8-Hydroxyquinoline 8-羟基喹啉

CAS 148-24-3 MFCD00006807

化学结构图

148-24-3
SMILES: Oc1cccc2cccnc12

化学属性

Mol. FormulaC9H7NO
Mol. Weight145.16
Boiling Point267°C at 760 mmHg
Melting Point70-73°C
SolubilitySoluble in acetone, ethanol, chloroform, and benzene. Insoluble in water
TSCAYes
Density1.0015
Stability对光和空气敏感
Flash Point267°C
Appearance 8-羟基喹啉(148-24-3)为白色针状结晶。熔点76℃,沸点266.6℃(100.3kPa)。易溶于乙醇、苯、氯仿、丙酮和稀酸,不溶于水。

别名和识别编码

Chemical Name8-Hydroxyquinoline
CAS Number148-24-3
Synonym 8-Hydroxyquinoline {LY} 8-Hydroxyquinoline {} {LY} 8-Hydroxyquinoline {} {} {LY} 8-Hydroxyquinoline {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 8-Hydroxyquinoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00006807
PubChem Substance ID87570727
Beilstein Registry Number114512
EC Number205-711-1
Reaxys-RN114512
Merck Number4843
Chemical Name Translation8-羟基喹啉
Wiswesser Line NotationT66 BNJ JQ
LabNetwork Molecule IDLN00004701
InChIInChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
Canonical SMILESOC1=C2N=CC=CC2=CC=C1
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分类

  • {SNA} Alphabetical Index of Analytical
  • {SNA} Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents, Building Blocks, C8 to C10, Chemical Structure Class, Chemical Synthesis, Heterocyclic Building Blocks, Inhibits an Enzyme,
  • {SNA} A - K,

产品应用

  • Used as a lipophilic monoprotic bidentate chelating agent.

相关文献及参考

  • Merck:14,4843 Beilstein:21,91
  • Short: II/27B
  • Chelating ligand.
  • Short: II/3
  • Merck:14,4843

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Hazard Codes Xn Xn,Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Signal word Warning
RTECSVC4200000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P301+P312
  • P301+P312+P330
  • P302+P352
  • P304+P312
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P308+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P333+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room te
UN Number 2811 3077
Packing GroupIII
Hazard Class9
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   11,212,1957

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 33 gm/kg/82W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   ARPAAQ Archives of Pathology.  (Chicago, IL)  V.5(3)-50(3), 1928-50;
   V.70-99, 1960-75.  For publisher information, see APLMAS.
   Volume(issue)/page/year: 79,245,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7200 mg/kg/50W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 16(8),67,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 29 gm/kg/48W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 83600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1946-  Volume(issue)/page/year:
   1,150,1946

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Roden

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1210 mg/m3/6H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 11,497,1992

TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1205 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 20,413,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
   New York, Inc., 19

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 25 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 92,427,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 ug/plate
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11(Suppl 12),1,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 7500 ug/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2600 ug/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   FAVUAI Fiziologicheski Aktivnye Veshchestva.  Physiologically Active
   Substances.  (Izdatel'stvo Naukova Dumka, Kiev, USSR)  No.1-    1966-
   Volume(issue)/page/year: 6,118,19

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       :

其他信息

  • 用途三:沉淀和分离金属离子的沉淀剂和萃取剂,能与下列金属离子络合:Cu+2、Be+2、Mg+2、Ca+2、Sr+2、Ba+2、Zn+2、Cd+2、Al+3、Ga+3、In+3、Tl+3、Yt+3、La+3、Pb+2、B+3、Sb+3、Cr+3、MoO+22、Mn+2、Fe+3、Co+2、Ni+2、Pd+2、Ce+3.
  • 下游产品:5-甲氧基甲基-2,3-吡啶二羧酸 --> 8-羟基喹啉-2-羧酸 --> 注射用核糖核酸 --> 8-羟基喹啉铜 --> 8-羟基喹啉-2-甲腈 --> 喹碘方 --> 8-羟基喹啉二硫代磷酸酯络合物 --> 5,7-二氯-8-羟基喹啉 --> 8-羟基喹啉-5-磺酸 --> 5,7-二碘-8-羟基喹啉 --> 5,7-二溴-8-羟基喹啉 --> 5-氯-8-羟基喹啉
  • MSDS 信息:8-Quinolinol(148-24-3).msds
  • Alfa Aesar:8-羟基喹啉,ACS 8-Hydroxyquinoline, ACS(148-24-3)
  • 用途二:该品是卤化喹啉类抗阿米巴药物的中间体,包括喹碘仿、氯碘喹啉、双碘喹啉等。这类药物通过抑制肠内共生菌而发挥抗阿米巴作用,对阿米巴痢疾有效,对肠道外阿米巴原虫无影响。近年来国外报道本类药物能引起亚急性脊髓视神经病,故该药在日本和美国已禁用,双碘喹啉引起此病比氯碘喹啉较少见。8-羟基喹啉也是染料、农药的中间体。其硫酸盐和铜盐是优良的防
  • MOL 文件:148-24-3.mol
  • Acros Organics:8-羟基喹啉 8-Hydroxyquinoline, for analysis ACS(148-24-3)
  • 8-羟基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30104082 8-羟基喹啉;8-氢氧化喹啉;8-羟基氮(杂)萘;邻羟基氮(杂)萘 25g 64元 2011/08/23 30104014 8-羟基喹啉;8-氢氧化喹啉;8-羟基氮(杂)萘;邻羟基氮(杂)萘 25g 14元 2011/08/23 30104017 8-羟基喹啉;8-氢氧化喹啉;8-羟基氮(杂)萘;邻羟基氮(杂)萘 250g 120元
  • 方法一:由邻氨基苯酚经环合反应制得。将甘油加入耐酸反应锅内,在搅拌下缓缓加入浓硫酸,同时将
  • 8-Hydroxyquinoline is a monoprotic bidentate chelating agent The reaction of 8-hydroxyquinoline with aluminium(III) results in Alq3, a common component of organic light-emitting diodes (OLED's). Variations in the substituents on the quinoline rings affect its luminescent properties. 8-Hydroxyquinoline is employed in precipitating and separating metals, the preparation of fungicides, and as a dye
  • 用途二:该品是卤化喹啉类抗阿米巴药物的中间体,包括喹碘仿、氯碘喹啉、双碘喹啉等。这类药物通过抑制肠内共生菌而发挥抗阿米巴作用,对阿米巴痢疾有效,对肠道外阿米巴原虫无影响。近年来国外报道本类药物能引起亚急性脊髓视神经病,故该药在日本和美国已禁用,双碘喹啉引起此病比氯碘喹啉较少见。8-羟基喹啉也是染料、农药的
  • Sigma Aldrich:148-24-3(sigmaaldrich)
  • 用途一:用作医药中间体,是合成克泻痢宁、氯碘喹啉、扑喘息敏的原料,也是染料、农药中间体
  • {C
  • Hazard Note:Harmful/Irritant
  • 图谱信息:8-羟基喹啉(148-24-3)Raman光谱 8-羟基喹啉(148-24-3)核磁图( 1 HNMR) 8-羟基喹啉(148-24-3)质谱(MS) 8-羟基喹啉(148-24-3)核磁图( 13
  • 海关编码:29334

系列性分类


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