Tributyltin chloride 三丁基氯化锡
CAS 1461-22-9 MFCD00000521
化学结构图
SMILES: CCCC[Sn](Cl)(CCCC)CCCC
化学属性
| Mol. Formula | C12H27ClSn |
|---|---|
| Mol. Weight | 325 |
| Refractive index | 1.4890 to 1.4920 |
| Boiling Point | 171-173 |
| Density | 1.2 |
| Flash Point | 120°(248°F) |
| TSCA | Yes |
| Melting Point | -9 |
| Vapor Pressure | <;0.01 mmHg ( 20 °C) |
| Solubility | 难溶 |
| Appearance | 无色或浅黄色澄清液体。相对密度1.2105g/ml，闪点 -15℃，沸点171-173℃，折射率1.4930。 |
| pH | :A |
别名和识别编码
| Chemical Name | Chlorotributyltin |
|---|---|
| Synonym | CHLOROTRIBUTYLTIN Chloride tri-n-butyltin Chlorotributyltin Chlortributylzinn Monochlorotributyltin Stannane, chlorotributyl- Stannane, tributylchloro- TBTC TBTC 氯化三丁基锡 TBTC chloride TRIBUTYLTIN(IV) CHLORIDE Tri-n-butylchlorostannane Tri-n-butyltin chloride Tributylchlorostannane Tributylchlorotin Tributylchlorzinn Tributyltin chloride Tributyltin chloride; Tri-n-butyltin chloride; Tributylchlorostannane; TBTC Tributylzinn-chlorid Tributylzinnchlorid Zinntributyl-chlorid chloridtri-n-butylcinicity chloro-tributyl-stannane tri-n-butyl tin maleate tri-n-butyltin tri-n-butyltin chloride tri-n-butyltin hydride |
| CAS Number | 1461-22-9 |
| PubChem Substance ID | 15096 |
| EC Number | 215-958-7 |
| Beilstein Registry Number | 3535715 |
| MDL Number | MFCD00000521 |
| Reaxys-RN | 3535715 |
| Chemical Name Translation | 三丁基氯化锡 |
| Wiswesser Line Notation | G-SN-4&4&4 |
| InChI | InChI=1S/3C4H9.ClH.Sn/c3*1-3-4-2;;/h3*1,3-4H2,2H3;1H;/q;;;;+1/p-1 |
| LabNetwork Molecule ID | LN00195090 |
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分类
- {uni_hamburg} no charge; metal-organic; 1fragment
- {SNA} Alphabetical Index o
- Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, Method Specific, Oeko-Tex Standard 100, Organotin Compounds, Pesticides & Metabolites, Q-Z, T, TA - TE
- {SA} Alpha sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, Method Specific, Oeko-Tex Standard 100, Organotin Compounds, Pesticides & Metabolites, Q-Z, T,
- {SNA} Chemical Synthesis,
产品应用
- 催化剂。合成中导入三丁基锡基团。前列腺素合成。具有防腐、杀菌、防霉等作用。广泛用于木材防腐，船舶油漆等。同时作为医药中间体广泛应用於医药行业。
相关文献及参考
- For use in stannylation of allylic chlorides via the ultrasound-promoted Barbier reaction with Mg, see: Chem. Lett., 1857 (1986); Org. Synth. Coll, 9, 707 (1998). For an example of stannylation of indoles as a route to 2-substituted indoles, see 1-Methylindole, A12605.
- Short: III/35C4
- Organostannanes undergo the Stille coupling reaction, in the presence of Pd catalysts, such as trans-Dichlorobis(triphenylphosphine)palladium(II), 10491, or Tetrakis(triphenylphosphine)palladium(0), 10548, with aryl halides: Angew. Chem. Int. Ed., 25, 508 (1986); J. Org. Chem., 52, 422 (1987), aryl triflates: J. Am. Chem. Soc., 106, 4630 (1984); 108, 3033 (1986); 109, 5478 (1987); Org. Synth. Coll., 9, 553 (1998), or aryl fluorosulfonates: J. Org. Chem., 56, 3493 (1991). LiCl is added in the reaction with triflates to prevent decomposition of the catalyst. These reactions are of wide scope (coupling also occurs with vinyl, allyl or benzyl halides), take place under very mild conditions, and a variety of other functional groups can be tolerated. For recent reviews of the Stille reaction, see: Adv. Met.-Org. Chem., 5, 1 (1996); Org. React., 50, 1 (1997).
