Bis(2-oxo-3-oxazolidinyl)phosphinic chloride 二(2-氧代-3-唑烷基)次膦酰氯
CAS 68641-49-6 MFCD00010077
化学结构图
SMILES: O=P(Cl)(N1CCOC1=O)N1CCOC1=O
化学属性
| Mol. Formula | C6H8ClN2O5P |
|---|---|
| Mol. Weight | 255 |
| Melting Point | 191 |
| TSCA | No |
| Density | 1.71 |
| Stability | 易吸潮 |
别名和识别编码
| Chemical Name | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride |
|---|---|
| MDL Number | MFCD00010077 |
| Synonym | BOP-Cl Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic Chloride 双(2-氧代-3-噁唑烷基)次磷酰氯 双（2-氧代-3-恶唑烷基）次磷酰氯 |
| CAS Number | 68641-49-6 |
| Beilstein Registry Number | 87564149 |
| PubChem Substance ID | 87564149 |
| EC Number | 250-023-7 |
| Reaxys-RN | 3654596 |
| Chemical Name Translation | 二(2-氧代-3-唑烷基)次膦酰氯 |
| InChIKey | KLDLRDSRCMJKGM-UHFFFAOYSA-N |
| LabNetwork Molecule ID | LN00009083 |
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分类
- {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Oxazolines/Oxazolidines
产品应用
- 多肽缩合剂。适宜于因有空间位阻而不能与碳二亚胺类缩合剂反应的情形。
相关文献及参考
- For use in the direct selective 5'-acylation of nucleosides by carboxylic acids, (without 3'-protection), see: Tetrahedron, 44, 229 (1988). For high yield dehydration of carboxylic acids to anhydrides, see: Synthesis, 616 (1981). Also used in macrolide cyclization: J. Am. Chem. Soc., 104, 6818 (1982), and in formation of acyclic esters: Synth. Commun., 14, 515 (1984).
- Coupling reagent for which the rates of reaction with various nucleophiles are sufficiently different to permit a genuine "one-step" coupling of carboxylic acids with amines: Synthesis, 547 (1980). Particularly suitable for coupling N-alkyl amino acids: J. Org. Chem., 51, 3350 (1986). For discussion of strategies for one-step coupling in synthesis of amides, see: Synthesis, 413 (1984), and of the scope and limitations of the reagent in peptide coupling, see: Int. J. Pept. Prot. Res., 29, 574 (1987); J. Org. Chem., 55, 2895 (1990). See also Appendix 6.
- The mixed anhydride formed with carboxylic acids adds to imines to give ß-lactams: Synthesis, 63 (1982):
- These are also formed in high yield by cyclization of ß-amino acids: Bull. Korean Chem. Soc., 12, 457 (1991).
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R34 Causes burns 会导致灼伤
GHS Symbol
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331+P310
- P303+P361+P353
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 170,23,1986
其他信息
- 对潮湿敏感。
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