Sebacic Acid 癸二酸

CAS 111-20-6 MFCD00004440

化学结构图

111-20-6
SMILES: O=C(O)CCCCCCCCC(=O)O

化学属性

Mol. FormulaC10H18O4
Mol. Weight202.25
Boiling Point374.3 °C at 760 mmHg
Melting Point131-134.5 °C
Density1.271
Flash Point220°(428°F)
TSCAYes
Vapor Pressure1 mmHg ( 183 °C)
Solubility微溶于水，溶于酒精和乙醚。
Stability对湿度敏感
Appearance 白色片状结晶。 微溶于水，溶于酒精和乙醚。
Refractive index1.422

别名和识别编码

Chemical NameSebacic Acid
Synonym Decanedioic acid {LY} Decanedioic acid {} {LY} Decanedioic acid {} {} {LY} Decanedioic acid {} {} {} {LY} Decanedioic acid {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Decanedioic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number1210591
PubChem Substance ID87575652
CAS Number111-20-6
EC Number203-845-5
MDL NumberMFCD00004440
Reaxys-RN1210591
Merck Number8415
Chemical Name Translation癸二酸
Wiswesser Line NotationQV8VQ
LabNetwork Molecule IDLN00197438
Canonical SMILESO=C(O)CCCCCCCCC(O)=O
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Biochemicals and Reagents, Building Blocks, C10, Carbonyl Compounds, Carboxylic Acids, Chemical Synthesis, Dicarboxylic Acids, Fatty Acids and conjugates, Fatty Acyls, Lipids, Organic Building Blocks
  • {SNA} Biochemicals and Reagents, Building Blocks,

产品应用

  • 气相色谱减尾剂，分离分析脂肪酸，可用于沉淀及定量测定钍，并使钍与铈及其他稀土元索分离。增塑剂、合成树脂和合成纤维。

相关文献及参考

  • Merck:14,8415
  • Merck:14,8415 Beilstein:2,718
  • Short: III/38B
  • Short: III/5a
  • Short: IV/18B
  • [1]. Bertuzzi A, et al. Sebacic acid binding to human plasma albumin. Biochem Pharmacol. 1993 Feb 9;45(3):697-702.

安全信息

WGK Germany1
RTECSVS0875000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word Warning
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P337+P313
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
Hazard Codes Xi
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store a 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6 gm/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   34,1196,1940

TYPE OF TEST            : LD50 - Lethal dose, 50 percen

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 14375 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
   Behavioral - food intake (animal)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 57(2),17,1992

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >4500 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 57(2),17,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-

其他信息

  • 常规方法:用编织袋或麻袋内衬塑料袋包装，每袋净重25、40、45或50kg。贮存于阴凉通风处，防火防潮。勿与液酸和碱混放。按易燃品规定贮运。
  • 下游产品:清洗剂 --> 14-甲基十五烷酸 --> 褐煤酸 --> 1-芘癸酸 --> 1,10-癸二醇 --> 癸二酸二丁酯 --> 癸二酸二异辛酯 --> 尼龙-1010 --> 癸二酸二辛酯 --> 仲辛醇 --> 癸二酸二乙酯 --> 癸二
  • 灭火剂:干粉、泡沫、砂土, 水
  • 能溶于醇类、酯类和酮类，
  • 毒性分级:低毒
  • 主要制备方法:(1)以蓖麻油为原料，将其中的蓖麻醇酸分离出来，与苛性钠在加压及280～300℃ 下进行碱熔，加热反应10h，可制得皮脂酸的钠盐，同时副产2-辛醇。将钠盐溶于水，加入硫酸中和，脱色后，将溶液冷却，析出皮脂酸，用冷水洗，最后重结晶。 CH3(CH2)5CH(OH)CH2CH=CH(CH2)7COOH+ 2NaOH→CH3(C
  • 上游原料:氢氧化钠 --> 硫酸 --> 四氯化碳 --> 蓖麻油 --> 环戊酮 --> 挥发性漆稀释剂 --> 环戊烯 --> 单酯 --> 200#溶剂油 --> 癸烷 --> 癸二酸双钠盐 --> 润滑脂 --> 癸二酸单钠盐 --> 蓖麻油酸钠
  • Alfa Aesar:癸二酸,98+% Sebacic acid, 98+%(111-20-6)
  • 方法一:以天然的蓖麻油或已二酸单酯为原料制得。用乙烯、四氯化碳经聚合反应也可得到癸二酸，但目前世界上工业生产的癸二酸几乎全部都是用蓖麻油作原料的。1.蓖麻油裂解法蓖麻油在碱作用下加热水解生成蓖麻油酸钠皂，然后加硫酸酸解生成蓖麻油酸；在稀释剂甲酚的存在下，加碱加热到260-280℃进行裂解，生成癸二酸双钠盐及仲辛醇和氢气，裂解物经水稀释后，加热加酸中和，把双钠盐变成单钠盐；再用活性炭脱色后的中和液煮沸加酸，使癸二酸单钠盐变成癸二酸结晶析出，再经分离、干燥即得成品。原料消耗定额：蓖麻油（工业品）2100kg/t、硫酸（98%）1600kg/t、烧碱（95%）1200kg/t、甲酚（工业品）100kg/t。2.石油正癸烷发酵法利用200＃溶剂油或166－182℃馏分中分离制得的正癸烷，以19-2解脂假丝酵母发酵制得癸二酸。3.新环戊酮法以钯盐-铜或铁为催化剂，在乙醇、丙醇或其他醇的溶剂中，在40－60℃低温和常压的缓和条件下，将环戊烯用空气氧化生成环戊酮，然后用铁催化剂氧化和二聚而成。
  • TCI Shanghai:癸二酸 Sebacic Acid,>;98.0%(GC)(T)(111-20-6)
  • 用途三:主要用作癸二酸酯类增塑剂和尼龙塑模树脂的原料，还可用作耐高温润
  • 类别:易燃液体
  • 皮脂酸价格(试
  • MOL 文件:111-20-6.mol
  • 用途三:主要用作癸二酸酯类增塑剂和尼龙塑模树脂的原料，还可用作耐高温润滑油的原料。其主要酯类
  • 图谱信息:皮脂酸(111-20-6)
  • 急性毒性:口服- 大鼠 LD50: 14375 毫克/ 公斤; 口服- 小鼠 LD50: 6000 毫克/ 公斤
  • Acros Organics:Sebacic acid, pract., 90%(111-20-6)
  • 储运特性:库房通风低温干燥
  • 用途二:用作分析试剂等
  • 防护措施:癸二酸基本无毒，但生产中所用甲酚有毒，要防止中毒（参见甲酚）。生产设备应密闭。操作人员应戴口罩及手套。
  • 上游原料:氢氧化钠 --> 硫酸 --> 四氯化碳 -
  • 皮脂酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30163860 癸二酸;辛二甲酸;皮脂酸 250g 35元 2011/08/23 40050960 癸二酸;辛二甲酸;皮脂酸 25g 12.3元 2011/08/23 40050961 癸二酸;辛二甲酸;皮脂酸 25g 12.3元
  • 用途一:用作耐寒增塑剂、树脂及尼龙等的原料

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids - Carbonyl Compounds
  6. C10 - Carboxylic Acids
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Fatty Acyls - Lipids
  5. Fatty Acids and conjugates - Fatty Acyls
  6. Dicarboxylic Acids - Fatty Acids and conjugates
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Carboxylic Acids
  6. C1 to C5
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Lipids
  4. Fatty Acids
  5. Saturated fatty acids and derivatives
  6. Branched fatty acids
  7. Others
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)