P-Anisidine 对甲氧基苯胺

CAS 104-94-9 MFCD00007864

化学结构图

104-94-9
SMILES: COc1ccc(N)cc1

化学属性

Mol. FormulaC7H9NO
Mol. Weight123
Density1.06
Autoignition Point959 °F
Boiling Point-
Melting Point54 - 56°C
Flash Point-
TSCAYes
Solubility微溶于水，溶于乙醇、乙醚、丙酮、苯等多数有机溶剂。
Appearance crystalline
Refractive index1.5559
Stability对光敏感
pH:A

别名和识别编码

Chemical Namep-Anisidine
MDL Number-
CAS Number104-94-9
EC Number203-254-2
Beilstein Registry Number471556
Synonym 4-Anisidine {PubChem} para-anisidine {} {PubChem} p-anisidine {} {} {PubChem} 4-methoxyaniline {} {} {} {PubChem} 4-anisidine monoacid conjugate {} {} {} {} {} {} {} {} {PubChem} 4-anisidine hydrochloride {} {} {} {} {} {PubChem} 4-anisidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} para-anisidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} p-anisidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} 4-methoxyaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID7732
Merck Number667
Reaxys-RN471556
Chemical Name Translation对甲氧基苯胺
Wiswesser Line NotationZR DO1
LabNetwork Molecule IDLN00195921
InChIInChI=1S/C7H9NO/c1-9-7-4-2-6(8)3-5-7/h2-5H,8H2,1H3
Canonical SMILESNC1=CC=C(OC)C=C1
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; ether; 1fragment
  • {SNA} Amines, Building Blocks, C7, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks

产品应用

  • An aromatic compound used in the detection of aldehydes or ketones in oils.

相关文献及参考

  • Short: II/27B
  • Merck:14,667
  • Short: II/5
  • Short: III/20a

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S1/2 None 上锁保管并避免儿童触及；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
  • R33 Danger of cumulative effects 有累积作用的危险
  • R45 May cause cancer 可能致癌
  • R50 Very toxic to aquatic organisms 对水生生物极毒
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P203
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P310+P330
  • P301+P312
  • P301+P316
  • P301+P317
  • P302+P317
  • P302+P350
  • P302+P352
  • P302+P352+P312+P361+P364
  • P304+P340
  • P304+P340+P311
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P307+P311
  • P308+P311
  • P308+P313
  • P308+P316
  • P309+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
  • P316
  • P318
  • P319
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P337+P317
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P361+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H300 Fatal if swallowed 吞食致命
  • H301 Toxic if swallowed 吞食有毒
  • H301+H311+H331
  • H310 Fatal in contact with skin 皮肤接触致命
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H330 Fatal if inhaled 吸入致命
  • H350 May cause cancer 可能致癌
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSBZ5450000
Packing GroupIII
UN Number 2431/2811 2811 UN 2811 6.1/PG 3 UN2431
Hazard Codes 6.1 T+,N T+,N,Xi
Hazard Class6.1
Storage condition RT, stored under argon {LY} RT, stored under argon {} {LY} RT, stored under argon {} {} {LY} RT, stored under argon {} {} {} {LY} RT, stored under argon {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {}
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
   Instituta.  (Leningrad, Russia) V.1-145, 1949-82.  Discontinued.
   Volume(issue)/page/year: 128,14,1979

TYPE OF TEST            : LD50 - Lethal

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene.  (Berlin, Ger.)
   V.1-18, 1930-61.  For publisher information, see IAEHDW.
   Volume(issue)/page/year: 15,447,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 806 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,900,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2900 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Blood - normocytic anemia
   Blood - other changes
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-

{h

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 196 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 202 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,155,

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 392 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse Bacteria - Escherichia coli
DOSE/DURATION           : 780 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 272,161,1992

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 160 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

