CAS 77-86-1 MFCD00004679-Tris(hydroxymethyl)aminomethane 三羟甲基氨基甲烷 -LabNovo

Tris(hydroxymethyl)aminomethane 三羟甲基氨基甲烷

CAS 77-86-1 MFCD00004679

化学结构图

SMILES: NC(CO)(CO)CO

化学属性

Mol. Formula	C4H11NO3
Mol. Weight	121.14
Boiling Point	219-220 °C at 10 mmHg
Melting Point	167-172°C
Density	1.353
TSCA	Yes
Solubility	550 G/L (25 ºC)
Flash Point	732°C
Appearance	白色结晶或粉末。熔点171-172℃ ，沸点219-220℃ /1.3kPa，溶于乙醇和水，微溶于乙酸乙酯、苯、不溶于乙醚、四氯化碳，对铜、铝有腐蚀作用，有刺激性。 crystalline
Stability	对湿度敏感

别名和识别编码

Chemical Name	Tris(hydroxymethyl)aminomethane
CAS Number	77-86-1
Alfabeta Name	AMINOHYDROXYMETHYLPROPANEDIOL 2213()-----,
MDL Number	MFCD00004679
Synonym	THAM {LY} THAM {} {LY} THAM {} {} {LY} THAM {} {} {} {LY} THAM {} {} {} {} {LY} THAM {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} THAM {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	6503
EC Number	201-064-4
Beilstein Registry Number	741883
Reaxys-RN	741883
Merck Number	9772
Chemical Name Translation	三羟甲基氨基甲烷
Wiswesser Line Notation	Q1XZ1Q1Q
LabNetwork Molecule ID	LN00335089
InChI	InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
Canonical SMILES	OCC(CO)(N)CO

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产品应用

生物缓冲剂，缓冲范围pH7.0-9.0。酸性气体吸收剂。酸量滴定法基准物质。电流滴定法测定蛋白质中的巯基。纸上电泳分离血清蛋白。淀粉平板电泳分离毒素。

安全信息

Warnings IRRITANT

GHS Symbol

WGK Germany2

Hazard Codes Xi Xi,N,C,F+,F

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, Gloves

RTECSTY2900000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P352
P302+P352+P332+P313+P362+P364
P304+P340
P305+P351+P338
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning

Safety Statements

S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S18 Handle and open container with care 小心搬运和开启容器；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S37 Wear suitable gloves 戴适当手套；
S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {}

Packing GroupII

Hazard Class3

UN Number

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1210 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   17,217,1966

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle weakness
   Behavioral - coma
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 22,315,1940

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   110,653,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,419,1990

其他信息

上游原料:甲醇 --> 碳酸钾 --> 钯 --> 多聚甲醛 --> 硝基甲烷 --> 三(羟甲基)硝基甲烷
用途一:主要用于医药中间体
{Chem
用途四:用作有机合成工业的脱水剂、缩合剂及生产香兰素、兔耳草醛、消炎止痛药物、阳离子交换树脂的催化剂。可作聚丙烯腈的溶剂。染织工业用作媒染剂、丝光剂、上浆剂。纺织工业用作生产棉条桶、梭子等材料的原料(棉纤维的助溶剂)，可提高纤维的黏合力。染料工业用作冰染染料显色盐的稳定剂，用于生产活性染料和阳离子染料。用作石油净化剂和活性炭的活化剂。用于浸渍木材使具有防腐性和阻燃性。用作硬纸板和布制品的阻燃剂。用于电镀。用作电焊条的
毒性分级:中毒
海关编码:29221980
Alfa Aesar:三（羟甲基）氨基甲烷,ACS,99.8-100.1%(Assay,driedbasis) Tris(hyd
图谱信息:三羟甲基氨基甲烷(77-86-1)质谱(MS) 三羟甲基氨基甲烷(77-86-1)红外图谱(IR1) 三羟甲基氨基甲烷(77-86-1)核磁图( 13 CNMR) 三羟甲基氨基甲烷(77-86-1)红外图谱(IR2)
方法一:盐酸法将一定量的氧化加入盛有一定量盐酸的反应器中遗反应，生成氯化锌溶液。当溶液的为3.5～4时，经静置沉淀，将清送去第一次提纯，加入氯化钡、高酸钾、氯酸钾等进行净化以除去碲根、铁等杂质。再经静置沉降，把液送去第二次提纯，加人锌粉以阱铅、镉等重金属，经过滤，把滤沼入石墨坡板蒸发器进行浓缩，浓45%的稀氯化锌溶液从高处向低处与火向并流，出口处浓度达98%以上析出结晶，经粉碎，制得氯化锌品。其 ZnO+2HCl→ZnC12+H2O
{Chemica
用途一:用作脱水剂、催化剂、媒染剂、上浆剂、增重剂、防腐剂，还用于电镀、染料、医药、农药等工业
用途二:用作分析试剂、石油净化剂和有机合成脱水剂
{Chemi
下游产品:三氟氯乙烯 --> C.I. 色基45 --> 6-叔丁基间甲酚 --> 3-甲基-1H-吡唑并[3,4-B]吡啶 --> 2-氨基-3-氰基吡啶 --> 4-己基间苯二酚 --> 2-丙酰呋喃,97% --> 2-氯-5-氯甲基噻吩 --> 4-癸基苯胺 --> 1-氯戊烷 --> 聚砜阴离子交换膜 --> 聚苯乙烯型聚乙烯均相阴离子交换膜 --> 1-氯丙烷 --> 碱性品红 --> 氯代异丁烷 --> 4-正丁基苯胺 --> 强碱性苯乙烯系阴离子交换树脂 --> 2-氨基烟酸 --> 5-甲氧基-2-甲基吲哚 --> 2-氨基-5-氯-2'-氟二苯甲酮 --> 4-氯甲基-3,5-二甲基异噁唑 --> 1H-吡唑并[3,4-B]吡啶 --> 依昔苯酮 --> 6-甲氧基-4-甲基喹啉 --> 邻甲酚酞 --> 2-(1-环己烯基)环己酮 --> 酚红 --> 2',4'-二羟基苯己酮 --> 1,1-二氯乙烷 --> 3-氨基-2-萘甲酸 --> 甲酚红
用途三
氯化锌价格(试剂级):更新日期产品编号产品名称包装价
防护措施:氯化锌毒性很强，能剧烈刺激及烧灼皮肤和粘膜，长期与本品蒸气接触时发生变应性皮炎。吸入氯化锌烟雾经5～30min后能引起阵发性咳嗽、恶心。对上呼吸道、气管、支气管粘膜有损害。美国对氯化锌烟雾规定最高容许浓度为1mg/m3。生产人员工作时要穿工作服，戴防护眼镜、防毒口罩、乳胶手套，以保护皮肤、眼睛、呼吸器官。车间通风要良好，下班后要洗热水淋浴。
Alfa Aesar:无水氯化锌,98+% Zinc chloride, anhydrous, 98+%(7646-85-7)
氯化锌价格(试剂级):更新日期产品编号产
Sigma Aldrich:7646-85-7(sigmaaldrich)
{Ch
F:3
color:white
MOL 文件:7646-85-7.mol
敏感性:Hygroscopic
蒸气压:1 mm Hg