Acridine 吖啶

CAS 260-94-6 MFCD00005025

化学结构图

260-94-6
SMILES: c1ccc2nc3ccccc3cc2c1

化学属性

Mol. FormulaC13H9N
Mol. Weight179.22
Boiling Point346
Melting Point108.0 to 112.0 deg-C
Density1.005
TSCAYes
Flash Point346°C
Solubilitydioxane: 0.1 g/mL, clear

别名和识别编码

Chemical NameAcridine
CAS Number260-94-6
Synonym Acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {Chemicalbook} benzo(b)quinoline {} {} {} {} {} {} {} {} {} {} {uni_hamburg} Dibenzo[b, e]pyridine {} {} {} {} {} {} {} {} {} {} {} {hazard_com} Dibenzo(b,e)pyridine {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} Coal tar pitch volatiles:acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {uni_hamburg} Acrydine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Acridines {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {Chemicalbook} Acridine, 98+% {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acridine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID9215
EC Number205-971-6
Beilstein Registry Number20(3/4)3987
MDL NumberMFCD00005025
Reaxys-RN120200
Merck Number122
Chemical Name Translation吖啶
Wiswesser Line NotationT C666 BNJ
LabNetwork Molecule IDLN01111326
InChIInChI=1S/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H
Canonical SMILESC12=NC3=CC=CC=C3C=C1C=CC=C2
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分类

  • Alphabetical, Biochemicals and Reagents, Fluorescent Probes, Labels, Particles and Stains, Fluorescent Stains, Luminescent Compounds/Detection, Nucleic Acid Stains, Stains and Dyes
  • {SNA} Alphabetical, Fluorescent Stains, Nucleic Acid Stains, Stains and Dyes, 发光化合物及其检测,

产品应用

  • 用于制吖啶染料，也用作荧光pH值指示剂。制造染料和药物(如吖啶黄素和奎吖因)的重要母体化合物。

相关文献及参考

  • Short: II/27B
  • Merck: 14,122
  • Merck: 14,122 Beilstein: 20,V,8,199 / Beil. 20,459
  • Pathak, D. et al.: Pharma Chemica, 3, 239 (2011); Mathieu, O. et al.: Xenobiotica, 41, 91 (2011); Rubbo, S.D. et al.: Br. J. Exp. Pathol., 28, 1 (1947);

安全信息

GHS Symbol
WGK Germany3
Hazard Codes Xn
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSAR7175000
Signal word
UN Number 2713
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P301+P317
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R51/53
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Packing GroupIII
Hazard Class6.1
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - somnolence (general depressed activity)
   Behavioral - excitement
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 14(9),56,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJEPA5 British Journal of Experimental Pathology.  (Blackwell Scientific
   Pub. Ltd., POB 88, Oxford, UK)  V.1-    1920-  Volume(issue)/page/year:
   28,1,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJEPA5 British Journal of Experimental Pathology.  (Blackwell Scientific
   Pub. Ltd., POB 88, Oxford, UK)  V.1-    1920-  Volume(issue)/page/year:
   28,1,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - necrotic changes
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases.

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bird - chicken Leukocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   JMOBAK Journal of Molecular Biology.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year: 3,18,1961

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 230 nmol/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 3,11,1981

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   JMOBAK Journal of Molecular Biology.  (Academic Press, Inc., 1 E. First St.,
   Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year: 3,18,1961

Restrict 危险品

其他信息

  • Sigma Aldrich:260-94-6(sigmaaldrich)
  • 灭火剂:二氧化碳、砂土、泡沫
  • 毒性分级:中毒
  • Alfa Aesar:吖啶,98+% Acridine, 98+%(260-94-6)
  • Acros
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 图谱信息:10-氮(杂)蒽 (260-94-6)红外图谱(IR1) 10-氮(杂)蒽 (260-94-6)质谱(MS) 10-氮(杂)蒽 (260-94-6)核磁图( 1 HNMR) 10-氮(杂)蒽 (260-94-6)红外图谱(IR2) 10-氮(杂)蒽 (260-94-6)核磁图( 13 CNMR)
  • {Chemi
  • 可燃性危险特性:受热分解有毒氧化氮气体
  • 用途一:吖啶的结构与蒽相似，化学性质也很接近。吖啶苯环上的氢被氨基取代后，是吖啶染料的中间体。在吖啶化合物中，有的具有防腐性，可用作医药，例如吖啶黄和阿的平。
  • 类别:有毒物品
  • 上游原料:锌粉 --> N-苯基邻氨基苯甲酸 --> 吖啶酮
  • 下游产品:咔唑
  • 急性毒性:口服-大鼠 LD50: 2000 毫克/公斤; 口服-小鼠 LD50: 500 毫克/公斤
  • {C
  • {Chemical
  • 用途二:用于制吖啶染料，也用作荧光pH值指示剂。制造染料和药物(如吖啶黄素和奎吖因)的重要母体化合物。
  • 职业标准:TWA 0.2 毫克/立方米
  • TCI Shanghai:吖啶(区域精制法精制,熔段数:45) Acr
  • MSDS 信息:吖啶(260-94-6).msds
  • MOL 文件:260-94-6.mol
  • 易溶于乙醇、乙醚、烃类和二硫化碳，微溶于沸水。具
  • 用途二:用于制吖啶染料，也用作荧光pH值指示剂。制造染料和药物(如吖啶黄素和奎吖因)的重要

系列性分类

  1. Life Science 生命科学
  2. Hematology and Histology 血液学和组织学
  3. Stains and Dyes - Hematology and Histology
  4. Stains & Dyes, A to Z - Stains and Dyes
  5. A - Stains & Dyes, A to Z
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Fluorescent Probes, Labels, Particles and Stains - Biochemicals and Reagents
  4. Fluorescent Stains - Fluorescent Probes, Labels, Particles and Stains
  5. Nucleic Acid Stains - Fluorescent Stains
  6. Alphabetical - Nucleic Acid Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Solvents, Buffers and Reagents for Luminescence
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Fluorescent Probes, Labels, Particles and Stains
  4. Fluorescent Stains
  5. Nucleic Acid Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Luminescent Compounds/Detection
  4. Fluorescent Probes, Labels, Particles and Stains
  5. Fluorescent Stains
  6. Nucleic Acid Stains

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