- Beilstein:4(3)1926
- Reaction with Grignard or lithium reagents gives alkyl or aryl stannanes.
- See also: A. G. Davies, Organotin Chemistry, Wiley-VCH, N. Y. (1997); H. Nozaki in Organometallics in Synthesis, M. Schlosser, Ed., Wiley, N.Y. (1994), p535; (reviews): Tetrahedron, 45, 909 (1989); J. Organomet. Chem., 437, 23 (1992).
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- H311 Toxic in contact with skin 皮肤接触中毒
- H312 Harmful in contact with skin 皮肤接触有害
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H318 Causes serious eye damage 严重伤害眼睛
- H319 Causes serious eye irritation 严重刺激眼睛
- H330 Fatal if inhaled 吸入致命
- H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
- H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
- H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P203
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P264+P265
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P301+P310
- P301+P310+P330
- P301+P316
- P302+P350
- P302+P352
- P302+P352+P332+P313+P362+P364
- P304+P340
- P305+P351+P338
- P305+P351+P338+P337+P313
- P305+P354+P338
- P307+P311
- P308+P311
- P308+P313
- P308+P316
- P309+P311
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P316
- P317
- P318
- P319
- P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P332+P313
- P332+P317
- P333+P313
- P333+P317
- P337+P313
- P337+P317
- P361+P364
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P362+P364
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R21 Harmful in contact with skin 与皮肤接触有害
- R25 Toxic if swallowed 吞咽有毒
- R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
- R48/23/25
- R50/53
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S35 This material and its container must be disposed of in a safe way 该物料及其容器必须以安全方式处置；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TIUSAD Tin and Its Uses. (Tin Research Institute, 483 W. 6th Ave., Columbus, OH 43201) No.1- 1939- Volume(issue)/page/year: 107,1,1976
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 70 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959- Volume(issue)/page/year: 15,3,1973
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 129 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1250,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 30,505,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DO
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 ng/tube REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,265,1993
TYPE OF TEST : DNA damage TEST SYSTEM : Bacteria - Bacillus subtilis DOSE/DURATION : 10 ug/disk REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,195,1992
TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 30 ug/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,5,1993
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 80 mg/kg SEX/DURATION : female 7-8 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 15,297,1995
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 225 mg/kg SEX/DURATION : female 7-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 13,283,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 321 mg/kg SEX/DURATION : female 13-15 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 16,71,1996
TYPE OF TEST : TDLo -
其他信息
- Sigma Aldrich:1461-22-9(sigmaaldrich)
- 用途二:催化剂。合成中导入三丁基锡基团。前列腺素合成。具有防腐、杀菌、防霉等作用。广泛用于木材防腐，船舶油漆等。同时作为医药中间体广泛应用於医药行业。
- 海关编码:29310095
- Acros Organics:三正丁基氯化锡 Tri-n-butyltin chloride, tech., 90%(1461-22-9)
- 图谱信息:三丁基氯化锡(1461-22-9)红外图谱(IR1) 三丁基氯化锡(1461-22-9)核磁图( 13 CNMR) 三丁基氯化锡(1461-22-9)质谱(MS) 三丁基氯化锡(1461-22-9)核磁图( 1 HNMR)
- 下游产品:盐酸特比萘芬 --> 三丁基乙烯基锡 --> 三丁基氧化锡
- F:3-9-21
- Alfa Aesar:三正丁基氯化锡,96% Tri-n-butyltin chloride, 96%(1461-22-9)
- MSDS 信息:Chlorotributyltin(1461-22-9).msds
- 用途一:具有防腐、杀菌、防霉等作用。广泛用于木材防腐，船舶油漆等。同时作为医药中间体广泛应用於医药行业。
- 溶于乙醇、庚烷、苯和甲苯，不溶于冷水。遇热水水解。有毒。有腐蚀性。
- 蒸气压:<;0.01 mm Hg ( 20 °C)
- 三丁基氯化锡价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010252 三丁基氯化锡;氯化三丁基锡 100g 180元 2011/04/16 T0363 三丁基氯化锡 Tributyltin Chloride 25G 260元 2011/04/16 T0363 三丁基氯化锡 Tributyltin Chloride 500G 2160元
- MOL 文件:1461-22-9.mol
- 敏感性:Moisture Sensitive
- TSCA:Yes
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