• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} C-C Bond Formation, Chemical Synthesis, Fluorination Reagents, Organometallic Reagents, Organosilicon, Other Organosilicon, Other Synthetic Reagents for C-C Bond Formation, Synthetic Reagents, Trifluoromethylation
• {SNA} C-C Bond Formation, Chemical Synthesis, Fluorination Reagents, Other Synthetic Reagents for C-C Bond Formation, Synthetic Reagents, Trifluoromethylation
• {SNA} Chemical Synthesis, Organometallic Reagents, Organosilicon, Others
• {uni_hamburg} no charge; 1fragment
• {SNA} Chemical Synthesi
• {SNA} C-C Bond Formation, Chemical Synthesis, Fluorination Reagents, Organometallic Reagents, Organosilicon, Others,

产品应用

• 三氟甲基化试剂，醛和酮上添加三氟甲基基团。

相关文献及参考

• Alternatively, rapid and efficient trifluoromethylation of carbonyl compounds can be carried out at room temperature in DMSO, in the presence of molecular sieves, without fluoride or other basic catayst: Synlett, 112 (2006). The use of Tri-tert-butyl­phosphine, 10178 as a catalyst has also been advocated: Synlett, 267 (2006).
• For reviews of this and similar reagents, see: Chem. Rev., 97, 757 (1997); J. Fluorine Chem., 112, 123 (2001).
• In the presence of CsF and TMS-imidazole, aldimines are converted to ɑ-trifluoromethyl amines: Tetrahedron Lett., 40, 5475 (1999).
• In the presence of F-, aldehydes and ketones give, after hydrolysis of the intermediate silyl ethers, the trifluoromethyl carbinols: J. Am. Chem. Soc., 111, 393 (1989); J. Org. Chem., 56, 984 (1991); Org. Synth. Coll., 9, 711 (1998):
• Merck: 14,9683
• Short: III/35B
• Short: III/35F
• Similarly, alkyl or aryl thiocyanates are converted to the corresponding trifluoromethyl sulfides in generally good yields: Tetrahedron Lett., 38, 65 (1997). Selenocyanates behave similarly. Trifluoromethylation of aromatics bearing electron-withdrawing groups can be effected in the presence of KF, by displacement of nitro-, cyano- or chloro-substituents: J. Chem. Soc., Perkin 1, 3081 (1998).
• Valuable reagent for trifluoromethylation of electrophilic substrates.
• With a catalytic amount of TBAF, excellent yields of trifluoromethyl ketones can be obtained from methyl esters: Angew. Chem. Int. Ed., 37, 820 (1998).

安全信息

其他信息

• 上游原料:盐酸 --> N,N-二甲基甲酰胺 --> 镁 --> 三甲基氯硅烷 --> 碘化亚铜 --> 苯磺酰氯 --> 三氟乙酸钠
• Sigma Aldrich:81290-20-2(sigmaaldrich)
• Hazard Note:Flammable
• Acros Organics:三氟甲基三甲基硅烷 (Trifluoromethyl)trimethylsilane, 96%(81290-20-2)
• 敏感性:Moisture Sensitive
• 蒸气压:10.98 psi ( 55 °C)
• Alfa Aesar:（三氟甲基）三甲基硅烷,98% (Trifluoromethyl)trimethylsilane, 98%(81290-20-2)
• MOL 文件:81290-20-2.mol
• 用途一:三氟甲基化试剂（Trifluoromethylating Reagent）
• F:10-21
• TSCA:No
• 下游产品:4-氨基-2-氯三氟甲苯 --> 2-氯-4-硝基三氟甲苯 --> 4-三氟甲基烟酸 --> 2-氯-6-三氟甲基烟酸 --> 5-三氟甲基吡啶-2-羧酸 --> 5-溴-2-三氟甲基吡啶
• TCI Shanghai:(三氟甲基)三甲硅烷[三氟甲基化试剂] (Trifluoromethyl)trimethylsilane [Trifluoromethylating Reagent],>;95.0%(GC)(81290-20-2)
• (三氟甲基)三甲基硅烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 T1570 (三氟甲基)三甲硅烷[三氟甲基化试剂] (Trifluoromethyl)trimethylsilane [Trifluoromethylating Reagent] 25G 3299元 2011/04/16 T1570 (三氟甲基)三甲硅烷[三氟甲基化试剂] (Trifluoromethyl)trimethylsilane [Trifluoromethylating Reagent] 5G 930元 2010/06/21 279720250 (三氟甲基)三甲基硅烷 (Trifluoromethyl)trimethylsilane 96% 25 ML 5126元