• 原料直供
• 试剂商城
• 直接询价

分类

• Heterocycles
• {uni_hamburg} no charge; nitrogen heterocycle; alicycle; 5ring; amide; lactame; 1fragment
• Miscellaneous Reagents
• {SNA} C-X Bond Formation (Halogen), Chemical Synthesis, Iodination, Synthetic Reagents

产品应用

• 用于有机合成，硫的氧化滴定试剂， 用作温和的碘化剂、硫苷催化剂等。

相关文献及参考

• Oxidative coupling of dianions of acyclic tertiary amides gives a stereoselective preparation of ß-lactams: J. Org. Chem., 57, 1864 (1992):
• In the presence of triphenylphosphine or triphenyl phosphite, converts alcohols to iodides stereoselectively with inversion: Tetrahedron Lett., 3937 (1973). See also: Carbohydr. Res., 24, 45 (1972).
• Source of positiv
• With K2CO3 in MeOH, aldehydes can be oxidized directly to methyl esters: J. Org. Chem., 54, 1213 (1989).
• In combination
• Has been used in the construction of disulfide bridges in cystine peptides, from cysteine in a DMF-dichloromethane solvent: J. Org. Chem., 58, 3003 (1993).
• Castanet, A.-S. et al.: Tetrahed. Lett., 43, 5047 (2002);
• Alone or with a catalytic amount of triflic acid, is a powerful coupling agent in oligosaccharide synthesis, particularly for thioglycosyl donors; see, e.g.: Tetrahedron Lett., 34, 8523 (1993). For reviews, see: Chem. Rev., 93, 1503 (1993); Contemp. Org. Synth., 3, 173 (1996).
• In combination with TFA and TFA anhydride, iodinates 2,4-diethoxypyrimidines or N-alkyluracils specifically to their 5-iodo-derivatives: Synth. Commun., 18, 855 (1988). With triflic acid, the "superelectrophile" iodine(I) triflate is formed. This species will iodinate even deactivated aromatics, e.g. nitrobenzene to the m-iodo derivative: J. Org. Chem., 58, 3194 (1993).
• Short: EINECS
• Short: III/5a
• In combination with the phase-transfer catalyst, Tetra-n-butyl­ammonium iodide, A15484, oxidizes alcohols to carbonyl compounds in high yield under neutral conditions: Synthesis, 394 (1981). Glycols are cleaved to carbonyl compounds; the rate of reaction is increased by u.v. irradiation: J. Org. Chem., 46, 1927 (1981). Similarly, ɑ-hydroxyacids are oxidatively decarboxylated to ketones: J. Org. Chem., 47, 3006 (1982).
• For a brief feature on uses of the reagent in synthesis, see: Synlett, 960 (2006).

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02815

其他信息

• 用途一:主要作为生物制药中的医药中间体
• 上游原料:1,4-二氧六环 --> 丁二酰亚胺 --> 二亚胺
• Alfa Aesar:N-碘化丁二酰胺,97+% N-Iodosuccinimide, 97%(516-12-1)
• MOL 文件:516-12-1.mol
• 用途二:在有机合成中用于酮类、醛类的碘化。
• Acros Organics:N-碘代琥珀酰亚胺 N-Iodosuccinimide, 98%(516-12-1)
• 水中分解，溶于丙酮、甲醇，中度溶于二氧六环，微溶于二氯甲烷和醚，实际上不溶于四氯化碳。
• 图谱信息:N-碘代丁二酰亚胺(516-12-1)核磁图( 13 CNMR) N-碘代丁二酰亚胺(516-12-1)红外图谱(IR2) N-碘代丁二酰亚胺(516-12-1)红外图谱(IR1) N-碘代丁二酰亚胺(516-12-1)核磁图( 1 HNMR)
• 检测方法:T,NMR
• 敏感性:Moisture Sensitive
• F:8-9
• Hazard Note:Harmful/Keep Cold/Moisture Sensitive
• 下游产品:4,5-二甲氧基-3-碘苯甲醛 --> 2,4-二甲氧基-5-碘嘧啶 --> 2-氯-4-硝基苯-alpha-L-岩藻糖苷
• TCI Shanghai:N-碘代琥珀酰亚胺 N-Iodosuccinimide,>;98.0%(T)(516-12-1)
• 存储注意事项:氮气保护
• 方法一:在避光条件下，使丁二酰亚胺与氧化银反应，制取N-丁二亚胺银。将其和碘在干燥的二氧六环中反应，生成N-碘琥珀酰亚胺。
• 海关编码:29251995
• 用途三:用于有机合成，硫的氧化滴定试剂， 用作温和的碘化剂、硫苷催化剂等。
• N-碘代丁二酰亚胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 I0074 N-碘琥珀酰亚胺 N-Iodosuccinimide 100G 3150元 2014/06/02 I0074 N-碘琥珀酰亚胺 N-Iodosuccinimide 25G 1020元 2014/06/02 I0074 N-碘琥珀酰亚胺 N-Iodosuccinimide 5G 325元
• Sigma Aldrich:516-12-1(sigmaaldrich)
• MSDS 信息:1-Iodo-2,5-pyrrolidinedione(516-12-1).msds