CAS 7681-49-4 MFCD00003524-Sodium Fluoride 氟化钠 -LabNovo

Sodium Fluoride 氟化钠

CAS 7681-49-4 MFCD00003524

化学结构图

SMILES: [F-].[Na+]

化学属性

Mol. Formula	NaF
Mol. Weight	42
Density	1.005 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.3252(lit.)
Melting Point	993
TSCA	Yes
Boiling Point	1700
Solubility	Soluble in water (1 M). Insoluble in ethanol.
Vapor Pressure	1.4 mmHg ( 0 °C)
Stability	对湿度敏感
Flash Point	1704°C
Appearance	powder

别名和识别编码

Chemical Name	Sodium Fluoride
MDL Number	MFCD00003524
PubChem Substance ID	5235
CAS Number	7681-49-4
EC Number	231-667-8
Merck Number	14,8618
Synonym	Dentalfluoro Florinse Trisodium trifluoride { 氟化钠, 99.99% (METALS BASIS) Na frinse Lemof Sodium monofluoride Fluorocid credo Floridine {Chemica T-Fluoride Lea-Cov Sodium fluoride cyclic dimer Credoduraphat Fluorid sodny BETZ 0673 Phos-Flur {Ch FLUORIDE STANDARD Cavi-trol 氟化鈉 Alcoa sodi Flura drops Studafluor Pergantene disodiumdifluoride Flurcare Fluorinse {C F1-Tabs 氟化钠 Karidium Ir Flura Karigel 氟离子标准溶液 MERCARE SODIUM FLUORIDE Natrium fluoride
Chemical Name Translation	氟化钠
InChIKey	PUZPDOWCWNUUKD-UHFFFAOYSA-M
Wiswesser Line Notation	NA F
LabNetwork Molecule ID	LN00193004
InChI	InChI=1S/FH.Na/h1H;/q;+1/p-1

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产品应用

作木材防腐剂,医药防腐剂，焊接助熔剂及造纸工业、本公司生产的产品是牙膏特定级;也可作饮用水的净水剂；制革工业的生皮和表皮处理；轻金属冶炼精练和保护层；胶合剂防腐；和沸腾钢的制造。

安全信息

Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, Gloves Eyeshields, Faceshields, Gloves Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

WGK Germany1

RTECSWB0350000

UN Number 1690

Risk Statements

R25 Toxic if swallowed 吞咽有毒
R32 Contact with acids liberates very toxic gas 与酸接触释放出毒性很高的气体
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Storage condition 密封保存。贮存期间严禁与水接触，不要贮存在酸附近 Hygroscopic 2-8°C

GHS Symbol

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H301 Toxic if swallowed 吞食有毒

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P310+P330
P302+P350
P305+P351+P338
P337+P313

Signal word Danger

Packing GroupIII

Hazard Codes 6.1 T Xn

Hazard Class6.1

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2190 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,237,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4368 mg/kg/30W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,237,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4242 mg/kg/30W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 27,237,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14 mg/kg/43W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   100,97,1933

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 7 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Behavioral - fluid intake
   Behavioral - muscle weakness
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   81,811,1923

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1662 mg/kg
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   222,816,1972

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
REFERENCE :
   CARYAB Caryologia.  (Via G. LaPira 4, 50121 Florence, Italy)  V.1-    1948-
   Volume(issue)/pa

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   CYGEDX Cytology and Genetics (English Translation).  Translation of TGANAK.
   (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011)  V.8-    1974-
   Volume(issue)/page/year: 16(6),41,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 300 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 187,165,1987

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 86 mg/L
REFERENCE :
   WATRAG Water Research.  (Pergamon Press Ltd., Headington Hill Hall, Oxford
   OX3 0BW, UK) V.1-    1967-  Volume(issue)/page/year: 14,1613,1980

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Multiple routes
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 60 ug/L
REFERENCE :
   GNAMAP Gigiena Naselennykh Mest.  Hygiene in Populated Places. (Izdatel'stvo
   Zdorov'ya, Kiev, USSR) V.7-    1967- Volume(issue)/page/year: 15,36,1976

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 139,193,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Fertility - male fertility index

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 9 mg/kg
SEX/DURATION            : female 10-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Repr

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 620 mg/kg
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JONUAI Journal of Nutrition.  (Subscription Dept., 9650 Rockville Pike,
   Bethesda, MD 20014) V.1-    1928-  Volume(issue)/page/year: 103,1319,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intratesticular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 ug/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   REPTED Reproductive Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1987-  Volume(issue)/page/year:
   5,505,1991

