Methyllithium 甲基锂

CAS 917-54-4 MFCD00008253

化学结构图

917-54-4
SMILES: [Li]C

化学属性

Mol. FormulaCH3Li
Mol. Weight21.98
Density0.732
Flash Point-17°(1°F)
TSCAYes
Vapor Density3 (vs air)
Appearance 无色透明至黄色的乙醚溶液，遇水剧烈反应，易燃。沸点35℃，密度 0.702 。
Stability对空气,热和湿度敏感
RedoxReduction

别名和识别编码

Chemical NameMethyllithium
Synonym Methyl lithium,1.6M in Diethoxymethane,Safeseal {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {} {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {} {} {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safeseal {} {} {} {} {} {} {} {} {} {} {} {} {LY} Methyl lithium,1.6M in Diethoxymethane,Safes
CAS Number917-54-4
EC Number213-026-4
Beilstein Registry Number3587162
MDL NumberMFCD00008253
PubChem Substance ID2724049
Reaxys-RN3587162
Chemical Name Translation甲基锂
InChIKeyDVSDBMFJEQPWNO-UHFFFAOYSA-N
LabNetwork Molecule IDLN00164399
InChIInChI=1S/CH3.Li/h1H3;/q-1;+1
Canonical SMILESC[Li]
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分类

  • {SNA} 12 Principles Aligned Products, Alkyl, Chemical Synthesis, Greener Alternative Products, Organolithium, Organometalics, Organometallic Reagents
  • {SNA} 25mL Sure/Seal Reagents, Alkyl, Chemical Synthesis, Organic Bases, Organolithium, Organometallic Reagents, Synthetic Reagents
  • {SNA} 25mL Sure
  • {SA} 25mL Sure/Seal Reagents, Alkyl, Chemical Synthesis, Organic Bases, Organolithium, Organometallic Reagents, Synthetic Reagents
  • {SNA} Alkyl, Chemical Synthesis, Organolithium, Organometallic Reagents
  • {uni_hamburg} no charge; metal-organic; 1fragment
  • {SNA} 25mL Sure/Seal Reagents,
  • {SNA} 25mL Sure/Seal Reagents,

产品应用

  • ⑴.本品较为稳定。
  • ⑵. 碱性试剂和还原剂。用于丙二烯合成。a一轻酮转变成顺式二醇，从梭酸制酮。分解醋酸醋。使烯醇乙酸醋成烯醇负离子制a一溴代酮或a，一不饱和酮。合成螺戊烷。从丫一酮酸醋制日一二酮。与日、丫一不饱和酸反应成醋a芳香醛酮的甲基化一还.原。烯基砜的锉化。
  • ⑶. 可以对多种官能团进行甲基化，可以脱除保护基团，合成其它甲基化有机金属试剂，可以作为碱以及还原过渡金属等。溶剂和卤素对用到非溶剂化的甲基锂的反应有很大的影响。
  • ①.加成反应 ；与甲基格氏试剂相比，甲基锂与环烃、杂环以及脂肪族化合物的1,2
  • 有机催化剂反应。

相关文献及参考

  • Short: III/35C4
  • Short: III/20a
  • Short: II/2
  • Beilstein:4(4)4417

安全信息

Signal word
GHS Symbol
WGK Germany2
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用（指明具体的消防器材种类，如果用水增加危险，注明“禁止用水”
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
Risk Statements
  • R12 Extremely flammable 极端易燃
  • R15 Contact with water liberates extremely flammable gases 遇水会释放出极端易燃的气体
  • R17 Spontaneously flammable in air 在空气中能够自燃
  • R22 Harmful if swallowed 吞咽有害
  • R34 Causes burns 会导致灼伤
  • R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
Precautionary statements
  • P222 Do not allow contact with air. 不要与空气接触。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P370+P378
  • P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire. 远离任何与水接触的可能，因为会剧烈反应可能产生闪火。
  • P422 Store contents under… 存储目录在…之下。
  • P231+P232
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P308+P313
  • P403+P233
  • P305+P351+P338+P310
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H260 In contact with water releases flammable gases which may ignite spontaneously 与水接触时释放可燃气体，可自燃。
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H250 Catches fire spontaneously if exposed to air 暴露于空气自发着火
  • H224 Extremely flammable liquid and vapour 极端易燃液体和蒸气
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Packing GroupI
UN Number
Storage condition Store at room temperature, keep dry and cool {LY} Store at room temperature, keep dry and cool {} {LY} Store at room temperature, keep dry and cool {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store
Hazard Codes 4.2
Hazard Class4.2/4.3
Warnings 危化品目录(2015)
Restrict 危险品

其他信息

  • ⑴. 密封保存在低温、干燥并且有惰性气体保护的容器中。 ⑵. 避免与氧化物、酸、水分接触。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Bases - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organolithium 有机锂
  4. Alkyl Organolithium 烷基锂
  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organolithium 有机锂
  4. Alkyl Organolithium 烷基锂
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Metal Compounds 金属化合物

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