Methyl thioglycolate 巯基乙酸甲酯

CAS 2365-48-2 MFCD00004873

化学结构图

2365-48-2
SMILES: COC(=O)CS

化学属性

Mol. FormulaC3H6O2S
Mol. Weight106.14 g/mol
Density1.2
Refractive index1.4640 to 1.4670
Flash Point51°C(lit.)
TSCAYes
Boiling Point42-43
Melting Point-3°
Appearance 巯基乙酸甲酯(2365-48-2)为无色透明。密度(20℃)1.170~1.180。
Solubility40 g/L (20 °C)
pH:A

别名和识别编码

Chemical NameMethyl thioglycolate
MDL NumberMFCD00004873
CAS Number2365-48-2
Synonym 2-巯基乙酸甲酯 Acetic acid, mercapto-, methyl ester METG METHYL MERCAPTOACETATE METHYL THIOGLYCOLLATE Mercaptoacetic Acid Methyl Ester, Methyl Mercapto Mercaptoacetic Acid Methyl Ester, Methyl Mercaptoacetate Mercaptoacetic acid methyl ester Methanethiol, methoxy- Methyl 2-mercaptoacetate Methyl Thioglycolate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number219-121-7
Beilstein Registry Number506259
PubChem Substance ID16907
Chemical Name Translation巯基乙酸甲酯
Reaxys-RN506259
Wiswesser Line NotationSH1VO1
LabNetwork Molecule IDLN00226955
InChIInChI=1S/C3H6O2S/c1-5-3(4)2-6/h6H,2H2,1H3
Canonical SMILESO=C(OC)CS
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分类

  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfur Compounds, Thiols/Mercaptans
  • {SNA} Building Blocks, Catalysis and Inorganic Chemistry, Chemical Synthesis, Organic Building Blocks, Photocatalysis, Sulfur Compounds, Thiols/Mercaptans
  • {Chemicalbook} 农药中间体: 除草剂中间体: 磺酰脲类除草剂

产品应用

  • 医药及农药中间体。

相关文献及参考

  • Beilstein:3(4)614

安全信息

RTECSAI7350000
Packing GroupIII
UN Number 1992 UN1228
Risk Statements
  • R10 Flammable 易燃
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Storage condition Air Sensitive
GHS Symbol
WGK Germany1
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H331 Toxic if inhaled 吸入中毒
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P310+P330
  • P301+P312
  • P301+P316
  • P301+P317
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P303+P361+P353
  • P304+P312
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P316
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P332+P317
  • P333+P313
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard Codes 3
Hazard Class3/6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 252 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete.  (VEB
   Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem.
   Rep.)  V.1-    1955-  Volume(issue)/page/year: 20,575,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Skin and Appendages - hair
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0570921

其他信息

  • Acros Organics:巯基乙酸甲酯 Methyl thioglycolate, 95%(2365-48-2)
  • 上游原料:巯基乙酸
  • Sigma Aldrich:2365-48-2(sigmaaldrich)
  • 图谱信息:巯基乙酸甲酯(2365-48-2)核磁图( 1 HNMR) 巯基乙酸甲酯(2365-48-2)核磁图( 13 CNMR) 巯基乙酸甲酯(2365-48-2)红外图谱(IR1) 巯基乙酸甲酯(2365-48-2)质谱(MS)
  • 敏感性:Air Sensitive
  • 海关编码:29309070
  • MSDS 信息:Methyl mercaptoacetate(2365-48-2).msds
  • 用途一:巯基乙酸甲酯是除草剂噻吩磺隆的原料。
  • 巯基乙酸甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1287 巯基乙酸甲酯 Methyl Thioglycolate 25G 150元 2014/06/02 T1287 巯基乙酸甲酯 Methyl Thioglycolate 500G 630元 2010/06/21 148880050 巯基乙酸甲酯 Methyl thioglycolate 95% 5 GR 248元
  • Alfa Aesar:巯基乙酸甲酯,98% Methyl mercaptoacetate, 98%(2365-48-2)
  • 用途二:医药及农药中间体。
  • MOL 文件:2365-48-2.mol
  • TCI Shanghai:巯基乙酸甲酯 Methyl Thioglycolate,>;98.0%(GC)(2365-48-2)
  • 下游产品:5-氨基苯并噻吩 --> 3-羧甲基绕丹宁 --> 3-氨基-2-噻吩甲酸甲酯 --> 5-氯-4-甲氧基噻吩-3-羰酰氯 --> 噻吩黄隆 --> 4-氯噻吩并[3,2-d]嘧啶 --> 3-羟基-2-噻吩甲酸甲酯 --> 4-甲氧基噻吩-3-羧酸 --> 3-氨基-5-叔丁基噻吩-2-甲酰胺 --> 3-氯噻吩-2-羧酸甲酯 --> 4-氨基噻吩-2,3-二甲酸二甲酯盐酸盐 --> 3-氨基-4-苯基噻吩-2-甲酸甲酯 --> 3-氨基噻吩-2-甲酰胺 --> 5-硝基-1-苯并噻吩-2-羧酸 --> 3-氨基-4-甲基噻吩-2-甲酸甲酯 --> 4-氧四氢噻酚-3-羧酸甲酯
  • 方法一:其制备方法是在反应釜内加入巯基乙酸和甲醇,搅拌,滴加少量浓硫酸为催化剂,滴完,回流反应12h,反应结束后,加入水洗涤至中性,分水,得成品。 HSCH 2 COOH+CH 3 OH[H 2 SO 4 ]→HSCH 2 COOCH 3 +H 2 O

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