Acetanilide 乙酰苯胺

CAS 103-84-4 MFCD00008674

化学结构图

103-84-4
SMILES: CC(=O)Nc1ccccc1

化学属性

Mol. FormulaC8H9NO
Mol. Weight135.16
Boiling Point254.9±23.0 °C at 760 mmHg
Melting Point113-115 °C
Density1.22
Flash Point145.6±11.9 °C
TSCAYes
Autoignition Point1004 °F
Vapor Density4.65 (vs air)
Vapor Pressure1 mmHg ( 114 °C)
Solubility溶于热水，易溶于乙醇、乙醚等。
Stability对光敏感

别名和识别编码

Chemical NameAcetanilide
CAS Number103-84-4
Synonym Acetanilide {LY} Acetanilide Acetoanilide Acetylaminobenzene Acetylanilide Acetylaniline Aceylaminobenzene Antifebrin Benzenamine, N-acetyl- Essigsäureanilid N-AcetylanilineN-Phenylacetamide N-phenylacetamide N-phenylethanamide N-乙醯苯胺 N-苯乙酰胺 N-苯乙醯胺 N-苯基乙酰胺 N-苯基乙酸胺,乙酰氨基苯,N-乙酰苯胺 NSC 203231 NSC 7636 Phenalgene Usaf ek-3 acetanilide acetonide acety {} {LY} Acetanilide {} {} {LY} Acetanilide {} {} {} {LY} Acetanilide {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {} {} {LY} Acetanilide {} {} {} {} {} {} {} {
EC Number203-150-7
Beilstein Registry Number606468
MDL NumberMFCD00008674
PubChem Substance ID904
Merck Number14,50
Chemical Name Translation乙酰苯胺
Wiswesser Line Notation1VMR
LabNetwork Molecule IDLN00199671
InChIInChI=1S/C8H9NO/c1-7(10)9-8-5-3-2-4-6-8/h2-6H,1H3,(H,9,10)
Canonical SMILESO=C(C)NC1=CC=CC=C1
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分类

  • {SNA} A-B, Puriss p.a., Analytical Reagents, Analytical Reagents for General Use, Analytical/Chromatography, Building Blocks,
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards A - B
  • {SNA} Analytical Standards,
  • {SNA} Building Blocks,

产品应用

  • 检验铈、铬、铁、亚铁氰化物、铅、锰、氯化剂、硝酸盐。过氧化氢溶液的稳定剂，有机微量分析，测定氮的标准。乙酰苯胺也是磺胺类药物的原料。

相关文献及参考

  • Merck:14,50 Beilstein: 12,IV,373
  • Short: II/27B
  • Merck:14,50
  • Chang, C., et al.: J. Nat. Prod., 73, 229 (2010),
  • Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),
  • Short: II/2

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSAD7350000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P301+P312+P330
Signal word Warning
Hazard Codes Xn
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Warnings 危化品目录(2015) 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 56 mg/kg/H-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Gastrointestinal - decreased motility or constipation
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   122,770,1901

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 14 mg/kg/D
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,62,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 48,204,1959

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 59 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M.,
   Springfiel

