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• {SNA} All Alphabetically Sorted, Alphabetical Index of Analytical Standards, Amino Acids, Peptides & Proteins, Analytical Standards, Analytical/Chromatography, Biogenic Amines, Chromatography, Flavors and Fragrances, Food & Beverage Standards, Life Sciences Standards, M-R, P, PU - PZ, Polyamine, Substance Classification, other
• {SNA} Bioactive Small Molecules, Building Blocks, Chemical Synthesis, D-DIF, Hordeum vulgare (Barley), Nitrogen Compounds, Nutrition Research, Organic Building Blocks, Phytochemicals by Plant (Food/Spice/Herb),
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产品应用

• A GABA precursor in many biological systems.

相关文献及参考

• [2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.
• 2. J. Chem. Soc. Perkin Trans. I , 3179, (1992)
• Merck:14,7947
• Merck:14,7947 Beilstein:4,264
• Short: EINECS
• Short: III/31a
• [1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47.
• [1]. Hauschild MZ. Putrescine (1,4-diaminobutane) as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). Ecotoxicol Environ Saf. 1993 Oct;26(2):228-47.
• [2]. Sequerra EB, et al. Putrescine as an important source of GABA in the postnatal rat subventricular zone. Neuroscience. 2007 May 11;146(2):489-93.

安全信息

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 463 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Sense Organs and Special Senses (Eye) - ptosis
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0538638

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1750 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 18(6),9,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1576 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Kidney, Ureter, Bladder - other changes in urine composition
   Skin and Appendages - dermatitis, othe

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 83,481,192

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - mouse Liver
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Ascites tumor
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   AMOKAG Acta Medicia Okayama.  (Okayama Univ. Medical School, Okayama, Japan)
    V.27    1973-  Volume(issue)/page/year: 33,149,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 314 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 28,237,1983

其他信息

• Alfa Aesar:1,4-二氨基丁烷,98+% 1,4-Diaminobutane, 98+%(110-60-1)
• 外观性质:无色结晶，有六氢吡啶的气味。
• 毒性分级:中毒
• Acros
• 急性毒性:口服-小鼠 LDL0: 1600 毫克/公斤
• 存储注意事项:氮气保护;空气敏感
• 检测方法:GC,NMR
• 类别:有毒物品
• MSDS 信息:1,4-丁二胺(110-60-1).msds
• 储运特性:库房通风低温干燥; 与氧化剂、酸类、食品化工添加剂分开存放
• 下游产品:2,3,5,6-四甲基吡嗪 --> N-叔丁氧羰基-1,4-丁二胺 --> 亚精胺 --> 菌核净
• 灭火剂:干粉、泡沫、二氧化碳、砂土
• 图谱信息:四亚甲基二胺 (110-60-1)质谱(MS) 四亚甲基二胺 (110-60-1)红外图谱(IR2) 四亚甲基二胺 (110-60-1)红外图谱(IR3) 四亚甲基二胺 (110-60-1)红外图谱(IR1)
• F:3-10-23-34
• Sigma Aldrich:110-60-1(sigmaaldrich)
• TCI Shanghai:1,4-丁二胺 1,4-Diaminobutane,>;98.0%(GC)(110-60-1)
• 1,4-Diaminobutane is a GABA precursor in many biological systems and synthon for amido-ureas.
• 用途一:有机合成中间体，用于制药和生化研究。
• 方法一:由吡咯与盐酸羟胺反应得丁二肟，再经还原而得丁二胺。
• 易溶于水，能吸收二氧化碳。有强烈氨臭。其盐酸盐[333-93-7]为白色结晶，熔点290℃，能溶于水，不溶于甲醇。
• 上游原料:氢氧化钠 --> 盐酸 --> N,N-二甲基甲酰胺 --> 碳酸钠 --> 氧化钙 --> 邻苯二甲酰亚胺 --> 二甲基乙二醛肟 --> 1,4-二氯丁烷
• MOL 文件:110-60-1.mol
• 可燃性危险特性:明火可燃;高热分解有毒氮氧化物烟雾
• 敏感性:Air Sensitive & Hygroscopic