余部分还需继续保存,必须用隋性气体填充密封,并在20℃以下保存,否则就必须立即用完,
  • MOL 文件:127-47-9.mol

系列性分类

  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Vitamins - Nutrition Research
  4. Vitamin A - Vitamins
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Potable- & Waste-Water Testing - Analytical Reagents
  4. Waste Water - Potable- & Waste-Water Testing
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. R - Alphabetic
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Esters - Carbonyl Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Food & Beverage Standards - Chromatography
  5. Vitamins - Food & Beverage Standards
  6. Fat-Soluble Vitamins - Vitamins
  7. Vitamin A - Fat-Soluble Vitamins
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Stem Cell Biology - Cell Biology
  4. General Stem Cell Biology - Stem Cell Biology
  5. Stem Cell Differentiation - General Stem Cell Biology
  6. Bioactives/Supplements - Stem Cell Differentiation
  7. Vitamins, Hormones, Misc. - Bioactives/Supplements

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