Acetyl Bromide 乙酰溴

CAS 506-96-7 MFCD00000114

化学结构图

506-96-7
SMILES: CC(=O)Br

化学属性

Mol. FormulaC2H3BrO
Mol. Weight123
Refractive index1.4480 to 1.4520
Vapor Density4.3 (vs air)
Boiling Point75-77
Vapor Pressure92.2 mmHg ( 25 °C)
Density1.663
Melting Point-96
Flash Point>75°(167°F)
TSCAYes
Solubility起反应
Stability对湿度敏感

别名和识别编码

Chemical NameAcetyl Bromide
Synonym 1-Bromoacetaldehyde 1-Bromoethanal 1-Bromoethanone ACETALBROMIDE ACETIC ACID BROMIDE ACETYL BROMIDE Acetoxybromid Acetyl Bromide( Controlled Chemical) Acetyl bromide, 98+% AcetylBromideForSynthesis Acetylbrimide Acetylbromid Bromideacetyl CH3COBr Essigsäurebromid acetyl bromide ethanoyl bromide ethanoylbromide {} {} {} {} {} {} {} {} {uni_hamburg} 乙酰基溴 乙酰溴 乙醯溴 溴(化)乙酰 溴乙酰 溴乙酰, 98+% 溴乙酰，溴化乙酰，乙酰基溴 溴化丙酯 溴化乙酰 溴化乙醯 溴化醋酰
MDL NumberMFCD00000114
CAS Number506-96-7
PubChem Substance ID10482
EC Number208-061-7
Beilstein Registry Number1697546
Merck Number82
Reaxys-RN1697546
Chemical Name Translation乙酰溴
Wiswesser Line NotationEV1
LabNetwork Molecule IDLN00222876
InChIInChI=1S/C2H3BrO/c1-2(3)4/h1H3
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分类

  • {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {uni_hamburg} no charge; carbonyl bromide; 1fragment

产品应用

  • 该品用于有机合成，染料中间体。

相关文献及参考

  • In the presence of ZnCl2, adds to a wide range of aldehydes, giving ɑ-bromoalkyl acetates: Helv. Chim Acta, 61, 2047, 2059, 2165 (1978); Synthesis, 593 (1978).
  • In combination with TFA, OH groups can be acetylated selectively in the presence of primary and secondary amines: J. Med. Chem., 16, 630 (1973); 17, 427 (1974); Synthesis, 249 (1975).
  • Merck: 14,82 Beilstein:2(4)398
  • Short: III/20b
  • Merck: 14,82
  • Short: II/4
  • Short: II/25B

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H227 Combustible liquid 可燃液体
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSAO5955000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P302+P352
  • P302+P361+P354
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P316
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
  • P403 Store in a well-ventilated place. 储存在通风良好的地方。
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Packing GroupII
UN Number 1716 UN1716
Risk Statements
  • R14 Reacts violently with water 遇水会猛烈反应
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Storage condition Moisture Sensitive 对湿度敏感。
Hazard Codes 8 C
Hazard Class8
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 20(12),52,1976

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 48 gm/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 18(4),55,1974

Restrict 危险品

其他信息

  • 外观性质:无色发烟液体，露置空气中变黄。
  • 毒性分级:中毒
  • 用途一:用作染料、医药、农药中间体和其他有机合成中间体
  • 储运特性:库房通风低温干燥; 与碱、氧化剂、醇分开存放
  • MOL 文件:506-96-7.mol
  • 可燃性危险特性:易燃; 受热分解有毒溴化氢气体和剧毒碳酰溴; 遇水、乙醇放出氢溴酸
  • MSDS 信息:乙酰溴(506-96-7).msds
  • 方法一:乙酐加溴在80℃溴化，之后在95℃-125℃之间把溴加完。约用2.5h。加完后，继续回流3h，放置过夜。用分馏的方法精制。
  • Sigma Aldrich:506-96-7(sigmaaldrich)
  • 蒸气密度:4.3 (vs air)
  • 无色发烟液体。在空气中渐变黄色，遇水、醇和丙酮起剧烈反应。溶于苯，醚和氯仿。
  • 图谱信息:乙酰溴(506-96-7)质谱(MS) 乙酰溴(506-96-7)核磁图( 13 CNMR) 乙酰溴(506-96-7)红外图谱(IR1) 乙酰溴(506-96-7)核磁图( 1 HNMR)
  • 乙酰溴价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80000860 溴乙酰 100ml 179元 2011/08/23 80000816 溴乙酰 100ml 179元 2011/04/16 A0080 乙酰溴 Acetyl Bromide 500G 904元
  • 蒸气压:92.2 mm Hg ( 25 °C)
  • 海关编码:29159080
  • 类别:腐蚀物品
  • TCI Shanghai:乙酰溴 Acetyl Bromide,>;97.0%(T)(506-96-7)
  • 下游产品:4-溴-2-甲基吡啶 --> 4-溴吡啶-2-羧酸 --> γ-三甲铵-β-羟基丁酸 --> 头孢地尼 --> 溴化乙酰胆碱 --> 三苯基甲基溴 --> 扎西他滨
  • Acros Organics:乙酰溴 Acetyl bromide, 98%(506-96-7)
  • 灭火剂:干粉、二氧化碳
  • 用途二:该品用于有机合成，染料中间体。
  • F:9-21
  • Alfa Aesar:溴乙酰,98+% Acetyl bromide, 98+%(506-96-7)
  • 急性毒性:腹腔-小鼠 LD50: 250 毫克/公斤
  • 敏感性:Moisture Sensitive

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)

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