Restrict 危险品

其他信息

  • 可燃性危险特性:明火可燃;
  • 毒性分级:中毒
  • 对甲氧基苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80080726 对甲氧基苯胺 100g 84.2元 2011/08/23 TA080202 对茴香胺 25g 187元 2011/04/16 A0487 对茴香胺 p-Anisidine 25G 175元
  • {Chemica
  • 方法一:（1）传统硫化钠法原料对硝基氯苯与甲醇、液碱进行甲氧基化反应，生成对硝基苯甲醚，用硫化钠还原对硝基苯甲醚，反应产物经分离、减压蒸馏后，得成
  • 方法一:（1）传统硫化钠法原料对硝基氯苯与甲醇、液碱进行甲氧基化反应，生成对硝基苯甲醚，用硫化钠还原对硝基苯甲醚，反应产物经分离、减压蒸馏后，得成品对氨基苯甲醚。在还原锅加入23%的硫化钠，搅拌加热至90℃，在4h内加入对硝基苯甲醚，加料温度控制在9
  • 方法一:（1）传统硫化钠法原料对硝基氯苯与甲醇、液碱进行甲氧
  • 检测方法:GC,NMR
  • TCI Shanghai:对氨基苯甲醚 p-Anisidine,>;98.0%(GC)(104-94-9)
  • 方法一:（1）传统硫化钠法原料对硝基氯苯与甲醇、
  • 上游原料:氢氧化钠 --> 甲醇 --> Α-球蛋白 --> 硫化钠 --> 4-硝基氯苯 --> 4-硝基苯甲醚
  • color:dark gray to brown
  • 防护措施:高毒。空气中最高容许浓度0.5mg/m3。防护方法参见“邻氨基苯甲醚”。
  • 用途一:用作染料和医药中间体
  • Acros Organics:4-甲氧基苯胺 p-Anisidine, 99%(104-94-9)
  • 用
  • 常规方法:用铁桶包装，每桶净重200kg。贮存于通风、干燥处，避免日晒。按有毒危险品规定贮运。
  • 图谱信息:对甲氧基苯胺(104-94-9)红外图谱(IR2) 对甲氧基苯胺(104-94-9)红外图谱(IR1) 对甲氧基苯胺(104-94-9)质谱(MS) 对甲氧基苯胺(104-94-9)红外图谱(IR3) 对甲氧基苯胺(104-94-9)核磁图( 13 CNMR) 对甲氧基苯胺(104-94-9)核磁图( 1 HNMR)
  • 灭火剂:雾状水、
  • 下游产品:杂氮双环磷酸酯 --> 4-氨基嘧啶 --> 分散兰 79 --> 2-氰基-6-甲氧基苯并噻唑 --> 6-甲氧基喹啉 --> 6-羟基喹啉 --> 2-氨基-6-甲氧基苯并噻唑 --> 冰染重氮组分 1 --> 叔丁基-4-羟基苯甲醚 --> 5-甲氧基苯并咪唑 --> 5-甲氧基-3-吲唑羧酸 --> 碱性兰54 --> 1-(4-甲氧基苯基)哌嗪盐酸盐 --> 6-甲氧基苯并噻唑-2-羧酸 --> 1-(4-甲氧基苯基)哌嗪 --> 5-甲氧基靛红 --> 6-甲氧基-2-甲基喹啉 --> 对甲氧基苯基硫脲 --> 间-油酰氨基-邻-甲氧基苯磺酸钠,净洗剂MA,洗净剂SL --> 4-氯苯甲酸1-(4-甲氧苯基)酰肼 --> 4'-甲氧基乙酰苯胺 --> 2-(4-甲氧苯基)肼基磺酸钠 --> 凡拉明蓝盐B --> 四氟硼酸-4-甲氧基重氮苯正酯 --> 颜料红 190 --> 吲哚美辛 --> 对甲氧基苯异氰酸酯 --> 阳离子黄X-6G --> 2-羟基-N-(4-甲氧基苯基)-11H-苯并[a]咔唑-3-甲酰胺 --> 6-甲氧基-4-甲基喹啉 --> 4-甲氧基氰苯 --> 6-甲氧基-2-甲基苯并噻唑 --> 4-氨基-2,5-二氯苯酚 --> 阳离子金黄X-GL --> 3-羟基-4'-甲氧基-2-萘甲酰苯胺 --> 活性红紫X-2R --> 显色盐蓝
  • {C
  • 海关编码:292222
  • Sigma Aldrich:104-94-9(sigmaaldrich)
  • 用途三:该品主要用于染料工业，制取冰染染料，是枣红色基GP、蓝色盐VB、色酚AS-RL、色酚AS-SG、C
  • 类别:有毒物品

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Ethers - Oxygen Compounds
  1. C8 - Amines
  1. C10 to C11 - Amines
  1. C12 - Amines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amines 胺
  6. C2 to C6
  1. Materials Science 材料科学
  2. Building Blocks for Liquid Crystals