Akt

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APcK110

[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol

R428

AT13148

(2S)-N1-[4-Methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide

BAY1082439

AZD8186

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

Insulin-likeGrowthFactor-1ReceptorInhibitor

CID 9825149

A-443654

TYRPHOSTIN AG 490

N-[[(3S)-3-AMINO-1-(5-ETHYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3-PYRROLIDINYL]METHYL]-2,4-DIFLUORO-BENZAMIDE

目录项下的产品

1001083-74-4 / MFCD101083744
APcK110 is a novel Kit inhibitor . APcK110 inhibits proliferation of the mastocytosis cell line HMC1.2 and the SCF-responsive cell line OCI/AML3 in a dose-dependent manner . APcK110 is a more potent inhibitor of OCI/AML3 proliferation than the clinically used Kit inhibitors imatinib and dasatinib and at least as potent as cytarabine. APcK110 inhibits the phosphorylation of Kit, Stat3, Stat5, and Akt in a dose-dependent fashion, showing activity of APcK110 on Kit and its downstream signaling pathways . APcK110 may have potent application in AML.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1009298-09-2 / MFCD109298092
Azd-8055
[5-[2,4-二((3S)-3-甲基吗啉-4-基)吡啶并[2,3-D]嘧啶-7-基]-2-甲氧基苯基]甲醇

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
√

1037624-75-1 / MFCD137624751
(S)-1-(6,7-Dihydro-5H-Benzo[6,7]Cyclohepta[1,2-C]Pyridazin-3-Yl)-N3-(7-(Pyrrolidin-1-Yl)-6,7,8,9-Tetrahydro-5H-Benzo[7]Annulen-2-Yl)-1H-1,2,4-Triazole-3,5-Diamine
(S)-1-(6,7-二氢-5H-苯并[6,7]环庚并[1,2-c]哒嗪-3-基)-N3-(7-(吡咯烷-1-基)-6,7,8,9-四氢-5H-苯并[7]环庚烯-2-基)-1H-1,2,4-三唑-3,5-二胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

1056901-62-2 / MFCD156901622
AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors. AT13148 is currently being developed by Astex Pharmaceuticals. AT131148 was identified utilizing high-throughput X-ray crystallography and fragment-based lead discovery techniques. AT13148 caused substantial blockade of AKT, p70S6K, PKA, ROCK and SGK substrate phosphorylation and induction of apoptosis in both a concentration and time-dependent manner in cancer cells with clinically relevant genetic defects both in vitro and in vivo.

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1217486-61-7 / MFCD317486617
Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Check for active clinical trials or closed clinical trials using this agent.
(2S)-N1-[4-甲基-5-[2-(2,2,2-三氟-1,1-二甲基乙基)-4-吡啶基]-2-噻唑基]-1,2-吡咯烷二甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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中华人民共和国
√

1375469-38-7 / MFCD475469387
BAY1082439 is an orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha and beta isoforms with potential antineoplastic activity. PI3K alpha/beta inhibitor BAY1082439 selectively inhibits both PI3K alpha, including mutated forms of PIK3CA, and PI3K beta in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K-expressing and/or PTEN-driven tumor cells. By specifically targeting class I PI3K alpha and beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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1627494-13-6 / MFCD727494136
(R)-8-(1-((3,5-Difluorophenyl)Amino)Ethyl)-N,N-Dimethyl-2-Morpholino-4-Oxo-4H-Chromene-6-Carboxamide
(R)-8-(1-((3,5-二氟苯基)氨基)乙基)-N,N-二甲基-2-吗啉-4-氧代-4H-苯并吡喃-6-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

36707-00-3 / MFCD36707003
4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

468740-43-4 / MFCD68740434
(S)-4-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one
(S)-4-((2-(3-氯苯基)-2-羟乙基)氨基)-3-(4-甲基-6-吗啉-1H-苯并[d]咪唑-2-基)吡啶-2(1H)-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

475488-23-4 / MFCD75488234
5-[3-(Phenylmethoxy)Phenyl]-7-[Trans-3-(1-Pyrrolidinylmethyl)Cyclobutyl]-7H-Pyrrolo[2,3-d]Pyrimidin-4-Amine
5-(3-苄氧基苯基)-7-[反式-3-[(吡咯烷-1-基)甲基]环丁基]-7H-吡咯并[2,3-D]嘧啶-4-胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

552325-16-3 / MFCD52325163
A-443654

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

133550-30-8 / MFCD00209833
(E)-N-Benzyl-2-Cyano-3-(3,4-Dihydroxyphenyl)Acrylamide
(E)-N-苄基-2-氰基-3-(3,4-二羟苯基)丙烯酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1004990-28-6 / MFCD11846250
(S)-N-[[3-Amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl]-2,4-difluorobenzamide

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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