2,2-Dimethoxypropane 2,2-二甲氧基丙烷

CAS 77-76-9 MFCD00008479

化学结构图

77-76-9
SMILES: COC(C)(C)OC

化学属性

Mol. FormulaC5H12O2
Mol. Weight104.15
Refractive index1.3760 to 1.3800
Boiling Point83
Density0.847
Flash Point-9°C(lit.)
TSCAYes
Melting Point-47°C
Vapor Density3.59 (vs air)
Vapor Pressure60 mmHg ( 15.8 °C)
Solubility18 G/100 ML (25 ºC)
Stability对湿度敏感
Danger-Level甲类

别名和识别编码

Chemical Name2,2-Dimethoxypropane
Synonym 2 2-DIMETHOXYPROPANE REAGENT GRADE 98% 2,2-Dimethoxypropane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number77-76-9
PubChem Substance ID6495
EC Number201-056-0
Beilstein Registry Number635678
MDL NumberMFCD00008479
Reaxys-RN635678
Chemical Name Translation2,2-二甲氧基丙烷
LabNetwork Molecule IDLN00194059
InChIInChI=1S/C5H12O2/c1-5(2,6-3)7-4/h1-4H3
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分类

  • {uni_hamburg} no charge; acetal; 1fragment
  • {SA} Alpha Sort, Alphabetic, Analytical Standards, Analytical/Chromatography, Chemical Class, Chemical Synthesis, Chromatography, D, DID - DIN,
  • {SNA} Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chemical Class, Chemical Synthesis, Chromatography, D, DID - DIN, Environmental Standards, Others, Protecting and Derivatizing Reagents, Protection and Derivatization, Solvents, Synthetic Reagents, Volatiles/ Semivolatiles
  • {SNA} Chemical Synthes

产品应用

  • 可以用作羟基保护及脱水剂、缩合剂、环化剂等，在医药、农药、香料等的合成中有广泛的用途。

相关文献及参考

  • Short: II/25D
  • Methoxylating agent for preparation of acetals by acid-catalyzed exchange: J. Org. Chem., 25, 521 (1960). Also used as a water-scavenger in the preparation of acetals from higher-boiling alcohols and ketones: Org. Synth. Coll., 5, 292 (1973).
  • Widely used for the isopropylidenation of diols; see, e.g.: Org. Synth. Coll., 9, 450, 717 (1998). Isopropylidenation of acid-sensitive carbohydrates in the presence of 2,3-Dichloro-5,6-dicyanobenzoquinone, A11879: Acta Chem. Scand., 47, 843 (1993); preparation of acyclic mixed acetals of carbohydrates: Acta Chem. Scand., 48, 80 (1994). For use in the cyclization of N-Boc serine methyl ester to the oxazolidine, see: Org. Synth. Coll., 9, 300 (1998).
  • Beilstein:1,648
  • Methyl ester hydrochlorides of amino acids can be conveniently prepared with excess reagent in combination with conc. HCl. Water is removed in situ, thus displacing the equilibrium in favor of the ester: J. Org. Chem., 28, 3898 (1963). Methyl esters of non-aromatic acids can also be prepared with the reagent in MeOH with a catalytic amount of HCl or TMS chloride: Tetrahedron Lett., 38, 2685 (1997).

安全信息

GHS Symbol
WGK Germany2
Hazard Codes 3 F;Xi
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R36 Irritating to eyes 刺激眼睛
UN Number 1993 UN3271
Packing GroupII
Hazard Class3
Storage condition +4°C 4 4℃ Flammables area
Warnings 危化品目录(2015)
Restrict 危险品

其他信息

  • 蒸气密度:3.59 (vs air)
  • Sigma Aldrich:77-76-9(sigmaaldrich)
  • 蒸气压:60 mm Hg ( 15.8 °C)
  • Alfa Aesar:2,2-二甲氧基丙烷,98% 2,2-Dimethoxypropane, 98%(77-76-9)
  • 用途二:用作保护剂、缩合剂、环化剂、脱水剂等，在医药、农药、香料等的合成中有广泛的用途。
  • 存储注意事项:湿度敏感
  • 2,2-二甲氧基丙烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80177080 2.2-二甲氧基丙烷 500ml 220元 2011/04/16 A0057 2,2-二甲氧基丙烷 2,2-Dimethoxypropane 25ML 180元 2011/04/16 A0057 2,2-二甲氧基丙烷 2,2-Dimethoxypropane 500ML 480元
  • MSDS 信息:2,2-二甲氧基丙烷(77-76-9).msds
  • 用途一:用作医药中间体，主要用于羟基保护及脱水
  • MOL 文件:77-76-9.mol
  • Acros Organics:2，2-二甲氧基丙烷 2,2-Dimethoxypropane, 98%(77-76-9)
  • 海关编码:29110000
  • 外观性质:无色液体。
  • 有芳香气味。水中溶解度:18 g/100g (25°C)，溶于丙酮、苯、CCl4、醚、正庚烷和甲醇。
  • F:10-21
  • TCI Shanghai:2,2-二甲氧基丙烷 2,2-Dimethoxypropane,>;98.0%(GC)(77-76-9)
  • 检测方法:GC,NMR
  • 图谱信息:2,2-二甲氧基丙烷(77-76-9)红外图谱(IR2) 2,2-二甲氧基丙烷(77-76-9)红外图谱(IR1) 2,2-二甲氧基丙烷(77-76-9)核磁图( 13 CNMR) 2,2-二甲氧基丙烷(77-76-9)核磁图( 1 HNMR) 2,2-二甲氧基丙烷(77-76-9)质谱(MS)
  • 用途三:可以用作羟基保护及脱水剂、缩合剂、环化剂等，在医药、农药、香料等的合成中有广泛的用途。
  • 下游产品:去氧氟尿苷 --> 丁酰胺酸

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Alcohols - Oxygen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. D - Alphabetic
  5. DID - DIN - D
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  4. Protecting and Derivatizing Reagents - Protection and Derivatization
  5. Others - Protecting and Derivatizing Reagents
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Alkylation Reagents - Derivatization Reagents
  5. General Alkylation Reagents - Alkylation Reagents