其他信息

用途二:在微量分析中测定钪、光电比色中测定磷及钢铁分析试剂、掩蔽剂、防腐剂
F:
MOL 文件:7681-49-4.mol
Hazard Note:Toxic/Hygroscopic
溶于水，有毒，水溶液腐蚀玻璃。对湿敏感。水中溶解度(g/100ml)：15℃时4,25℃时4.3，100℃时5，不溶于乙醇。水溶液部分水解呈碱性反应。新配制的饱和溶液pH为7.4。其水溶液能使玻璃发毛，但其干燥的结晶或粉末可存放在玻璃瓶内。中等毒，半数致死量(大鼠，经口)0.18g/kg。有强刺激性。
MSDS 信息:氟化钠(7681-49-4).msds
所属类别二:无机化工产品: 无机盐: Ch氟化合物
方法一:中和法在反应器中加入纯碱(用母液溶解)，然后将配成的30％氢氟酸溶液用泵打入反应器中，至Ph值达8～9时即停止加酸，搅拌使其反应，至Ph＞8～9时，再加酸至Ph 8～9，如无二氧化碳气泡逸出即为终点。反应料液静置1h后，经离心分离、干燥、粉碎，制得氟化钠成品。其 2HF+Na2CO3→2NaF+H2+CO2↑ 熔浸法将萤石、纯碱和石英砂在800～900℃下煅烧，然后用水浸取，过滤，把滤液再经蒸发、结晶、干燥后，制得氟化钠成品。其 CaF2+Na2CO3+SiO2→2NaF+CaSiO3+CO2↑ 氟硅酸钠法将磷肥厂废气制得的氟硅酸钠和碳酸钠按1：2的摩尔比混合，在约80℃反
F:10
参考质量标准:国家标准GB 4293—84 指标名称指标一级二级三级氟化钠(NaF)/%≥ 98 95 84 氧化硅(SiO2)/%≤
注意事项:严禁与其它农药或物质混
{Chemicalb
氟化钠价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 10019618 氟化钠 500g 24元 2011/08/23 10019628 氟化钠 500g 22元 2011/08/23 10019608 氟化钠 500g 35元
职业标准:TLV-TWA 2.5 毫克(氟)/ 立方米; STEL 5 毫克(氟)/ 立方米
水中溶解度(g/100ml):不同温度(℃)时每100毫升水中的溶解克数: 3.66g/0℃;4.06g/20℃;4.22g/30℃;4.4g/40℃ 4.68g/60℃;4.89g/80℃;5
防护措施:本品有毒，LD50=180mg/kg。能腐蚀皮肤、刺激粘膜，长期接触有损神经系统。操作人员须穿戴工作服、口罩和手套，严防中毒。
Acros Organics:氟化钠 Sodium fluoride, for analysis, 99+%(7681-49-4)
图谱信息:氟化钠(7681-49-4
{C
敏感性:Hygroscopic
方法二:熔浸法将萤石、纯碱和石英砂，在高温(800～900℃)下煅烧，然后用
用途四:作食品强化剂。我国规定可用于食盐，最大使用量为0.1g/kg。
可燃性危险特性:不燃; 遇酸放出有毒氟化氢气体; 受热产生有毒氟化物和氧化钠烟雾
下游产品:氟硅酸钠 --> 3-氨基-2-氟吡啶
在牙膏中的应用:将氟化钠加到牙膏中能起到防龋作用，因为氟化物与牙釉质作用可在牙釉质表面形成氟磷灰石，提高牙釉质的硬度和抗酸能力，并可减少菌斑的形成,减少龋齿的发病率。含氟牙膏的确有一定的防龋效果。早在19世纪中叶，欧洲已让孕妇口服氟化钙以防龋;到了20世纪，氟化物被全世界公认为有效的防龋剂。一般的含氟牙膏中，氟化钠的含量是0.22-0.33%，单氟磷酸钠的含量是0.76%，如此微小的含量，已足以对人的牙齿产生良好的保护作用，可降低龋患病率28%。按照牙膏中所含氟化物的不同，含氟牙膏分为以下几种：氟化钠牙膏、单氟磷酸钠牙膏、氟化亚锡牙膏、氟化胺牙膏等。目前我国市场上最常见的含氟牙膏是氟化钠牙膏和单氟磷酸钠牙膏，或者同时含有氟化钠和单氟磷酸钠
类别:农药