Sodium Dichloroacetate 二氯乙酸钠

CAS 2156-56-1 MFCD00070489

化学结构图

2156-56-1
SMILES: O=C([O-])C(Cl)Cl.[Na+]

化学属性

Mol. FormulaC2HCl2NaO2
Mol. Weight150.92
Melting Point198
TSCANo
Solubility可溶 IN COLD WATER
Appearance 微黄到白色结晶粉末,熔点189-192℃。

别名和识别编码

Chemical NameSodium Dichloroacetate
Synonym 2,2-二氯乙酸钠 Acetic acid, dichloro-, sodium salt DICHLOROACETIC ACID SODIUM SALT Dichloressigsäure Natriumsalz Dichloroacetate Sodium Dichloroacetate, sodium salt Dichloroacetic Acid Sodium Salt Dichloroacetic acid sodium salt Dichloroacetic acid, sodium salt NATRIUMDICHLORACETAT Natrium-dichloracetat SODIUM DICHLOROACETATE SODIUM DICHLOROACETIC ACID Sodium 2,2-dichloroacetate Sodium Dichloroacetate {Chemicalbook} Sodiumdichloroacetate,97% dichloro-aceticacisodiumsalt dichloroacetate,sodiumsalt dichloroctansodny dlchloroacetic acid sodium salt {} {Chemicalbook} Sodiumdichloracetate {} {} {hazard_com} Sodium dichloroacetate 二氯乙酸 钠盐
MDL NumberMFCD00070489
CAS Number2156-56-1
PubChem Substance ID517326
EC Number218-461-3
Reaxys-RN3916178
Chemical Name Translation二氯乙酸钠
Beilstein Registry Number3916178
Wiswesser Line NotationQVYGG &-NA-
LabNetwork Molecule IDLN00223290
InChIInChI=1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1
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分类

  • {SNA} Chemical Synthesis, Inhibitors of Aerobic Glycolysis (the Warburg Effect), Inorganic Salts, Pyruvate Dehydrogenase Kinase (PDK) Inhibitors, Sodium, Synthetic Reagents, 有氧糖酵解(Warburg效应), 癌症代谢, 癌症研究, 细胞生物学
  • {SNA} Cancer
  • {SNA} Che
  • {SNA} Cancer Metabolism, Cell Biology, Chemical Synthesis, Inhibitors of Aerobic Glycolysis (the Warburg Effect), Inorganic Salts, Pyruvate Dehydrogenase Kinase (PDK) Inhibitors, Sodium, Synthetic Reagents, 有氧糖酵解(Warburg效应), 癌症研究
  • {SNA} Aerobic Glycolysis (the Warburg Effect), Cancer Metabolism, Cancer Research, Cell Biology, Chemical Synthesis,
  • {SNA} Chemical Synthesis,

相关文献及参考

  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: IV/1a Title: Densities of Liquid Systems: Nonaqueous Systems and Ternary Aqueous Systems Author: Lacmann, R.; Synowietz, C. Editor: Schäfer, Kl. Source: Landolt-Börnstein, New Series Volume: IV/1a Year: 1974 ISBN: 3-540-06269-6 ISBN: 978-3-540-06269-1 Internet Resource: DOI:10.1007/b20003 RefComment: X, 716 pages. Hardcover Abstract: Volume IV/1 contains information on the densities of liquid systems. It may be considered as a supplement to volume II/1 of the 6th Edition, which contains only a few data on nonaqueous systems. Data are not listed for all systems but primarily for those of greater interest where data for a larger range of concentrations were available.

安全信息

WGK Germany2
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H351 Suspected of causing cancer 怀疑致癌
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSAG9275000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Storage condition +4°C Moisture Sensitive
Hazard Codes Xn Xi
UN Number 2811
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 164 gm/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   144,235,1997

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5281 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 23,78,1941

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 10,370,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4845 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 222,501,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   AJCNAC American Journal of Clinical Nutrition.  (American Soc. for Clinical
   Nutrition, Inc., 9650 Rockville Pike, Bethesda, MD 20814)  V.2-    1954-
   Volume(issue)/page/year: 33,1179,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 182 gm/kg
SEX/DURATION            : male 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   57,273,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4375 mg/kg
SEX/DURATION            : male 10 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   19,57,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2188 mg/kg
SEX/DURATION            : male 10 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   19,57,1992

其他信息

  • Sigma Aldrich:2156-56-1(sigmaaldrich)
  • Acros Organics:二氯乙酸钠 Sodium dichloroacetate, 98%(2156-56-1)
  • MSDS 信息:Dichloroacetic acid sodium salt(2156-56-1).msds
  • TCI Shanghai:二氯乙酸钠 Sodium Dichloroacetate,>;99.0%(T)(2156-56-1)
  • 二氯乙酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1719 二氯乙酸钠 Sodium Dichloroacetate 10G 416元 2014/06/02 D1048 二氯乙酸钠 Sodium Dichloroacetate 25G 740元 2014/06/02 D1719 二氯乙酸钠 Sodium Dichloroacetate 25G 702元
  • 图谱信息:二氯乙酸钠(2156-56-1)红外图谱(IR1) 二氯乙酸钠(2156-56-1)核磁图( 13 CNMR) 二氯乙酸钠(2156-56-1)红外图谱(IR2) 二氯乙酸钠(2156-56-1)核磁图( 1 HNMR) 二氯乙酸钠(2156-56-1)红外图谱(IR3)
  • MOL 文件:2156-56-1.mol
  • 敏感性:Moisture Sensitive
  • Alfa Aesar:二氯乙酸钠,97% Sodium dichloroacetate, 97%(2156-56-1)

系列性分类


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