Pyrazine 吡嗪

CAS 290-37-9 MFCD00006122

化学结构图

290-37-9
SMILES: c1cnccn1

化学属性

Mol. FormulaC4H4N2
Mol. Weight80.09
Boiling Point118.6°C at 760 mmHg
Melting Point50-56°C
TSCAT
Density1.031
Refractive index1.5235
Flash Point55.6°C
SolubilitySoluble in water, alcohol, and ether
Appearance 吡嗪(290-37-9)两个氮原子占1,2两位的称为哒嗪；占1,3两位的称为嘧啶,它们都是吡嗪的 同分异构体。吡嗪是无色晶体，熔点54℃，沸点115～116℃（768毫米汞柱），液态的相对密度1.0311（61／4℃）。具有与吡啶类似的气味。溶于水、乙醇、乙醚等。 吡嗪是一个很弱的碱。它的芳香性与吡啶类似，很不容易发生亲电取代反应，而对亲核试剂比较活泼。碳原子上的氢被甲基或卤素取代后，卤素或甲基上的氢具有活性。吡嗪及其衍生物可用多种方法合成。
Stability易吸潮

别名和识别编码

Chemical NamePyrazine
CAS Number290-37-9
Alfabeta NamePYRAZINE
MDL NumberMFCD00006122
EC Number206-027-6
Beilstein Registry Number23,91
Reaxys-RN103905
Merck Number7957
PubChem Substance ID87574722
Synonym Pyrazine {LY} Pyrazine {} {LY} Pyrazine {} {} {LY} Pyrazine {} {} {} {LY} Pyrazine {} {} {} {} {LY} Pyrazine {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Pyrazine {} {} {} {} {} {} {
Chemical Name Translation吡嗪
Wiswesser Line NotationT6N DNJ
LabNetwork Molecule IDLN00110787
InChIInChI=1S/C4H4N2/c1-2-6-4-3-5-1/h1-4H
Canonical SMILESC1=NC=CN=C1
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分类

  • {Chemicalbook} 食品添加剂: 食用香料（增香剂）: 天然等同香料和人造香
  • {SNA} Alcoholic & Nonalcoholic Beverages, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Coffee, Food & Beverage Standards, Grains, Herbs & Spices, Lavender, M-R, P, PU - PZ, Pyrazine, Rice, 化合物分类, 按字母排序, 食品饮料类产品, 香精香料
  • Alphabetical Listings, Flavors and Fragrances, Kosher Certified Products, O-P, O-Z
  • {SNA} Alc
  • {SNA} Alcoholic & Nonalcoholic Beverages, All Alphabetically Sorted,
  • {SNA

相关文献及参考

  • Short: II/25C
  • Short: II/27B
  • Merck: 14,7957 Beilstein:23,91
  • Merck: 14,7957

安全信息

Warnings FLAMMABLE
Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P211 Do not spray on an open flame or other ignition source.? 不要喷洒在明火或其他点火源。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P370+P378
RTECSUQ2015000
UN Number 1325 UN1325
Hazard statements
  • H228 Flammable solid 易燃固体
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes 4.1 F;Xi
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Gloves
Packing GroupII
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Class4.1 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2730 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBPHAW Progress in Biochemical Pharmacology.  (S. Karger AG, Postfach
   CH-4009 Basel, Switzerland) V.1-    1965-  Volume(issue)/page/year:
   1,542,1965

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2500 mg/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 18,581,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 60 gm/L
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 18,581,1980

其他信息

  • 毒性:可用于食品(FAO/WHO，2001)。
  • 1，4位含两个杂氮原子的杂环化合物。与嘧啶和哒嗪互为同分异构体。溶于水、醇和醚。具有较弱的芳香性，与吡啶类似。不易发生亲电取代反应，但易和亲核试剂发生取代反应。
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） 吡嗪 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
  • Alfa Aesar:<1.0%(290-37-9)" href="http://www.alfa.com/zh/GP100w.pgm?DSSTK=A13982&CAS;=290-37-9">吡嗪,99+% Pyrazine, 99+% (dry wt.) water <1.0%(290-37-9)
  • FEMA:4015
  • TSCA:T
  • 用途一:用作医药中间体，香精、香料中间体
  • 1，4位两个杂氮原子的杂环化合物。与嘧啶和哒嗪互为同分异构体。溶于水、醇和醚。具有较弱的芳香性，与吡啶类似。不易发生亲电取代反应，但易和亲核试剂发生取代反应。
  • Sigma Aldrich:290-37-9(sigmaaldrich)
  • MOL 文件:290-37-9.mol
  • 吡嗪价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw050008 吡嗪;1,4-二嗪 100g 600元 2011/04/16 P0544 吡嗪 Pyrazine 500G 3600元 2011/04/16 P0544 吡嗪 Pyrazine 25G 458元
  • 海关编码:29339990
  • Acros Organics:吡嗪 Pyrazine, 99+%(290-37-9)
  • 图谱信息:吡嗪(290-37-9)红外图谱(IR1) 吡嗪(290-37-9)红外图谱(IR2) 吡嗪(290-37-9)核磁图( 1 HNMR) 吡嗪(290-37-9)核磁图( 13 CNMR) 吡嗪(290-37-9)质谱(MS)
  • 参考质量标准:FAO/WHO，2001 含量(GT-10-4) ≥98% 熔点 53℃
  • MSDS 信息:1,4-Diazine(290-37-9).msds
  • TCI Shanghai:1,4-二嗪 Pyrazine,>;98.0%(GC)(290-37-9)
  • 检测方法:GC,NMR
  • 下游产品:氟哌酸 --> 佐匹克隆 --> (6R,7R)-3-[[(1-甲基-1H-四唑-5-基)硫]甲基]-7-[(R)-2-(4-乙基-2,3-二氧代-1-哌嗪甲酰氨基)-2-对羟基苯基-乙酰氨基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸 --> 吡喹酮 --> 2-乙酰基吡嗪

系列性分类

  1. Application Areas 应用领域分类
  2. Flavors and Fragrances 香精香料
  3. Kosher Certified Products - Flavors and Fragrances
  4. O-Z - Kosher Certified Products
  1. Application Areas 应用领域分类
  2. Flavors and Fragrances 香精香料
  3. Alphabetical Listings - Flavors and Fragrances
  4. O-P - Alphabetical Listings
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrans 派兰斯
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrazines 吡嗪
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Pyrazines

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