Sodium Dodecyl Sulfate 十二烷基硫酸钠

CAS 151-21-3 MFCD00036175

化学结构图

151-21-3
SMILES: CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+]

化学属性

Mol. FormulaC12H25NaO4S
Mol. Weight288.38
Melting Point204-207
TSCAYes
Density0.37
Solubility溶于水,微溶于醇,不溶于氯仿、醚。
Stability易吸湿
Flash Point>100°C
Appearance white xtl. white solid

别名和识别编码

Chemical NameSodium Dodecyl Sulfate
Synonym Sodium dodecyl sulfate {LY} Sodium dodecyl sulfate {} {LY} Sodium dodecyl sulfate {} {} {LY} Sodium dodecyl sulfate {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sodium dodecyl sulfate {} {} {} {} {} {} {} {} {}
CAS Number151-21-3
PubChem Substance ID3423265
EC Number205-788-1
Beilstein Registry Number3599286
MDL NumberMFCD00036175
Reaxys-RN3599286
Merck Number8636
Chemical Name Translation十二烷基硫酸钠
Wiswesser Line NotationWSQO12 &-NA-
LabNetwork Molecule IDLN00196845
InChIInChI=1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1
Canonical SMILESO=S(OCCCCCCCCCCCC)(O[Na])=O
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分类

  • {SNA} Alkyl Sulfates, Alphabetical, Anionic Detergents, Antigen-Vaccine Preparation, BioUltra, BioUltra Detergents, Biochemicals and Reagents, Cell Culture, Denaturation, Detergents, Detergents N to Z, Detergents by Applications, Diagnostic Ap

产品应用

  • 生化分析,电泳,离子对试剂

相关文献及参考

  • K. Harewood, J.S. Wolff, Anionic detergent for protein solubilization. Anal. Biochem. 55 , 573, (1973)
  • Merck:14,8636
  • Short: IV/1a
  • The reaction rate and endo:exo ratio in the Diels-Alder cycloadditions of acrylic acid derivatives to cyclopentadiene is increased in the presence of this surfactant: Tetrahedron Lett., 27, 1285 (1986).
  • Shor

安全信息

GHS Symbol
WGK Germany2
Hazard Codes 4.1 F,Xn
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302+H332
  • H228 Flammable solid 易燃固体
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSWT1050000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P304+P340+P312
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R10 Flammable 易燃
  • R11 Highly flammable 非常易燃
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R38 Irritating to skin 刺激皮肤
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
UN Number 2926 UN 2926 4.1/PG 2 UN1325 UN2926
Packing GroupII
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {}
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 23-3/1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1288 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 5,763,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 118 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSTGAW Proceedings of the Scientific Section of the Toilet Goods
   Association. (Washington, DC) No.1-48, 1944-67.  Discontinued.
   Volume(issue)/page/year: 3,1,1945

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBS

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 200 mg/L
REFERENCE :
   JDREAF Journal of Dental Research.  (International Assoc. for Dental
   Research, 734 15th St., NW, Suite 809, Washington, DC 20005)  V.1-    1919-
   Volume(issue)/page/year: 55,266,1976

{

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 243 umol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volum

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 12500 nL/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 158,19

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 12500 nL/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 158,19,1985

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 3500 umol/L
REFERENCE :
   JOBAAY Journal of Bacteriology.  (American Soc. for Microbiology, 1913 I
   St., NW, Washington, DC 20006)  V.1-    1916-  Volume(issue)/page/year:
   115,461,1973

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 28,504,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 480 mg/kg
SEX/DURATION            : female 6-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 27,113,1976