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 80,761,1991

Restrict 危险品

其他信息

  • 方法一:由苯胺经乙酸乙酰化而得。将苯胺和冰醋酸（过量100%）置于带夹套的搪玻璃反应器内，回流6-14h直至无游离苯胺为止。若用稀乙酸，则反应温度为150-
  • 外观性质:无色有闪光的小叶状固体。
  • 蒸气压:1 mm Hg ( 114 °C)
  • 标准值 不确定度 单位
  • 毒性分级:中毒
  • Sigma Aldrich:103-84-4(sigmaaldrich)
  • N-乙酰苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 81000217 乙酰苯胺;N-乙酰苯胺;退热冰 250g 32.9元 2011/08/23 81000380 乙酰苯胺;N-乙酰苯胺;退热冰 25g 21.4元 2011/08/23 81000227 乙酰苯胺;N-乙酰苯胺;退热冰 250g 31元
  • 略有苯胺及乙酸气味。在水中再结晶析出呈正交晶片状。无气味，溶解度: 1g、185ml冷水，1G/20ML 沸水， 1G/3,4ML 乙醇 - 1G/4ML 丙酮 1G/3,7ML 氯仿 - 1G/5ML 甘油 1G/8ML 二噁烷 - 1G/18ML 醚 - 1G/47ML苯，微溶于石油醚。 微溶于冷水，水合氯醛能增加其中在水中溶解度。碱性很弱。遇酸或碱性水溶液易分解成苯胺及乙酸。可燃，无臭。在空气中稳定，呈中性。约在95℃挥发。
  • 常规方法:采用内层塑料袋、外层麻袋或帆布袋包装，每袋净重50kg。贮存在阴凉、干燥、通风处，防火、防潮。用汽车或火车运输均可。按有毒化学品规定贮运。
  • 下游产品:磺胺 --> 4-氨基乙酰苯胺 --> 4-氨基苯乙酮 --> 磺胺喹恶啉 --> 磺草灵 --> 盐酸多西环素 --> 4-(4-氨基苯基)丁酸 --> 间氨基苯乙醚 --> 耐晒黄 G --> 柳氮磺吡啶 --> 2-[(4-氨基苯基)磺酰基]乙醇硫酸氢酯 --> 分散兰 301
  • 上游原料:乙酸 --> 氨基苯 --> 2-苯甲酰乙酰苯胺 --> 蒸馏罐
  • 图谱信息:N-乙酰苯胺(103-84-4)红外图谱(IR1) N-乙酰苯胺(103-84
  • 急性毒性:口服- 大鼠 LD50: 800 毫克/ 公斤; 口服- 小鼠 LD50: 1210 毫克/ 公斤
  • 方法一:由苯胺经乙酸乙酰化而得。将苯胺和冰醋酸（过量100%）置于带夹套的搪玻璃反应器内，回流6-14h直至无游离苯胺为止。若用稀乙酸，则反应温度为150-160℃，反应结束后趁热过滤，除去残渣，滤液冷却、结晶，离心过滤，水洗并干燥，即得产品。也可采用乙酐作酰化剂，反应在苯溶液中进行，乙酐过量150%。操作示例1将四只反应罐成梯形排列，最高一只反应罐装有分馏柱。苯胺从分馏柱顶部连续加入，回收乙酸与苯胺混合物从第二只反应罐连续加入，乙酸从第三只反应罐连续加入。控制不同的反应温度（第三只为160-170℃，第四只为200-210℃），使乙酸与苯胺进行气液相对流反应，反应生
  • MOL 文件:103-84-4.mol
  • 类别:可燃物品
  • 用途三:乙酰苯胺是磺胺类药物的原料，可用作止痛剂、退热剂和防腐剂。用来制造染料中间体对硝基乙酰苯胺、对硝基苯胺和对苯二胺。在第二次世界大战的时候大量用于制造对乙酰氨基苯磺酰氯（Acet
  • 检测方法:HPLC、GC,NMR,Rotation
  • 可燃性危
  • 方法一:由苯胺经乙酸乙酰化而得。将苯胺和冰醋酸（过量100%）置于带夹套的搪玻璃反应器内，回流6-14h直至无游离苯胺为止。若
  • Alfa Aesar:乙酰苯胺,98% Acetanilide, 98%(103-84-4)

系列性分类

  1. Research Essentials 基础科研
  2. Essential Chemicals - Research Essentials
  3. Inorganic Salts, Solutions and Reagents - Essential Chemicals
  4. Reagent Grade - Inorganic Salts, Solutions and Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Protected Amines - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Oximes - Nitrogen Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Analytical Reagents for General Use - Analytical Reagents
  4. Puriss p.a. - Analytical Reagents for General Use
  5. A-B, Puriss p.a. - Puriss p.a.
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Polyamines
  1. Analytical & Chromatography 分析化学与色谱
  2. Adsorbents, Filter Aids and Drying Agents
  3. Other Drying Agents