1-Chloroethyl Chloroformate 1-氯乙基氯甲酸酯
CAS 50893-53-3 MFCD00000647
化学结构图
SMILES: CC(Cl)OC(=O)Cl
化学属性
| Mol. Formula | C3 |
|---|---|
| Mol. Weight | 143 |
| Refractive index | 1.4220 to 1.4250 |
| Boiling Point | 118-119 |
| Vapor Pressure | 3.25 psi ( 20 °C) |
| Density | 1.325 |
| Flash Point | 41°C(lit.) |
| TSCA | No |
| Melting Point | -65° |
别名和识别编码
| Chemical Name | 1-Chloroethyl Chloroformate |
|---|---|
| CAS Number | 50893-53-3 |
| Synonym | 1-Chloroethyl Carbonochloridate 1-Chlorethoxycarbonylchlorid 1-chloroethyl chloroformate α-chloroethyl chloroformate ACE-Cl 1-Chlorocarbonyloxy-1-chloroethane 1-氯乙基氯甲酸酯 氯甲酸-1-氯乙酯 1-Chlorethyl-chlorocarbonat 1-Chloroethyl Chloroformate ?-Chloroethoxycarbonyl Chloride Chlorameisensäure-1-chlorethylester Chloroformic acid 1-chloroethyl ester chlorocarbonic acid-(1-chloro-ethyl ester) Chloroformic Acid 1-Chloroethyl Ester Carbonochloridic acid, 1-chloroethyl ester |
| PubChem Substance ID | 521305 |
| EC Number | 256-834-2 |
| Beilstein Registry Number | 1747601 |
| MDL Number | MFCD00000647 |
| Reaxys-RN | 1747601 |
| Chemical Name Translation | 1-氯乙基氯甲酸酯 |
| InChIKey | QOPVNWQGBQYBBP-UHFFFAOYSA-N |
| LabNetwork Molecule ID | LN00224414 |
| InChI | InChI=1S/C3H4Cl2O2/c1-2(4)7-3(5)6/h2H,1H3 |
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分类
- {uni_hamburg} no charge; carbonyl chloride; racemate; 1fragment
- Miscellaneous Reagents
- {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
产品应用
- 有机合成。是一种高效温和的脱苄基保护基团试剂，尤其对含有易被还原官能团的化合物，采用该试剂不会影响分子中的其它官能团；还应用于脱去三级胺上的烷基, 所得氨基甲酸酯在甲醇中加热，即可脱去甲酸酯基得到高收率的仲胺；医药合成方面用于头孢泊肟酯，坎地沙坦酯，头孢替安酯，巴氨西林，安吡昔康等。
相关文献及参考
- Short: III/39
- Short: EINECS
- Reagent, introduced by Olofson, and found to be superior to other chloroformates for dealkylation of tert-amines, e.g. N-alkylpiperidines to piperidines: J. Org. Chem., 49, 2081, 2795, 2081 (1984). For selective debenzylation of tert-amines, see: Synlett, 195 (1993). For reviews, see: Pure Appl. Chem., 60, 1715 (1988); Synthesis, 1 (1989).
- Beilstein:3,12
安全信息
GHS Symbol
- H226 Flammable liquid and vapour 易燃液体和蒸气
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H331 Toxic if inhaled 吸入中毒
- H302 Harmful if swallowed 吞食有害
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331+P310
- P303+P361+P353
- P304+P340
- P304+P340+P310
- P305+P351+P338
- P305+P351+P338+P310
- P308+P313
- P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
- P370+P378
- P403+P233
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R10 Flammable 易燃
- R22 Harmful if swallowed 吞咽有害
- R23 Toxic by inhalation 吸入有毒
- R34 Causes burns 会导致灼伤
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
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