其他信息

  • 使用限量:(FDA,§172.822,2000,mg/kg):干蛋白1000;冷冻蛋白125;液体蛋白125;棉花糖(marshmallow)发泡剂,所用明胶量的0.5%;作为表面活性剂,用于由富马酸酸化的固体饮料和富马酸酸化的果汁饮料,25;作为油脂的增湿剂,10(油脂量)。按(FDA,§172.210,2000)规定,可用作柑橘类水果表面涂
  • 阴离子表面活性剂:十二烷基硫酸钠是一种阴离子表面活性剂,属于硫酸酯类表面活性剂的典型代表,简称SDS,又叫AS、K12、椰油醇硫酸钠,月桂醇硫酸钠、发泡剂,市场上销售的商品通常为白色至微黄色结晶粉末,无毒,微溶于醇,不溶于氯仿、醚,易溶于水,与阴离子、非离子复配伍性好,具有良好的乳化性、起泡性、发泡、渗透、去污和分散性能、泡沬丰富,生
  • 十二烷基硫酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30166428 十二烷基硫酸钠 500g 24元 2011/08/23 K7172801 十二烷基硫酸钠 250g 330元 2011/08/23 SL439001 十二烷基硫酸钠 25g 470元
  • Alfa Aesar:<1.5% Sodium n-dodecyl sulfate, 99% (dry wt.), water <1.5%(151-21-3)" href="http://www.alfa.com/zh/GP100w.pgm?DSSTK=A11183&CAS;=151-21-3">正十二烷基硫酸钠,99%(drywt.),water<1.5% Sodium n-dodecyl sulfate, 99% (dry wt.), water <1.5%(151-21-3)
  • 有特殊气味。溶于水呈不透明溶液,溶液呈中性。能乳化脂肪。有湿热空气中分解。有光滑感。1g溶于10ml水中,形成乳状液,水溶液表面张力小,呈中性反应,部分溶于乙醇,几乎不溶于氯仿、乙醚和轻石油。低毒,半数致死量(大鼠,经口)1288mg/kg。有刺激性。溶解度
  • 用途三:GB 2760-96规定为食品工业用加工助剂。发泡剂;乳化剂;阴离子型表面活性剂。用于蛋糕、饮料、蛋白、鲜果、果汁饮料、食用油等。
  • 用途四:用作药物、化妆品、合成树脂的乳化剂。牙膏、灭火器的发泡剂。用作丝毛类精品织物的洗涤剂。金属选矿的浮选剂。
  • 方法一:由十二醇和氯磺酸在40~50℃下经硫酸化生成月桂基硫酸酯,加氢氧化钠中和后,经漂白、沉降、喷雾干燥而成。
  • 用途四:用作药物、化妆品、合成树脂的乳化剂。牙膏
  • 注意事项:禁与其它农药或物质混用。
  • 检测方法:GC
  • 所属类别一:化工助剂: 工业表面活性剂: 阴离子表面活性剂
  • 使用限量:(FDA,§172.822,2000,mg/kg):干蛋白1000;冷冻蛋白125;液体蛋白125;棉花糖(marshmallow)发泡剂,所用明胶量的0.5%;作为表面活性剂,用于由富马酸酸化的固体饮料和富马酸酸化的果汁饮料,25;作为油脂的增湿剂,10(油脂量)。按(FDA,§172.210,2000)规定,可用作柑橘类水果表面涂层用剂,用量以GMP为限。
  • 方法二:十二迷基硫酸钠制备方法很多,目前最常用的有以下两种。 三氧化硫法 反应装置为立式反应器。在32℃下将氮气通过气体喷口进入反应器。氮气流量为85.9 L·min -1 。在82.7 kPa下通入月桂醇,流量58 g·min -1 。将液体三氧化硫在124.1 kPa下通入闪蒸器,闪蒸温度维持在100℃,三氧化硫流量控制在0.907 2 kg·h -1 。然后将硫酸化产物迅速骤冷至50℃,打入老化器,放置10~20min。最后打入中和釜用碱中和。中和温度控制在50℃,当pH值至7~8.5时出料,即得液体成品。喷雾干燥得固体成品。 氯磺化法 间歇法 将月桂醇投入反应釜中,预热至30℃。然后在高速搅拌下将比理论量过量0.03 mol的氯磺酸以雾状喷入醇中。反应温度控制在30~35℃。硫酸化反应结束后,将其打入中和釜用30%的碱液中和至pH值7~8.5。最后用0.4%(质量)的双氧水漂白。喷雾干燥得固体。也可按质量标准配成
  • 方法二:十二迷基硫酸钠制备方法很多,目前最常用的有以下两种。

系列性分类